Lymphocyte bio-optical sensor based on photo-fluidic capillary micro-cavity and sensing method thereof

An optical sensor and lymphocyte technology, applied in the field of sensors, can solve the problems of relying on fluorescent labels, high maintenance requirements, and long detection time, and achieve the effect of compact structure, huge application value, and low cost

Inactive Publication Date: 2018-10-30
NANJING UNIV OF POSTS & TELECOMM
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Problems solved by technology

However, although flow cytometers are very accurate, they also have limitations such as reliance...

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  • Lymphocyte bio-optical sensor based on photo-fluidic capillary micro-cavity and sensing method thereof
  • Lymphocyte bio-optical sensor based on photo-fluidic capillary micro-cavity and sensing method thereof
  • Lymphocyte bio-optical sensor based on photo-fluidic capillary micro-cavity and sensing method thereof

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Embodiment Construction

[0039] Objects, advantages and features of the present invention will be illustrated and explained by the following non-limiting description of preferred embodiments. These embodiments are only typical examples of applying the technical solutions of the present invention, and all technical solutions formed by adopting equivalent replacements or equivalent transformations fall within the protection scope of the present invention.

[0040] The present invention discloses a lymphocyte bio-optical sensor based on optofluidic capillary microcavity, such as figure 1 As shown, it includes a frequency-sweeping laser 1, a capillary microcavity-micro-nano fiber coupling unit 2 for sensing and testing the cell solution, a photodetector 3 and a feedback control system 4, the frequency-sweeping laser 1, the capillary microcavity -The micro-nano optical fiber coupling unit 2, the photodetector 3 and the feedback control system 4 are connected to each other through optical fiber fusion coupl...

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Abstract

The invention discloses a lymphocyte bio-optical sensor based on a photo-fluidic capillary micro-cavity and a sensing method thereof. The sensor comprises a swept laser, a capillary micro-cavity-micro-nanofiber coupling unit, a photoelectric detector and a feedback control system, wherein the coupling unit is used for performing sensing test on a cell solution; the swept laser, the capillary micro-cavity-micro-nanofiber coupling unit, the photoelectric detector and the feedback control system are in coupled connection with one another by virtue of optical fiber fusion; the feedback control system is respectively and electrically connected with the photoelectric detector and the swept laser; the capillary micro-cavity-micro-nanofiber coupling unit is formed by vertically coupling micro-nanofibers and capillary micro-cavities mutually. According to the sensor in the invention, the capillary micro-cavity having tiny volume and high Q value serves as the lymphocyte sensing unit, and due tocontrol and interaction of light and micro-fluid in the micro-cavity, bio-optical lymphocyte sensing with advantages of being high in sensitivity, rapid in detection, label-free, compact in structure, high in integration level and low in cost is realized.

Description

technical field [0001] The invention relates to a lymphocyte bio-optical sensor based on an optofluidic capillary microcavity and a sensing method thereof, which can be used in the technical field of sensors. Background technique [0002] The ability to detect and quantify HIV is critical for physicians seeking to maximize treatment effectiveness, and one way to achieve this is by looking at CD4+ lymphocyte counts. The number of CD4+ cells in a healthy normal person is 1200 / μL. As the degree of AIDS infection deepens, this number will decrease at the same time. When it drops to 200 / μL, it will be diagnosed as AIDS. [0003] Currently, the count of CD4+ lymphocytes can be accurately achieved by flow cytometry. These instruments work by labeling CD4+ receptors with fluorescent antibodies and counting the resulting fluorescent signal. But although flow cytometers are very accurate in counting, they also have limitations such as reliance on fluorescent labels, high equipment c...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N21/41
CPCG01N21/41G01N33/53
Inventor 万洪丹陈冀景万成曹涵周权蔡一峰赵玉浩
Owner NANJING UNIV OF POSTS & TELECOMM
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