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Aorta blood pressure controlled release medicine carrying support and blood pressure control medicine release system

An aortic and drug-loaded technology, applied in stents, drug devices, and vascular assessment, can solve problems affecting the treatment effect of aortic dissection cavity, non-invasive monitoring of aortic blood pressure, and local fragility

Active Publication Date: 2018-12-21
SHANGHAI CHANGHAI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the occurrence of adverse events may seriously affect the therapeutic effect and prognosis of aortic dissection, such as the mismatch between the graft and the vessel wall, resulting in incomplete closure of the gap, abnormalities in the systemic or local blood system, or special dynamic characteristics ( Under the impact of blood flow (such as blood pressure fluctuations), the false lumen cannot be completely thrombosed (even without thrombus), and then may occur: 1) The blood flow of the true lumen cannot be restored, and the false lumen undergoes progressive tumor-like expansion; 2) The false lumen Blood supply from the distal rupture, new retrograde tearing dissection; 3) special form of false lumen thrombosis can lead to differences in the mechanical strength of the vessel wall, local fragile areas, etc.
[0004] Due to the inability to non-invasively monitor the patient's aortic blood pressure, it is difficult to evaluate the prognosis and risk of complications of endovascular exclusion of aortic dissection; at the same time, there is a lack of preventive and precise treatment of local fragile vessel walls in patients with hypertension means

Method used

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  • Aorta blood pressure controlled release medicine carrying support and blood pressure control medicine release system
  • Aorta blood pressure controlled release medicine carrying support and blood pressure control medicine release system
  • Aorta blood pressure controlled release medicine carrying support and blood pressure control medicine release system

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Effect test

Embodiment 1

[0032] This embodiment provides a drug-loaded stent for controlled release of aortic blood pressure, such as Figure 1 to Figure 6 As shown, the aortic blood pressure controlled-release drug-loaded stent includes a stent body 10 , a conductive drug-loaded coating 20 , a piezoresistor 12 and a power source 11 . The conductive drug-loaded film 20 is coated on the outer surface of the stent main body 10 . The piezoresistor 12 is connected with the power supply 11 to form a loop. When the pressure on the piezoresistor 12 is greater than the threshold value, the resistance decreases, and there is a microcurrent in the loop. The conductive drug-loaded coating 20 conducts the microcurrent in the loop to the body. surface. The maximum micro current in the loop is less than 10mA.

[0033] Among them, such as Figure 5 As shown, the stent body 10 can be made of nickel-titanium alloy wire, and the nickel-titanium alloy has shape memory properties, and can automatically restore its own...

Embodiment 2

[0045] An embodiment of the present invention also provides an aortic blood pressure monitoring system, including a monitoring device and a drug-loaded stent for controlled release of aortic blood pressure. The aortic blood pressure controlled-release drug-loaded stent can be placed in the blood vessel using the aortic blood pressure controlled-release drug-loaded stent provided in the first embodiment above. The monitoring device is used to connect to the body surface to detect the potential signal of the body surface.

[0046] Specifically, similar to an electrocardiograph, the monitoring device may include a plurality of contact electrodes connected to the body surface, and a host computer connected to the contact electrodes through lead wires or wirelessly to detect body surface potential.

[0047] When the pressure on the piezoresistor in the aortic blood pressure controlled-release drug-loaded stent is greater than the threshold, the resistance of the piezoresistor is gr...

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PUM

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Abstract

The invention provides an aorta blood pressure controlled release medicine carrying support and a blood pressure control medicine release system, and belongs to the technical field of endovascology. The aorta blood pressure controlled release medicine carrying support comprises a support body, a lining laminating film, a conductive medicine carrying laminating film, a pressure sensitive resistor and a power source; the lining laminating film wraps the inner surface of the support body, and the conductive medicine carrying laminating film wraps the outer surface of the support body; the power source, the pressure sensitive resistor and the support body are connected to form a loop, when pressure borne by the pressure sensitive resistor is larger than a threshold value, the resistance is lowered, micro current exists in the loop, and medicine release is promoted through the conductive medicine carrying laminating film, and micro current can be transmitted to the body surface. The aorta blood pressure controlled release medicine carrying support can perform non-invasive monitoring on aorta blood pressure of a patient, evaluation is performed on the treatment effect of the aorta interlayer, risk early warning is performed, and meanwhile preventive accurate medicine treatment can be performed on the local lesion.

Description

technical field [0001] The invention relates to the technical field of aortic blood pressure monitoring, in particular to an aortic blood pressure controlled release drug-loaded stent and a blood pressure controlled drug release system. Background technique [0002] Aortic dissection refers to aortic disease in which arterial blood enters the aortic wall through a breach in the aortic intima, causing the aortic media to separate from the aortic adventitia, resulting in a false lumen. At present, the treatment of aortic dissection can use aortic stents to reshape the aorta and at the same time block or partially block the blood flow of the false lumen, thus playing the role of treating aortic dissection. [0003] However, the occurrence of adverse events may seriously affect the therapeutic effect and prognosis of aortic dissection, such as the mismatch between the graft and the vessel wall, resulting in incomplete closure of the gap, abnormalities in the systemic or local bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61M31/00A61B5/021
CPCA61M31/00A61B5/021A61F2/90
Inventor 李逸明景在平张磊周建
Owner SHANGHAI CHANGHAI HOSPITAL
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