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Ophthalmic drug combination and preparation and application methods thereof

A composition and drug technology, applied in the field of ophthalmic pharmaceutical composition and its preparation, can solve the problems of no dry eye, no therapeutic effect, ocular surface toxicity and side effects, etc.

Active Publication Date: 2018-11-13
SHENGYUAN PHARMA GUANGZHOU LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, artificial tears are only a substitute for tears and have no therapeutic effect in themselves; long-term use of corticosteroids and CsA and other drugs have certain toxic and side effects on the ocular surface. So far, there is no special effect for the treatment of dry eye in clinical practice. drug

Method used

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  • Ophthalmic drug combination and preparation and application methods thereof
  • Ophthalmic drug combination and preparation and application methods thereof
  • Ophthalmic drug combination and preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0035] 1. Prescription

[0036] sodium hyaluronate

1.0g

Ethylparaben

0.3g

Sodium chloride

5.0g

Glycine dipeptide

10.0g

Add water for injection to

1000mL

NaOH

0.25mol / L, adjust the pH value to 7.0

[0037] 2. Preparation method:

[0038] Weigh sodium chloride and ethylparaben and add 800mL of water for injection (85°C) and stir to dissolve. After dissolving, add sodium hyaluronate under stirring, and keep stirring until dissolved, then add dipeptide, stir to dissolve, and add water for injection to 1000mL, add sodium hydroxide to adjust the pH value to 7.0, boil and sterilize at 100°C for 30min, filter through a 0.22μm microporous membrane, and dispense into sterilized eye drops bottles under aseptic conditions, 5ml / piece.

preparation example 2

[0040] 1. Prescription

[0041] sodium hyaluronate

[0042] 2, the preparation method is the same as that of Preparation Example 1

preparation example 3

[0044] 1. Prescription

[0045] sodium hyaluronate

[0046] 2, the preparation method is the same as that of Preparation Example 1

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Abstract

The invention relates to an ophthalmic drug combination and preparation and application methods thereof. The ophthalmic drug combination comprises N-(2)-L-alanyl-L-glutamine which is suspended or dissolved inside eye-acceptable isotonic solution. The ophthalmic drug combination is low in irritation, good in stability and high in safety.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an ophthalmic pharmaceutical composition, a preparation method thereof, and an application thereof in preparation of ophthalmic preparations for alleviating and / or improving dry eye symptoms and / or treating dry eye. Background technique [0002] Dry eye refers to a group of diseases that cause tear film instability, ocular discomfort and visual disturbance due to abnormal tears or ocular surface, and has potential damage to the ocular surface, which usually manifests as dryness, foreign body sensation, pain, burning Long-term eye discomfort seriously affects the quality of life of patients. Severe dry eye can also cause keratitis, corneal neovascularization, corneal ulcer and even damage vision. blind. At present, dry eye has become the most common ocular surface disease worldwide. Epidemiological surveys show that the incidence of dry eye in the world is ab...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/08A61K38/05A61K47/02A61P27/02
CPCA61K38/05A61K47/02A61K9/0048A61K9/08A61K9/10A61K47/10A61K47/26A61K47/14A61K47/186A61K47/38A61K47/36A61P27/02A61P27/04
Inventor 刘祖国赵玉芬张晓博黄彩虹吴漾唐果刘艳许鹏翔
Owner SHENGYUAN PHARMA GUANGZHOU LTD
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