42 results about "Mucus layer" patented technology

A nanotube device comprises a gel matrix that includes microcapsules and functionalized nanotubes, or other functionalized nanostructures incorporated into said gel matrix. Pharmaceutical compositions and methods of treatment comprising same. The pharmaceutical compositions of the present invention enable the specific and targeted delivery of therapeutic agents such as DNA molecules, peptides, including antibodies, drug molecules (e.g. small organic molecules), while offering sufficient resistance towards mucus layer of the intestine and high concentrations of enzymes and other molecules found in the blood stream and the GI tract.

Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector enables efficient gene transfer to native mucus-layered airway epithelial cells by briefly contacting the vector with the cells. Furthermore, the vector can introduce genes to not only apical surfaces but also submucosal glands where CFTR primarily expresses. The vector can thus be used for gene therapy of CF, a CFTR-deficient disease.

The invention provides a functional mixed additive and application thereof. The functional mixed additive comprises Brady yeast, and the functional mixed additive can obviously improve piglet diarrhea, promote piglet growth and improve piglet survival rate. Under the condition of weaning or other stress of piglets, feed added with the functional mixed additive can effectively protect intestinal tracts, promote the integrity of epithelial cell morphology and structure, good growth of microvilli, tight epithelial connection and reasonable thickness of a mucus layer, improve the digestion and absorption of energy and nutrients of the piglets, and further promote the growth and development of the piglets. The functional mixed additive can effectively replace antibiotics, and the problems of influence of the antibiotics on ecological environment and drug resistance are solved.

Compositions and methods for improving transperitoneal oxygen uptake during peritoneal ventilation for extrapulmonary oxygenation of an organism or individual organs in preferably life-threatening case of need, such as pulmonary failure or circulatory shock, are disclosed. Such deficiencies can be addressed by transperitoneal administration of oxygen via a gas introduced into the abdominal cavity. A liquid, preferably aqueous, composition including an oxygen carrier such as hemoglobin is used, which, surprisingly, is capable of increasing the effectiveness of the diffusion of the oxygen administered by a one-time or repeated filling or continuous flushing of the abdominal cavity. An oxygen carrier, such as hemoglobin or derivatives thereof, is used for the manufacture of a composition for improvement of the diffusion of oxygen (gas) introduced into mucus layers of the peritoneum, preferably to enhance the diffusion of oxygen in transperitoneal ventilation.

The invention discloses policosanol dropping pills and the preparation method thereof, which prepare solid dispersoid through water-soluble substrate and enable the policosanol to be in the state of ultrafine particles, microcrystallines or molecular, so as to improve the dissolution quantity and dissolution rate. The state that the medicine dissolving property is good cannot always ensure the bioavailability is good; proper amount of surfactant-type absorption enhancer is added to the policosanol dropping pill preparation to improve the diffusion in the mucosal mucus layer in cellular membrane, so as to enable the policosanol dropping pill to quickly penetrate the biological membrane and increase absorption. The policosanol dropping pill and the preparation method have the advantages of high dissolution rate, high bioavailability, simple process, convenient product application and carrying, being applicable to the treatment of hypercholesterolemia, anti-platelet aggregation, ischemia, thrombosis and complications of atherosclerosis, improving the exercise performance and response sensitivity.

The present invention relates to in vitro adhesion modules that allow growth, stabilization and study of microbial communities that adhere to and colonize host-related surfaces, that mimic transport of chemical compounds across epithelial surfaces and simulate host-microorganism interactions and adaptation. It includes the provision of micromolar amounts of oxygen via the basal side of a mucus layer towards the adhered microorganisms thus establishing the microaerophilic conditions prevailing at the base of a biofilm. It can also include cells, simulating the host, in a chamber on the basal side of a functional layer comprising said mucus layer. The adhesion module of the present invention can be placed between the different compartments of the SHIME—the Simulator of the Human Intestinal Microbial Ecosystem. An extension of the SHIME is made where the duodenum, jejunum and ileum are separately mimicked.

