Magnetic nanoparticle concentration and temperature measurement method based on paramagnetic shift

Abstract

The invention discloses a magnetic nanoparticle concentration and temperature measurement method based on paramagnetic shift. NMR (nuclear magnetic resonance) equipment is utilized for measuring chemical shift of a liquid sample containing paramagnetic particles so as to measure concentration and temperature of magnetic nanoparticles, and concentration and temperature measurement with high measurement accuracy is realized effectively. The paramagnetic nanoparticles are added to an NMR sample reagent, and the paramagnetic shift of the sample is obtained through NMR. Resonance frequency is acquired through the paramagnetic shift, magnetic susceptibility is acquired according to the relation between the resonance frequency and magnetic susceptibility of the magnetic nanoparticles, and concentration information and temperature information of the sample are further inversely solved according to the relation of the magnetic susceptibility of the magnetic nanoparticles with the concentrationand the temperature. According to simulation data, concentration measurement and high-accuracy temperature measurement of the magnetic nanoparticle sample can be effectively realized on the basis of the paramagnetic shift information.

Description

technical field [0001] The invention relates to the technical field of nanomaterial testing, in particular to a method for magnetic nanoparticle concentration and temperature based on paramagnetic displacement. Background technique [0002] Temperature is an important indicator of life activities. In medical treatment, many diseases can be treated by changing the temperature. Non-invasive visual temperature measurement for living organisms requires not only accurate temperature measurement, but also accurate positioning of temperature probes. Magnetic resonance imaging thermometry is a more promising temperature measurement method among the current non-invasive temperature measurement methods. However, it is mainly based on the temperature sensitivity of the relevant parameters of the current nuclear magnetic resonance imaging. Affected by some temperature-related parameters in human tissue, for example, the existence of fat will cause errors in temperature estimation, and ...

AI Technical Summary

Problems solved by technology

[0004] Magnetic nanoparticles such as iron oxide nanoparticles, as a substance with non-toxic performance to organisms, provide a possible solution for realizing visual temperature measurement inside the living body based on their temperature sensitivity. However, temperature measurement and concentration imaging based on magnetic nanoparticles are in the There are still challenges in high-precision measurement and high-spatial-resolution imaging, but the detection capability of nuclear magnetic resonance spectrometers has reached the ppm level

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