Nicotine composition for vaping devices and vaping devices employing the same

A nicotine and composition technology, which is applied in the field of nicotine compositions for electronic cigarette devices and electronic cigarette devices using the composition, can solve problems such as affecting the taste and experience of smoking electronic cigarette products, adverse effects on users, etc.

Inactive Publication Date: 2018-10-23
NEXT GENERATION LABS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These masking chemicals and the high volume of flavorings required to mask unpleasant tastes c

Method used

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  • Nicotine composition for vaping devices and vaping devices employing the same
  • Nicotine composition for vaping devices and vaping devices employing the same
  • Nicotine composition for vaping devices and vaping devices employing the same

Examples

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Comparison scheme
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example

[0073] The following examples are provided for illustrative purposes only and are not intended to limit the scope of any embodiments of the invention.

Synthetic example 1

[0074] Synthesis example 1——R, the synthesis of S nicotine

[0075]To a stirred solution of 1-vinyl-2-pyrrolidone (2) in dry THF was added 1 equivalent of potassium hydride under nitrogen atmosphere. The reaction mixture was stirred at room temperature for about 20 minutes, then ethyl nicotinate (1 equiv) was added, and the resulting mixture was stirred at 65 degrees Celsius for 24 hours. The reaction was cooled, then acidified using 5% HCl, then concentrated hydrochloric acid was added, and the resulting solution was refluxed for 48 hours. The pH was adjusted to 13 using sodium hydroxide, and the aqueous and organic layers of the resulting biphasic solution were separated 3 times using the same volume of dichloromethane. The separated combined extracts were dried over sodium sulfate, filtered and the solvent was evaporated to give an amorphous material. The amorphous material was dissolved in 3 parts of ethanol, then palladium on carbon (about 10%) was added, and the resu...

Synthetic example 2

[0076] Synthesis Example 2——Synthesis of R,S Nicotine

[0077] To a stirred solution of 1-vinyl-2-pyrrolidone (2) in dry THF / DMF (3 / 1 ) was added 1.2 equivalents of sodium hydride under nitrogen atmosphere. The reaction mixture was stirred at room temperature for about 20 minutes, then ethyl nicotinate (1 equiv) was added, and the resulting mixture was stirred at 65 degrees Celsius for 24 hours. The reaction was cooled, then acidified using 5% HCl, then concentrated hydrochloric acid was added, and the resulting mixture was refluxed for 48 hours. The pH was adjusted to 6 using sodium hydroxide, then excess dichloromethane was added and the layers were separated. The aqueous layer was extracted twice with excess dichloromethane, the extracts were combined and washed with water, then dried over sodium sulfate. The solution was then filtered and the solvent was removed using vacuum to give a brown solid. This solid was dissolved in ethanol (about 5 to about 10 parts), then 0...

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Abstract

A composition suitable for use in a vaping device includes a nicotine product that includes a synthetic nicotine that is substantially free of one or more contaminants and/or impurities normally associated with tobacco-derived nicotine. For example, the synthetic nicotine is substantially free of one or more of nicotine-1'- N-oxide, nicotyrine, nornicotyrine, 2',3-bipyridyl, cotinine, anabasine, and/or anatabine. The composition further comprises one or more pharmaceutically acceptable excipients, additives and/or solvents.

Description

Background technique [0001] Compositions currently used in e-cigarette devices (also referred to herein as "vaping devices" or "vaping devices") typically contain nicotine in dilute liquid form. The nicotine used in this composition is derived from a purified extract of tobacco leaves. These extracts are isolated in a semi-purified form along with many contaminants, many of which have been shown to cause serious disease in serious human systems, including cancer. For example, when tobacco-derived nicotine is purified to a level consistent with the monograph for purity set forth in the United States Pharmacopeia (USP) monograph, tobacco-derived nicotine still contains many contaminants, and since many contaminants are known carcinogens and addictive agents, so these pollutants are likely to cause problems for consumers. In addition, these contaminants contribute to the particular unpleasant taste and odor of commercially available products using tobacco-derived nicotine extra...

Claims

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Application Information

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IPC IPC(8): A61K9/12A24B15/16A24D1/14A61K9/14A61K9/72A61M15/06A24F40/10
CPCA24B15/167A24F40/10
Inventor M·阿诺德
Owner NEXT GENERATION LABS LLC
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