The invention relates to a reducing responsive targeted polymeric micelle for mucus penetration and a preparation method of the polymeric micelle. An amphiphilic polymeric combination is formed by combining PLGA (poly (lactic-co-glycolic acid)) and PEG (polyethylene glycol) through a reducing responsive disulfide bond, and the reducing responsive polymeric micelle is formed by assembling the polymeric combination, so that excellent performances of mucus penetration, reducing responsive bond breaking and targeted cell-mediated endocytosis are achieved, and the effective grain size of the polymeric micelle is 70-110nm, so that the polymeric micelle is more uniform in grain size; the surface of the micelle which is covered in PEG is neutral, so that cytotoxicity is low; the polymeric micelle is capable of penetrating into a bottom cell layer in a mucus layer and a glutathione solution is injected as the polymeric micelle reaches the bottom cells, at which time the reducing responsive disulfide bond is broken, PEG protection is removed, covered targeted folic acid is exposed and is subjected to specific combination with a folic acid receptor which undergoes over-expression on the surface of a cell membrane of focus cells, and an endocytosis action is mediated by virtue of the folic acid receptor, so that cell-entering efficiency of nano carriers is improved and more carriers enter the cells to take a sustained / controlled-release effect on medicines; therefore, a therapeutic effect is enhanced.

The invention discloses a composition for treating the inflammatory bowel disease, and belongs to the field of medicines. The composition comprises Mythic Fungus, Salvia miltiorrhiza, ginseng, threonine, serine, cysteine, vitamin C, vitamin E, vitamin A and beta-carotene. Mythic Fungus, Salvia miltiorrhiza and ginseng have the efficacy of enhancing human body blood supply and oxygen supply; threonine, serine and cysteine are composition parts of mucoproteins; and vitamin C, vitamin E, vitamin A and beta-carotene have oxyradical activation repression, oxyradical removal and human body cell protection effects. The composition provides nutrition, oxygen and raw materials for generation, updating and restoration of goblet cells and an intestinal tract surface mucus layer barrier composed of mucoproteins secreted by the goblet cells. The composition has obvious inflammation termination, intestinal tract tissue restoration and human body normal intestinal tract surface mucus layer barrier construction effects, and is an effective composition for treating the inflammatory bowel disease.

The invention belongs to pharmaceutical preparations containing protein materials. It is an oral preparation of intestinal trefoil factor, which is characterized in that it contains intestinal trefoil factor as a pharmacodynamic active component, and also contains intestinal trefoil factor activator and intestinal trefoil factor protective agent. It is clinically used for the treatment of gastrointestinal ischemia-hypoxic injury, such as peptic ulcer, radiation enteritis, chronic gastritis, enteritis and other diseases caused by various reasons, and can rapidly promote the proliferation of gastrointestinal epithelial cells, Stabilizes the gastrointestinal mucus layer, does not interfere with glucose metabolism and promote gluconeogenesis, and has no side effects of promoting the expression of bacterial drug resistance genes and promoting the growth of tumor cells.

The invention discloses a high-performance adhesive material and a preparation method thereof. The high-performance adhesive material is successively formed by a bottom PMDS layer, a carbon fiber cloth layer, a top PDMS layer and an elm bark mucus layer from bottom to top, wherein the elm bark mucus layer is prepared from elm bark mucus, and the bottom and top PDMS materials are formed by mixing liquid silicone rubber and silicone rubber curing agent. The preparation method comprises the following steps: cleaning elm barks, extracting elm bark mucus, and compositing with PDMS / carbon fiber cloth. The high-performance adhesive material solves the technical problems of the traditional adhesive material that the viscosity is good only for a dry and clean contact surface and the viscosity is generally poor for the wet, smooth and dirty contact surface. The adhesive material disclosed by the invention has effects of dual use in dry and wet environment and strong viscosity, and the invention provides a novel material and a novel concept for the geological mining and rescue in a severe environment, and has an important significance in the enlarging an application environment and field of the adhesive material.

The invention discloses an eleventh formula for treating inflammatory bowel disease, and belongs to the field of medicine. The formula comprises the components of salvia miltiorrhiza, threonine, vitamin C, vitamin E, vitamin A and beta-carotene. Salvia miltiorrhiza has the efficacies of enhancing human blood supply and oxygen supply; threonine is a constituent part of mucoproteins; vitamin C, vitamin E, vitamin A and beta-carotene have the effects of blocking and inhibiting the activity of oxygen free radicals, scavenging the oxygen free radicals and protecting human body cells. The formula provides nutrients, oxygen and raw materials for generation, updating and repairing of goblet cells and for goblet cell secreting of the mucoproteins to construct an intestinal surface mucous layer barrier. The formula has obvious effects on terminating inflammation, repairing intestinal tissues and building the human body normal intestinal surface mucus layer barrier, and is an effective formula for treating inflammatory bowel disease.

