Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Modeling method for animal model of type 2 diabetes mellitus

A type 2 diabetes and animal model technology, which is applied in animal husbandry and other fields, can solve the problems of less than 5% mold forming rate, serious individual obesity, and high feeding costs, and achieve the effects of reduced feeding costs, increased commercial value, and long-term maintenance

Inactive Publication Date: 2018-11-16
广州脉缔欣谱医药科技有限公司
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the existing diabetic monkey model is completely induced by a high-sugar and high-fat diet, and the type 2 diabetic monkey model is constructed by the high-sugar and high-fat induction method. The cycle is as long as 2 to 4 years, and the modeling rate is less than 5%. The natural incidence of diabetes in monkeys is quite similar, and often before the diabetes model is formed, the side effects such as excessive obesity and greatly shortened life span have already appeared, and the long-term model building process is extremely expensive to raise

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Modeling method for animal model of type 2 diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A modeling method of an animal model of type 2 diabetes is induced by applying 20 lumens of white light fluorescent lamp and 8 hours of light every day during sleep at night; the induction is continuous for 6 months.

[0016] Embodiment 1 selects normal healthy monkeys, male or female, aged 5-23 years old, under normal feeding conditions, annual cycle and circadian rhythm of the Tropic of Cancer, temperature 18-30 degrees Celsius, humidity is not limited, two meals of standard monkey food per day, one Eat fruit, and ensure that members of all levels in the monkey group have enough time to eat, distilled drinking water around the clock, and other living conditions are raised according to routine.

[0017] The modeling method of Example 1 has a short molding cycle, no obesity and other complications, the death rate due to diabetes during the modeling process is less than 1%, and the success rate of modeling is ≥ 12.0%.

Embodiment 2

[0019] A modeling method of an animal model of type 2 diabetes is induced by applying 100 lumens of blue light and 10 hours of light every day during sleep at night; continuous induction for 2 months.

[0020] Example 2 selects normal healthy monkeys, male or female, aged 5-23 years old, under normal feeding conditions, annual cycle and circadian rhythm of the Tropic of Cancer, 18-30 degrees Celsius, unlimited humidity, two meals a day of standard monkey food, one meal Fruits, and to ensure that members of all levels in the monkey group have enough time to eat, distilled drinking water around the clock, and other living conditions are kept according to conventional feeding.

[0021] The modeling method of Example 2 has a short molding cycle, no obesity and other complications, the death rate due to diabetes during the modeling process is less than 1%, and the success rate of modeling is ≥ 47.0%.

Embodiment 3

[0023] A modeling method of an animal model of type 2 diabetes is induced by applying 50 lumens of white light fluorescent lamp and 9 hours of light every day during sleep at night; continuous induction for 4 months.

[0024] Example 3 selects normal healthy monkeys, male or female, aged 5-23 years old, under normal feeding conditions, annual cycle and circadian rhythm of the Tropic of Cancer, 18-30 degrees Celsius, unlimited humidity, two meals a day of standard monkey food, one meal Fruits, and to ensure that members of all levels in the monkey group have enough time to eat, distilled drinking water around the clock, and other living conditions are kept according to conventional feeding.

[0025] The modeling method of Example 3 has a short molding cycle, no obesity and other complications, the death rate due to diabetes in the modeling process is less than 1%, and the success rate of modeling is ≥ 23.5%.

[0026] In addition, the modeling method of the present invention (ta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of animal models of diabetes mellitus, and particularly relates to a modeling method for an animal model of type 2 diabetes mellitus. The method comprisesthe step that 20-100 lumens and 8-10 hours of illumination is applied during nighttime animal sleep for induction, wherein the induction time is 2-6 month. The method provided by the invention fills the blank of modeling of the animal model of the type 2 diabetes mellitus by a natural induction method, shortens the modeling time of the animal model, and has fewer side effects; and the problems such as too serious obesity and too high mortality of individuals do not easily occur, and feeding costs are greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of diabetic animal models, and in particular relates to a modeling method for type 2 diabetic animal models. Background technique [0002] At present, the existing type 2 diabetes models mainly include diabetic rats, diabetic mice, and diabetic monkeys. Among them, the rat and mouse type 2 diabetes models mainly include the model caused by genetic factors and the model induced by high-sugar and high-fat diet. However, because the circadian rhythm, individual size, lifespan, and the role of glucose metabolism hormones in rats and mice are quite different from those of humans, the data obtained from this type 2 diabetes model are not suitable for humans. Monkeys and humans belong to primates, and they have a high degree of similarity in genetics, biological rhythms, anatomical structures, physiological and biochemical indicators, etc. The type 2 diabetes model constructed with monkeys as the object of action ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 王树兴
Owner 广州脉缔欣谱医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com