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Diagnostic marker of inferior myocardial infarction and/or anterior myocardial infarction

A myocardial infarction and marker technology, applied in the fields of molecular biology and medical diagnosis, can solve the problem of low sensitivity and achieve the effect of less harm to patients, strong specificity and convenient operation

Inactive Publication Date: 2018-10-19
TIANJIN CITY THIRD CENT HOSPITAL
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Problems solved by technology

Although NMR has the advantages of good repeatability and small differences between laboratories, its sensitivity is low

Method used

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  • Diagnostic marker of inferior myocardial infarction and/or anterior myocardial infarction
  • Diagnostic marker of inferior myocardial infarction and/or anterior myocardial infarction
  • Diagnostic marker of inferior myocardial infarction and/or anterior myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0098] Example 2 The diagnostic effect of lysophosphatidylcholines

[0099] 1. Draw the ROC curve and analyze the effect of four lysophosphatidylcholine substances, including LysoPC(14:0), LysoPC(15:0), LysoPC(17:0) and LysoPC(18:0) on the different incidence of myocardial infarction The precise diagnostic value of the site. The results of comparison between the anterior wall myocardial infarction group and the inferior wall myocardial infarction group showed that the diagnostic AUC of LysoPC(14:0) was 0.812 (95%CI); the diagnostic AUC of LysoPC(15:0) was 0.757 (95%CI); The diagnostic AUC of LysoPC(17:0) is 0.747 (95%CI); the diagnostic AUC of LysoPC(18:0) is 0.724 (95%CI), the results can be found in Figure 1-Figure 4 .

[0100] The results of comparison between the healthy control group and the anterior myocardial infarction group showed that the diagnostic AUC of LysoPC(14:0) was 0.678 (95%CI); the diagnostic AUC of LysoPC(15:0) was 1.000 (95%CI); 17:0) diagnostic AUC i...

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Abstract

The invention discloses a diagnostic marker of inferior myocardial infarction and / or anterior myocardial infarction. The diagnostic standard substance is a lysophosphatidylcholine substance; a high performance liquid chromatography-mass spectrometry detects that the contents of lysoPC (14:0), lysoPC (15:0), lysoPC (17:0) and lysoPC (18:0) in blood of patients suffering from the myocardial infarction are obviously lower than those in blood of normal people, and the contents of the lysoPC (14:0), the lysoPC (15:0), the lysoPC (17:0) and the lysoPC (18:0) in blood of patients suffering from the inferior myocardial infarction and the anterior myocardial infarction also have significant differences. According to research results, the invention develops a product for diagnosing the myocardial infarction, and the diagnostic product has high sensitivity and strong specificity and can be used in clinical popularization.

Description

technical field [0001] The present invention relates to the fields of molecular biology and medical diagnosis, in particular to diagnostic markers for inferior wall myocardial infarction and / or anterior wall myocardial infarction, and more specifically to lysophosphatidylcholine substances as inferior wall myocardial infarction and / or anterior wall myocardial infarction Use of diagnostic markers of infarction. Background technique [0002] Myocardial infarction is myocardial ischemic necrosis caused by a sharp decrease or interruption of coronary blood supply on the basis of coronary artery disease. Early and correct treatment is of great significance for reducing mortality, but clinical studies have shown that some patients with myocardial infarction have no specific early symptoms. The clinical manifestations and ECG changes, and there is no specific change in myocardial injury markers, so it is particularly urgent to find new specific and highly sensitive diagnostic indic...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813G01N2800/324
Inventor 张磊刘树业康华王宇凡范志娟田亚琼刘爽
Owner TIANJIN CITY THIRD CENT HOSPITAL
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