The invention discloses a combination formula for adjusting mucus layer barriers on the surfaces of respiratory tracts and digestive tracts and belongs to the field of drugs. The combination formula comprises rhizoma polygonati odorati, threonine, serine, cysteine and cystine. The rhizoma polygonati odorati has the effects of enhancing blood supply and oxygen supply of the human body, and the threonine, the serine and the cysteine are the main components of mucoprotein. The combination formula can provide nutrition, oxygen and raw materials for the generation, updating, repairing and mucoprotein secretion of mucus cells like goblet cells and mucus glands of the digestive tracts and the respiratory tracts. In addition, the combination formula can effectively construct the normal mucus layer barriers on the surfaces of the digestive tracts and the respiratory tracts of the human body, prevent antigen from approaching, contacting, adhering and entering tissues of the digestive tracts and the respiratory tracts, block abnormal immune response, stop inflammation, repair the tissues of the digestive tracts and the respiratory tracts and prevent and cure diseases of the digestive system and the respiratory system.

The invention discloses a composition for treating the inflammatory bowel disease, and belongs to the field of medicines. Intestinal epidermal goblet cells are reinforced to construct a normal intestinal surface mucus layer barrier in order to prevent intestinal antigens from approaching, contacting, adhering and entering intestine wall tissues, so abnormal immune response and inflammation generation are blocked out. Salvia miltiorrhiza has the efficacy of enhancing human body blood supply and oxygen supply; threonine is a composition part of mucoproteins, and is an essential amino acid in human bodies; and glutamine is the main energy source of intestinal mucosa. The composition provides nutrition, oxygen and raw materials for generation, updating and restoration of goblet cells and an intestinal tract surface mucus layer barrier composed of mucoproteins secreted by the goblet cells. The composition obtained through combining Salvia miltiorrhiza, ginseng and glutamine has obvious inflammation termination, intestinal tract tissue restoration and human body normal intestinal tract surface mucus layer barrier construction effects, and is an effective formula for treating the inflammatory bowel disease.

The invention relates to a reduction-responsive targeting polymer micelle for mucus penetration and a preparation method thereof. Combining PLGA and PEG through reduction-responsive disulfide bonds to form an amphiphilic polymer conjugate, and post-assembly to form reduction-responsive micelles to achieve good mucus permeability, reduction-responsive bond breaking performance and targeting cell-mediated The performance of endocytosis, and the effective particle size is 70-110nm, and the particle size is more uniform; due to the coating of PEG, the surface of micelles is neutral, and the cytotoxicity is low, and it can penetrate into the bottom cell layer in the mucus layer and reach the bottom cells After injection of glutathione solution, the reduction-responsive disulfide bond breaks, the PEG protection is removed, and the coated targeted folic acid is exposed, which specifically binds to the folic acid receptor overexpressed on the cell membrane surface of the lesion cell, and is mediated by folic acid Receptor-mediated endocytosis improves the efficiency of nanocarriers entering cells, allowing more carriers to enter cells for slow and controlled release of drugs, achieving better therapeutic effects.

The invention discloses a combination formula for adjusting mucus layer barriers on the surfaces of respiratory tracts and digestive tracts and belongs to the field of drugs. The combination formula comprises ganoderma lucidum, radix astragali seu hedysari, threonine, serine, cysteine and cystine. The ganoderma lucidum and the radix astragali seu hedysari have the effects of enhancing blood supply and oxygen supply of the human body, and the threonine, the serine and the cysteine are the main components of mucoprotein. The combination formula can provide nutrition, oxygen and raw materials for the generation, updating, repairing and mucoprotein secretion of mucus cells like goblet cells and mucus glands of the digestive tracts and the respiratory tracts. In addition, the combination formula can effectively construct the normal mucus layer barriers on the surfaces of the digestive tracts and the respiratory tracts of the human body, prevent antigen from approaching, contacting, adhering and entering tissues of the digestive tracts and the respiratory tracts, block abnormal immune response, stop inflammation, repair the tissues of the digestive tracts and the respiratory tracts and prevent and cure diseases of the digestive system and the respiratory system.

