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Method for synthesizing oxazoline derivative by use of amide

A technology for synthesizing oxazoline and derivatives, applied in the direction of organic chemistry and the like, can solve the problems of high risk and low yield, and achieve the effects of low toxicity, low price and cost reduction

Active Publication Date: 2018-10-23
ANHUI COSTAR BIOCHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problem that the catalyst used in the molecular cyclization reaction is relatively expensive, dangerous, and low yield, the invention provides a method for synthesizing oxazole ring derivatives with amides, using amides and alkenes as reaction Raw materials and iodobenzene acetate and iodine are used as catalysts, the operation method is simple and safe, and the product yield is high

Method used

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  • Method for synthesizing oxazoline derivative by use of amide
  • Method for synthesizing oxazoline derivative by use of amide
  • Method for synthesizing oxazoline derivative by use of amide

Examples

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Effect test

Embodiment 1

[0021] 121g of benzamide, 56g of 2-butene, 256g of I 2 and 322g PhI(OAc) 2 The catalyst combination was added to 500mL of chloroform, stirred at 30°C, irradiated with a high-pressure mercury lamp for 6 hours, washed with water, and the organic phase was separated and dried, and the organic phase was distilled off under reduced pressure to obtain a solid, namely The oxazoline derivative with the structure shown in formula (III) has a product yield of 92%.

[0022]

Embodiment 2

[0024] 135g of p-toluamide, 56g of 2-butene, 256g of I 2 and 322g PhI(OAc) 2 The catalyst combination was added into 500mL of chloroform, stirred at 40°C, irradiated with a high-pressure mercury lamp for 6 hours, washed with water, and the organic phase was separated and dried, and the organic phase was distilled off under reduced pressure to obtain a solid, namely The oxazoline derivative with the structure shown in formula (III) has a product yield of 91%.

[0025]

Embodiment 3

[0027] 135g of p-toluamide, 69g of 2-pentene, 256g of I 2 and 322g PhI(OAc) 2 The catalyst combination was added into 500mL of chloroform, stirred at 40°C, irradiated with a high-pressure mercury lamp for 6 hours, washed with water, and the organic phase was separated and dried, and the organic phase was distilled off under reduced pressure to obtain a solid, namely The oxazoline derivative with the structure shown in formula (III) has a product yield of 91%.

[0028]

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PUM

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Abstract

The invention provides a method for synthesizing an oxazoline derivative by the use of amide, comprising the following steps: using a compound as shown in the formula (I) and a compound as shown in the formula (II) as starting materials, using iodosobenzene diacetate and iodine as catalysts, adding the materials into a solvent and stirring, carrying out irradiation reaction by the use of a high pressure mercury lamp for 5-8 h, washing, layering and taking an organic phase, and carrying out reduced pressure distillation on the organic phase to remove the solvent so as to obtain a solid, namelythe oxazoline derivative with the structure as shown in the formula (III). By using amide and olefin as reaction raw materials and using iodosobenzene diacetate and iodine as the catalysts, the operational method is simple and safe, and yield of the product is high.

Description

technical field [0001] The invention relates to the technical field of compound synthesis, in particular to a method for synthesizing oxazoline derivatives with amides. Background technique [0002] Oxazoline is a five-membered nitrogen-containing heterocyclic compound, and it and its derivatives have important industrial applications. Oxazoline derivatives can react with polyacids and polyamines, and the resulting resins can be used for pouring materials, powder coatings, etc.; can react with phenolic resins, and the prepared polyetheramides can be used in the aviation industry; can be used with benzoxazine The composite material obtained by the reaction can be used as a diaphragm of a fuel cell and the like. [0003] According to the different raw materials used, the synthetic methods of oxazoline and its derivatives can be divided into four categories. The first type is produced by the reaction of β-amino alcohols and carboxylic acids. The reaction uses organic boron co...

Claims

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Application Information

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IPC IPC(8): C07D263/12C07D413/04
CPCC07D263/12C07D413/04
Inventor 谷顺明梁锡臣赵广福邢建生孔顺喜
Owner ANHUI COSTAR BIOCHEM CO LTD
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