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Policosanol drop pill and preparation method thereof

A technology of policosanol and dripping pills, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of difficult biological activity, poor bioavailability, poor solubility, etc., and achieve improved Bioavailability, low production cost, high bioavailability effect

Inactive Publication Date: 2009-03-25
广西万寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, policosanol is a fat-soluble substance with extremely small solubility in water, poor solubility and poor bioavailability, and difficult to exert biological activity

Method used

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  • Policosanol drop pill and preparation method thereof
  • Policosanol drop pill and preparation method thereof
  • Policosanol drop pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of policosan drop pills (1)

[0048] Prescription (specification: containing policosanol 2.00mg / pill, pill weight 45mg)

[0049] Polycohol 10.0g

[0050] Macrogol 1500 50.2g

[0051] Polyethylene glycol 6000 150.0g

[0052] Tween 20 14.8g

[0053] A total of 5000 capsules were made.

[0054] Experimental method: take 50.2g of polyethylene glycol 1500, 150.0g of polyethylene glycol 6000, and 14.8g of Tween 20, and then add 10.0g of policosanol raw material powder, stir and mix evenly, and use electric heating to prepare The mixture of raw and auxiliary materials is heated to a molten state, and a special dropping pill machine is used to adjust the dropper temperature and keep it at 85°C (error <2%); using methyl silicone oil as a condensing agent, adjust the refrigeration control system of the dropping pill machine Keep the temperature of the condensing agent at 20 to -5°C (error <5%), then drip according to the method given in the previous preparation p...

Embodiment 2

[0059] Preparation of policosan dropping pills (2)

[0060] Prescription (specification: containing policosanol 2.0mg / pill, pill weight 40mg)

[0061] Polycohol 10.0g

[0062] Macrogol 2000 79.7g

[0063] Macrogol 4000 100.0g

[0064] Benzaze 58 10.3g

[0065] A total of 5000 capsules were made.

[0066] Experimental method: Take 79.7g of polyethylene glycol 2000, 100.0g of polyethylene glycol 4000, 10.3g of Benze 58, and then add 10.0g of policosanol raw material powder, stir and mix evenly, and use electric heating to prepare The mixture of raw and auxiliary materials is heated to a molten state, and a special dropping pill machine is used to adjust the dropper temperature and keep it at 85°C (error <2%); using methyl silicone oil as a condensing agent, adjust the refrigeration control system of the dropping pill machine Keep the temperature of the condensing agent at 20 to -5°C (error <5%), then drip according to the method given in the previous preparation process, ta...

Embodiment 3

[0071] Preparation of policosanol dropping pills (3)

[0072] Prescription (specification: policosanol 1.0mg / pill, pill weight 34.2mg)

[0073] Polycohol 10.0g

[0074] Macrogol 2000 57.6g

[0075] Macrogol 4000 142.4g

[0076] Polyethylene glycol 6000 100.0g

[0077] Benzaze 35 32.4g

[0078] A total of 10,000 capsules were made.

[0079] Method: Take 57.6g of polyethylene glycol 2000, 142.4g of polyethylene glycol 4000, 100.0g of polyethylene glycol 6000, and 32.4g of Benze 35 and mix them evenly, then add 10.0g of policosanol raw material powder, stir and mix evenly , use electric heating to heat the mixture of raw and auxiliary materials to a molten state, use a self-made special pilling machine, adjust the dripper temperature and keep it at 85°C (error <2%); use methyl silicone oil as the condensation Adjust the refrigeration control system of the dropping pill machine to keep the temperature of the condensing agent at 20 to -5°C (error <5%), and then drip according...

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Abstract

The invention discloses policosanol dropping pills and the preparation method thereof, which prepare solid dispersoid through water-soluble substrate and enable the policosanol to be in the state of ultrafine particles, microcrystallines or molecular, so as to improve the dissolution quantity and dissolution rate. The state that the medicine dissolving property is good cannot always ensure the bioavailability is good; proper amount of surfactant-type absorption enhancer is added to the policosanol dropping pill preparation to improve the diffusion in the mucosal mucus layer in cellular membrane, so as to enable the policosanol dropping pill to quickly penetrate the biological membrane and increase absorption. The policosanol dropping pill and the preparation method have the advantages of high dissolution rate, high bioavailability, simple process, convenient product application and carrying, being applicable to the treatment of hypercholesterolemia, anti-platelet aggregation, ischemia, thrombosis and complications of atherosclerosis, improving the exercise performance and response sensitivity.

Description

technical field [0001] The invention relates to a preparation method of a drop pill pharmaceutical preparation, in particular to a policosanol drop pill and a preparation method thereof. Background technique [0002] Policosanol is named according to the meaning of Policosanol, also known as policosanol, policosanol, high-carbon alkanol, montanol, and is also called sugar cane element, sugar cane element, etc. in Taiwan, it is a high-grade fat A mixture of primary alcohols. It can be purified by saponification from animal and plant waxes such as sugarcane wax, rice bran wax, and beeswax. The policosanol produced from sucrose wax is mainly composed of octacosanol, accounting for about 60-75% of the total, and the rest are hexacosanol, triacontanol, tetracosanol, tetracosanol, Heptadecanol, nonacosanol, tricosanol and tetracosanol, etc. [0003] Sugarcane Policosanol (SCP), as a cholesterol-lowering drug, was approved for marketing in Cuba in 1991. Together with cigars, it ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/045A61K47/34A61P3/06A61P9/00A61P7/02A61K47/10A61K47/26
Inventor 慕丽群雷同康黄垚林志锦
Owner 广西万寿堂药业有限公司
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