The invention discloses methods for preparing and detecting a chyle particle migration model in a mucus layer, and relates to the technical field of preparation and detection of particle migration models, and the preparation method comprises the following steps: S1, obtaining animal intestinal mucus; S2, preparing artificial chyle, and storing the artificial chyle under a certain condition; s3, adding the intestinal mucus into a sample bottle, and then adding the artificial chyle. According to the preparation and detection methods of the chyle particle migration model in the mucus layer, the problems of long conventional animal experiment period, high operation difficulty, ethical morality and the like are solved.

The invention discloses a combined formula for adjusting the mucus layer barrier on the surface of digestive tracts and respiratory tracts, which belongs to the field of medicines. The present invention uses ganoderma lucidum, Polygonatum polygonatum, threonine, serine, cysteine ​​and cystine as a combined formula. Ganoderma lucidum and Polygonatum can enhance the blood supply and oxygen supply of the human body; threonine, serine, and cysteine ​​are the main components of mucin. The combination formula of the present invention provides nutrients, oxygen and raw materials for mucous cells such as goblet cells and mucus glands in digestive tracts and respiratory tracts, and for the generation, renewal, repair and secretion of mucin; Barrier, preventing antigens from approaching, contacting, adhering and entering the digestive tract and respiratory tract tissue, blocking abnormal immune response, terminating inflammation, repairing digestive tract and respiratory tract tissue, effective combination formula for preventing and treating digestive system and respiratory system diseases .

This disclosure relates to metal nanoparticle compositions and methods for treating respiratory infections associated with cystic fibrosis. An amount of nonionic, ground state metal nanoparticles are administered to a patient via inhalation. The metal nanoparticles have properties that enable effective transport through the viscous mucus layer to the epithelia and surrounding tissues, killing or deactivating infecting microbes at the targeted respiratory tissue and throughout the overlying mucus layer.

The invention discloses a combination formula for regulating surface mucus layer barriers of a digestive duct and a respiratory tract and belongs to the field of medicines. The combination formula comprises Wolfiporia extensa, threonine, serine, cysteine, cysteine and proline, wherein the Wolfiporia extensa has the effect of enhancing blood supply and oxygen supply; threonine, serine, cysteine and proline are main constituents of mucoproteins. The combination formula provides nutrition, oxygen and raw materials for generation, regeneration, repair and mucoprotein of mucous glands and mucilage cells such as goblet cells and the like of the digestive duct and the respiratory tract; the combination formula is an effective combination formula for constructing normal surface mucus layer barriers of the digestive duct and the respiratory tract of a human body, preventing antigens from getting close to, being contacted with, adhering to and entering the digestive duct and respiratory tract tissue, blocking abnormal immune response, terminating inflammation, repairing the digestive duct and respiratory tract tissue and preventing and treating diseases of a digestive system and a respiratory system.

The invention discloses a method for efficiently extracting internal mucus layers of arabidopsis thaliana, belonging to the field of polysaccharide extraction. In the method disclosed by the invention, the internal mucus layers are extracted using ultrasonic. The method is economical and simplifies operation, wherein the extraction solution is water, and a large quantity of seed coat mucus layers can be obtained without desalting treatment; and in extraction using an acid-alkali-salt process, residual salt needs to be removed. The time is saved, wherein the extraction time using a vibration process and an alkali salt process is generally 1-2h and desalting is also needed in later period, and the method disclosed by the invention can finish the extraction within 20s. The extraction efficiency is high, wherein a large quantity of residual mucus layers are shown after the seed extracted by the vibration process and acid-alkali-salt process is dyed by ruthenium red; and after the extraction using the method disclosed by the invention, basically no residue of mucus layers exists. The method has the advantages of high efficiency, stability, good reproducibility and the like, can extract the mucus layers to the greatest degree and realize more accurate analysis of the mucus layers, and promotes the study on the formation mechanism of mucus layers; and in the chemical industry, the method can shorten the extraction time and reduce the cost.

