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Application of malus toringoides and malus transitoria fruits and extracts thereof in preparation of antihypertensive drugs

A kind of technology of extract and russet fruit, which is applied in the field of use in preparing antihypertensive drugs

Pending Publication Date: 2018-11-16
SICHUAN ZHIJIACHENG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there is no relevant report on the effective part of russa fruit for the treatment of antihypertensive effect

Method used

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  • Application of malus toringoides and malus transitoria fruits and extracts thereof in preparation of antihypertensive drugs
  • Application of malus toringoides and malus transitoria fruits and extracts thereof in preparation of antihypertensive drugs
  • Application of malus toringoides and malus transitoria fruits and extracts thereof in preparation of antihypertensive drugs

Examples

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Embodiment 1

[0015] Example 1 Preparation of various solvent extraction parts of "Russeguo" of the present invention

[0016] Take 100g of Eseguo powder through a No. 2 sieve, add 2000mL 95% ethanol to reflux and extract twice according to the ratio of solid to liquid of 1:20, each time for 2h, filter while hot, add 10 times the amount of water to the residue and decoct twice , 2 hours each time, filtered while hot; combined 2 times of alcohol extraction filtrates, and recovered ethanol under reduced pressure to no alcohol smell; combined 2 times of water extraction filtrates and concentrated to obtain extractum, which was the total extraction part after vacuum drying of the extractum (total extract It is a mixed extract of alcohol extraction and water extraction). Disperse the extract with water extract concentrate to make it fully and evenly dissolve, then add petroleum ether, dichloromethane, ethyl acetate, and water-saturated n-butanol for extraction, each time 300mL, and extract conti...

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Abstract

The invention provides application of malus toringoides and malus transitoria fruits and extracts thereof in preparation of antihypertensive drugs. The invention for the first time studies the influence of different extraction parts (total extraction part, aqueous extraction part, n-butyl alcohol extraction part, dichloromethane extraction part and petroleum ether extraction part) in malus toringoides and malus transitoria fruits on isolated thoracic aorta ring vascular ring tension of rats, and performs comparison with malus toringoides and malus transitoria fruits. The result indicates thatthe same extraction parts of malus toringoides and malus transitoria fruits have no significant influence on basic state vascular rings and have different degrees of relaxation effects on potassium chloride pre-constricted vascular rings, and among all the extraction parts, the n-butyl alcohol part, the ethyl acetate part and dichloromethane part have strong relaxation effects.

Description

technical field [0001] The present invention relates to the new application of russa fruit. Specifically, it is the application in the preparation of antihypertensive drugs. Background technique [0002] The invention relates to the dried and mature fruit of Rosaceae plants Malus toringoides (Rehd.) Hughes. and Malus transitoria (Batal.) Schneid. In the Tibetan area of ​​Ganzi, Russian fruit is commonly known as Waduo, Hongwaduo, Baiwaduo, etc. In addition, it is also called Dabaishizao, Xiaobaishizao, Astringent Zaozi, etc. in Gansu, and Huaye Duli (northern Shaanxi) Alias, such as madur pear, thin and weak crabapple. It is recorded in "Xinxiu Jingzhu Materia Medica", "Zhonghua Tibetan Materia Medica" and "Tibetan-Chinese Dictionary". "Etc. Eseguo has a long history of medicinal use in Tibetan areas, but there are few studies on its modern pharmacological effects. It has been reported in the literature that Eseguo has a certain protective effect on alcohol-induced acute...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P9/12A61K131/00
CPCA61K36/73A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P9/12
Inventor 何刚
Owner SICHUAN ZHIJIACHENG BIO TECH CO LTD
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