Compound amino acid dipeptide injection and preparation method and application thereof

Abstract

The invention belongs to the field of medicine, and provides a compound amino acid dipeptide injection, a preparation method thereof and an application thereof, the injection comprises three cavity bags, the three cavity bags are respectively separated by three bags and filled with a branched-chain amino acid solution, a L-alanyl-L-glutamine solution, and a mixed solution containing arginine hydrochloride and vitamin B6; wherein, in every 1000 mL of the injection solution, the total mass of the amino acid is 50 g to 130 g; and the branched chain amino acid mass accounts for 10 to 80% of the total mass of the amino acid; the mass of L-alanyl-L-glutamine is 5 to 70% of the total mass of the amino acid; the mass of arginine hydrochloride is 0 to 50% of the total mass of the amino acid; and the mass of the vitamin B6 is 0 to 1 g. The injection of the invention improves the stability and effectiveness of the product while providing product safety, and the technical scheme is simple and convenient for industrial production.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound amino acid dipeptide injection and its preparation method and application. Background technique [0002] Amino acid is the basic unit of protein molecules in organisms. It is closely related to the life activities of organisms. It is one of the essential nutrients in organisms. The digestion and absorption of protein in the body is completed through amino acids. The need for amino acids is actually the need for amino acids. Hypoproteinemia is the result of negative nitrogen balance caused by various reasons. The main causes are: insufficient protein intake or malabsorption, loss of appetite and anorexia caused by various reasons; Hepatic protein synthesis ability is reduced, plasma protein synthesis is reduced, a large amount of protein is lost for a long time; protein decomposition is accelerated, etc. A variety of amino acids (including dipeptides, etc.) are pr...

AI Technical Summary

Problems solved by technology

However, amino acid injections currently available on the market are not aimed at such perioperative anesthesia patients (preoperative, intraoperative, and early postoperative) and cannot meet the needs of such patients for material and energy metabolism.

In the prior art, there is a lack of technical solutions for infusion of compound amino acid injection during perioperative anesthesia, and the infusion of energy substances (amino acids, fats) other than glucose is considered when the patient is still unable to eat effectively 7-10 days after the operation. , which may miss the best opportunity to improve the body's material and energy metabolism, enhance the body's immunity, and promote the body's wound healing

[0004] In addition, in clinical use, mixing multiple components together to prepare injections often requires the addition of a large amount of additives to maintain the stability of the injection, but the addition of additives may cause adverse reactions

Most of the amino acid injections currently on the market contain antioxidants such as sodium bisulfite, sodium metabisulfite, etc. Although the existence of sulfite solves the problem that amino acids are easily oxidized, it can also cause common side effects, such as bronchial Convulsions, dyspnea, malignant laryngeal edema, hypotension, shock, etc.

Images