The invention discloses a preparation technology of nano-micelles for conveying anti-tumor medicines through oral administration, namely a preparation method of nano-micelles with mucous layer permeation and P-gp inhibition dual effects. Chitosan, quercetin and 6-phosphogluconic acid are used as raw materials to prepare an amphiphilic chitosan-quercetin succinate-6-phosphogluconic acid copolymer through a condensation and esterification method and a target product is synthesized through a self-assembling technology; the nano-micelles have a good mucous layer permeation capability and also has the P-gp inhibition effect; the oral administration conveying efficiency of the anti-tumor medicines can be effectively improved. The nano-micelles can be used for medical biological materials and medicine carriers and have good research and development application prospects.

The invention discloses a combination formula for adjusting mucus layer barriers on the surfaces of respiratory tracts and digestive tracts and belongs to the field of drugs. The combination formula comprises radix acanthopanacis semticosi, threonine, serine, cysteine and cystine. The radix acanthopanacis semticosi has the effects of enhancing blood supply and oxygen supply of the human body, and the threonine, the serine and the cysteine are the main components of mucoprotein. The combination formula can provide nutrition, oxygen and raw materials for the generation, updating, repairing and mucoprotein secretion of mucus cells like goblet cells and mucus glands of the digestive tracts and the respiratory tracts. In addition, the combination formula can effectively construct the normal mucus layer barriers on the surfaces of the digestive tracts and the respiratory tracts of the human body, prevent antigen from approaching, contacting, adhering and entering tissues of the digestive tracts and the respiratory tracts, block abnormal immune response, stop inflammation, repair the tissues of the digestive tracts and the respiratory tracts and prevent and cure diseases of the digestive system and the respiratory system.

The invention belongs to the technical field of medicine, and relates to the application of a class of maleimide prodrugs targeting mucin in promoting bioadhesion and improving oral drug absorption. The structural formula of the maleimide type prodrug is as shown in (I): wherein, n=2~8; X is O, N; The prodrug compound has high drug loading, good stability, safety and available for oral administration. The maleimide group it carries can specifically bind to the mucin in the mucus layer in the gastrointestinal tract to form a mucin-prodrug complex, prolong the residence time of the drug in the gastrointestinal tract, and improve the adsorption-absorption Concentration gradients across sites facilitate passive diffusion, thereby enhancing oral absorption. The invention is a novel maleimide type prodrug with bioadhesive effect, which is used to improve the oral absorption of drugs.

The invention discloses a combination formula for treating the inflammatory bowel disease, and belongs to the field of medicines. The formula comprises Mythic Fungus, Salvia miltiorrhiza, ginseng, Poria cocos, glutamine, threonine, serine and cysteine. Mythic Fungus, Salvia miltiorrhiza, ginseng and Poria cocos have the efficacy of enhancing human body blood supply and oxygen supply; glutamine is the main energy source of intestinal mucosa; and threonine, serine and cysteine are composition parts of mucoproteins. The combination formula provides nutrition, oxygen and raw materials for generation, updating and restoration of goblet cells and an intestinal tract surface mucus layer barrier composed of mucoproteins secreted by the goblet cells. The combination formula has obvious inflammation termination, intestinal tract tissue restoration and human body normal intestinal tract surface mucus layer barrier construction effects, and is an effective composition for treating the inflammatory bowel disease.

The invention discloses a combination formula for adjusting mucus layer barriers on the surfaces of respiratory tracts and digestive tracts and belongs to the field of drugs. The combination formula comprises rhizoma atractylodis macrocephalae, threonine, serine, cysteine and cystine. The rhizoma atractylodis macrocephalae has the effects of enhancing blood supply and oxygen supply of the human body, and the threonine, the serine and the cysteine are the main components of mucoprotein. The combination formula can provide nutrition, oxygen and raw materials for the generation, updating, repairing and mucoprotein secretion of mucus cells like goblet cells and mucus glands of the digestive tracts and the respiratory tracts. In addition, the combination formula can effectively construct the normal mucus layer barriers on the surfaces of the digestive tracts and the respiratory tracts of the human body, prevent antigen from approaching, contacting, adhering and entering tissues of the digestive tracts and the respiratory tracts, block abnormal immune response, terminate inflammation, repair the tissues of the digestive tracts and the respiratory tracts and prevent and cure diseases of the digestive system and the respiratory system.

