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Ciprofloxacin hydrochloride dry powder inhalation and preparation method thereof

A technology of ciprofloxacin hydrochloride and dry powder inhalation, which is applied in the field of medicine to achieve the effects of increased drug loading, high emptying rate and good inhalation performance

Active Publication Date: 2021-03-09
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Due to the limitations of the current research, a ciprofloxacin hydrochloride dry powder inhaler with good inhalation and emptying performance and high drug loading is urgently needed in the market.

Method used

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  • Ciprofloxacin hydrochloride dry powder inhalation and preparation method thereof
  • Ciprofloxacin hydrochloride dry powder inhalation and preparation method thereof
  • Ciprofloxacin hydrochloride dry powder inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment prepares a kind of ciprofloxacin hydrochloride dry powder inhalation, which is composed of ciprofloxacin hydrochloride as the active ingredient, carrier mannitol and silk fibroin, and the mass percentages of the three are 20%, 40%, and 40% respectively. Drugs accounted for 20%.

[0047] The preparation method of above-mentioned ciprofloxacin hydrochloride dry powder inhalation comprises the steps:

[0048] (1) Dissolving silk fibroin in deionized water, adding ciprofloxacin hydrochloride and mannitol, and stirring to form a uniform solution;

[0049] (2) adopt spray drying technology to carry out spray drying to above-mentioned solution, obtain ciprofloxacin hydrochloride dry powder inhalation; Wherein the technological condition of spray drying is: inlet temperature (being drying temperature): 110 ℃; Atomization pressure: 15kPa; Liquid velocity: 8.30mL / min; solid-liquid content: 25mg / mL; gas flow: 0.60~0.65m 3 / min, the nozzle diameter is 0.71mm;

[...

Embodiment 2

[0052] This example prepares a ciprofloxacin hydrochloride dry powder inhaler, the components of which are basically the same as those in Example 1, the difference being that in the process conditions of spray drying, the inlet temperature is 120°C.

Embodiment 3

[0054] In this example, a ciprofloxacin hydrochloride dry powder inhaler was prepared, the components of which were basically the same as those in Example 1, the difference being that in the process conditions of spray drying, the inlet temperature was 130°C.

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Abstract

The invention discloses a ciprofloxacin hydrochloride dry powder inhaler and a preparation method thereof. The dry powder inhaler is prepared from medicine and binary auxiliary materials, and the medicine accounts for 80%-20% of the dry powder inhaler, wherein, two The mass percentage of the primary auxiliary material in the dry powder inhaler is 20%-80%. The binary auxiliary material is composed of mucus thinner and bioadhesive protein; the mucus thinner is mannitol, ambroxol hydrochloride, cysteine, bromhexyl hydrochloride At least one of novel; the bioadhesive protein is at least one of silk fibroin, albumin or spider silk protein. The powder of the dry powder inhaler prepared by the invention has good fluidity and good aerodynamic performance, can target the drug to the lungs, effectively increase the local concentration of the drug, and has mucus dilution and bio-mucosal adsorption characteristics, and is especially suitable for Patients with bronchiectasis caused by chronic infection of the lungs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ciprofloxacin hydrochloride dry powder inhaler and a preparation method thereof. Background technique [0002] Bronchiectasis is a clinically very common respiratory disease, which occurs in patients with chronic pulmonary infection, especially chronic obstructive pulmonary disease (COPD) and cystic fibrosis (Cystic Fibrosis, CF). ) patients are more common. The condition of such patients is characterized by repeated inflammation and infection of the lungs, forming a vicious cycle. Repeated inflammation and infection of the lungs cause the mucus layer of the mucous membrane to thicken, which provides a good nutritional environment for the growth of bacteria, and at the same time forms a mucosal barrier to reduce the therapeutic effect of drugs. [0003] The treatment of inhaled antibiotics has become one of the first choice clinical treatment options for the trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K9/14A61K47/42A61K47/26A61K31/496A61P11/00A61P31/04
CPCA61K9/0075A61K9/145A61K9/146A61K31/496A61K47/26A61K47/42A61P11/00A61P31/04
Inventor 刘春霞林玲李国成吕立余晓霞吴巧利林英周永恒
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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