Thamnolia vermicularis/Lethariella cladonioides extract, preparation method and applications thereof

A technology of extract and snow tea, applied in the field of snow tea extract and its application, to achieve the effects of promoting proliferation, environmental friendliness, and simple extraction method

Active Publication Date: 2018-10-16
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report of using glacier wa

Method used

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  • Thamnolia vermicularis/Lethariella cladonioides extract, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take Baixue tea leaves (water content less than 5%) and pass through an 80-mesh sieve after crushing. Take 10 g of the powder and add it to 200 mL of glacier water. Ultrasonic (500 W) for 30 minutes; centrifuge and collect the filtrate.

[0024] Then add 200mL glacier water and repeat the extraction once. After the filtrates are combined, freeze-dry at -10--15°C, collect the solids, and obtain the snow tea extract.

[0025] The glacier water is taken from Dorje Qudeng Nima Spring in the Himalayas (5128 meters above sea level). The deuterium content in the glacier water is 134ppm, pH=7.4, does not contain bromate, and contains the following components: Sr 2+ 0.2~0.5mg / L, K + 0.5~10.0mg / L, Na + 1.0~5.0mg / L, Ca 2+ 14.0~30.0mg / L and Mg 2+ 2.0-10.0 mg / L; and glacier water does not contain insoluble solids or suspended matter, and the total soluble solids content is 80-100 mg / L.

[0026] Using ultrapure water instead of glacier water, the extraction was carried out in the...

Embodiment 2

[0030] Example 2 Snow tea extract promotes the detection of fibroblast proliferation activity

[0031] Generally speaking, dermal aging is characterized by a decrease in the ability of the dermis to remove foreign chemicals, a thinning of the dermis, a decrease in the synthesis of collagen and elastin, an increase in decomposition, and an increase in the activity of decomposing enzymes. These phenomena are related to the reduction of fibroblasts and the decline or abnormality of secretion and synthesis functions. Human skin fibroblasts are the most important cells in the reticular layer of the skin dermis and one of the main repair cells after skin aging and cell damage. It can not only promote the migration, proliferation and differentiation of epidermal cells, but also secrete a large amount of collagen, elastin and various cell repair factors, and has a strong self-renewal ability to repair aging skin. If the active ingredient can promote the proliferation of fibroblasts o...

Embodiment 3

[0037] Example 3 ELISA method to detect the expression of hyaluronic acid in human fibroblasts

[0038] Hyaluronic acid is also an important component of the extracellular matrix, which has important functions of maintaining skin moisture content, regulating physiological water balance, promoting the transportation of nutrients and cell metabolism. Hyaluronic acid in the skin is gradually lost with age. Therefore, increasing the content of hyaluronic acid in the aging process of the skin is conducive to maintaining a high water content in the skin, keeping the skin moist and reducing the occurrence of wrinkles. If the active substance can promote the expression of hyaluronic acid and increase the content of hyaluronic acid in the extracellular matrix, it has a good moisturizing effect.

[0039] According to the method of Example 2, ultrapure water and glacier water were used to prepare DMEM medium containing 10% fetal bovine serum to cultivate human fibroblasts, and the extrac...

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Abstract

The invention belongs to the field of plant extraction and daily chemical, and particularly relates to a Thamnolia vermicularis/Lethariella cladonioides extract. The preparation method comprises: taking dried Thamnolia vermicularis/Lethariella cladonioides leaf powder, adding glacier water, taking the filtrate after ultrasonic extraction, and concentrating or carrying out freeze-drying. Accordingto the present invention, with the extraction method, the extraction effect is significantly improved, and the obtained Thamnolia vermicularis/Lethariella cladonioides extract can significantly promote the proliferation of skin fibroblasts, effectively improve the synthesis of type I collagen and improve the expression of hyaluronic acid by fibroblasts, can be used as an active component for preparing external application preparations for skin, can easily maintain the high water content and the moist state of skin and reduce the generation of wrinkles, can effectively promote the secretion ofcollagen, elastin and various cell repair factors by fibroblasts so as to repair aged skin and delay skin aging, and further has effects of anti-aging, moisture retention and anti-aging or repair.

Description

technical field [0001] The invention belongs to the field of plant extraction and daily chemical industry, and specifically relates to a snow tea extract and its application. Background technique [0002] Snow tea is a traditional health tea of ​​ethnic minorities in Northwest Yunnan. It is mainly distributed in the snow-covered plateau at an altitude of about 4,000 meters. It is a natural health drink and medicine on the snow-covered plateau. It is divided into white snow tea and red snow tea. White Snow Tea [Thamnolia vermicularis (Sw.) Ach] is the dry fronds of Thamnolia vermicularis (Sw.) Ach in the Theaceae. Baixue tea is shaped like white chrysanthemum petals, with a refreshing tea soup, unique flavor, cool in nature and sweet in taste; rich in Ca and Fe elements, it can be used to treat heat stroke, heart trouble, cough, neurasthenia and high blood pressure. [0003] Red snow tea [Lethariella cladonioides] has anti-inflammatory, sedative and pain-relieving functions,...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/96A61Q19/08A61Q19/00
CPCA61Q19/00A61Q19/08A61K8/965A61K8/97A61K2800/82A61K2800/84
Inventor 章漳蒋耀权周春霞宋肖洁方兆华河野善行
Owner JALA GROUP CORPORATION
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