The invention discloses an inhalable effervescent powder mist and its application in the preparation of medicines for treating infectious pneumonia, belonging to the technical field of medicine. The inhalable effervescent powder mist comprises active agent and effervescent agent, and the mass ratio of active agent and effervescent agent is 1:1~50; Described effervescent agent is made up of acid and alkali, and described acid comprises at least Diketopiperazine can optionally include one or more of citric acid, malic acid, fumaric acid, maleic acid, succinic acid or tartaric acid, and the base is selected from sodium carbonate, potassium carbonate, sodium bicarbonate or One or more of potassium bicarbonate. The effervescent powder mist of the present invention can provide a driving force for the active agent, that is, the drug powder, to accelerate the dissolution of the drug in the mucus layer on the surface of the bronchi and alveoli, and avoid macrophages from engulfing and clearing the drug.

The invention discloses a method for efficiently extracting internal mucus layers of arabidopsis thaliana, belonging to the field of polysaccharide extraction. In the method disclosed by the invention, the internal mucus layers are extracted using ultrasonic. The method is economical and simplifies operation, wherein the extraction solution is water, and a large quantity of seed coat mucus layers can be obtained without desalting treatment; and in extraction using an acid-alkali-salt process, residual salt needs to be removed. The time is saved, wherein the extraction time using a vibration process and an alkali salt process is generally 1-2h and desalting is also needed in later period, and the method disclosed by the invention can finish the extraction within 20s. The extraction efficiency is high, wherein a large quantity of residual mucus layers are shown after the seed extracted by the vibration process and acid-alkali-salt process is dyed by ruthenium red; and after the extraction using the method disclosed by the invention, basically no residue of mucus layers exists. The method has the advantages of high efficiency, stability, good reproducibility and the like, can extract the mucus layers to the greatest degree and realize more accurate analysis of the mucus layers, and promotes the study on the formation mechanism of mucus layers; and in the chemical industry, the method can shorten the extraction time and reduce the cost.

Products of manufacture and methods for in situ removal and / or disruption of biofilms, such as gastral cavity biofilms, and for treating or ameliorating biofilm-related diseases, infections and conditions, including gastrointestinal (GI) cavity infections, are provided. Devices and apparatus for in situ removal, disruption and / or disruption of biofilms, such as gastral cavity biofilms, and methods of using the same are provided. In alternative embodiments, devices and apparatus and methods are provided for enhancing a biofilm solubilizing or disrupting agent, or for administering a biofilm solubilizing or disrupting agent, where in alternative embodiments, a biofilm comprises a gastral cavity'non-agitation layer ', an adhesion layer, or a gastral cavity mucus layer; or the biofilm comprises a matrix or a DNA-containing layer, or alternatively, the biofilm comprises a polysaccharide gastral peripheral layer.

The present invention relates to nanomicelles comprising a complex of a poly gamma-glutamic acid of which a part of the carboxylic group is substituted by an amine group and an oleophilic compound and, more specifically, to nanomicelles comprising a complex of a poly gamma-glutamic acid of which a part of the carboxylic group is substituted by an amine group and an oleophilic compound, a method for producing the same, and a drug delivery system using mucus layer-adhesive properties of the nanomicelles. According to the present invention, when the nanomicelles drug delivery system on the basis of the poly gamma-glutamic acid, which is a biogenous natural polymer, is utilized in the field of drug delivery to a mucus layer region, the nanomicelles drug delivery system can improve biostability and effectiveness of a drug.

The invention provides a lung gene delivery system as well as a preparation method and application thereof. The lung gene delivery system has the capability of efficiently overcoming mucus layers andcell membrane barriers. RBP and cis-aconitic anhydride are used for preparing RC, a polymer solution and a nucleic acid solution are mixed and incubated, then the RC solution is added, and incubationis conducted to obtain the lung gene delivery system. An RCDsT nano-composite is used for treating ALI diseases, after the RCDsT nano-composite is injected into the lung airway, the RCDsT nano-composite can effectively penetrate through the mucus layer and is effectively taken in by cells, and therefore, siTNF-alpha and RBP combined anti-inflammatory treatment for ALI is achieved. Briefly speaking, the work provides another method for solving the contradiction between mucus permeation and cellular uptake, and a new method capable of realizing oligopeptide / siRNA co-delivery is provided for treating ALI in a mode of direct administration in the lung airway.