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A kind of compound and preparation method thereof

A compound and product technology, applied in the field of medicine, can solve the problem of few types, achieve good anti-inflammatory activity and anti-oxidation, inhibit lipid peroxidation, and the effect of simple and easy preparation method

Active Publication Date: 2021-10-19
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that there are few types of drugs with anti-inflammatory and antioxidant effects extracted from plants in the prior art, the embodiment of the present invention provides a compound and its preparation method and application

Method used

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  • A kind of compound and preparation method thereof
  • A kind of compound and preparation method thereof
  • A kind of compound and preparation method thereof

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Embodiment Construction

[0027] In order to make the purpose, technical solution and advantages of the present invention clearer, the implementation manners of the present invention will be further described in detail below.

[0028] The embodiment of the present invention provides a kind of compound, and the structure of this compound is:

[0029] The name of the compound is (7'R,8S,8'R)-4'-hydroxy-3,3'-dimethoxy-9'-oxo-8-8',9'-O-9- Lignans, wherein, R is R configuration, S is S configuration.

[0030] On the other hand, the embodiment of the present invention also provides a preparation method of the above compound, the preparation method comprising:

[0031] 6 kg of large star anise branches and leaves were soaked overnight with ethanol and then extracted to obtain an extract;

[0032] Concentrate the extract to obtain 650 g of extract;

[0033] Disperse the extract with 2.0L of distilled water, extract with equal volumes of ethyl acetate, recover the ethyl acetate, and obtain the crude produc...

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Abstract

The invention discloses a compound, its preparation method and application, and belongs to the field of medicine. The name of the compound is (7'R,8S,8'R)-4'-hydroxy-3,3'-dimethoxy-9'-oxo-8-8',9'-O-9- Lignans, wherein, R is R configuration, S is S configuration. The preparation method comprises: soaking the branches and leaves of star anise with ethanol and then extracting to obtain an extract; concentrating the extract to obtain an extract; performing extraction, recovering the ethyl acetate to obtain a crude product; refining the crude product to obtain the compound. The compound can better inhibit the release of PAF-stimulated polymorphonuclear leukocyte glucuronidase, and at the same time has the ability to significantly inhibit Fe 2+ Cysteine-induced liver microsome lipid peroxidation activity shows that this compound has good anti-inflammatory activity and anti-oxidation effect, and can be used as an anti-inflammatory and anti-oxidation drug.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound and a preparation method thereof. Background technique [0002] Searching for drugs with potential clinical application value from traditional Chinese medicine and natural medicine is gradually attracting the attention of researchers. Studies have found that drugs extracted from plants have broad prospects because of their small toxic and side effects. Since there are few types of drugs extracted from plants that have both anti-inflammatory and antioxidant effects, it is urgent to find drugs that have both anti-inflammatory and antioxidant effects extracted from plants to enrich their types. Contents of the invention [0003] In order to solve the problem that there are few types of drugs with anti-inflammatory and anti-oxidative effects extracted from plants in the prior art, the embodiment of the present invention provides a compound and its preparation method and applicat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/00C07H15/26A61P29/00A61P39/06
CPCA61P29/00A61P39/06C07H1/00C07H15/26
Inventor 方振峰文若剑曹晓琴施璐
Owner JIANGHAN UNIVERSITY