Perylene dye fluorescent carbon dot as well as preparation method and application thereof

A technology of fluorescent carbon dots and dyes, applied in the field of antibacterial materials, can solve problems such as increasing antibacterial effect, etc., and achieve the effects of low risk, simple reaction steps and mild reaction conditions

Inactive Publication Date: 2018-12-21
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 3,4,9,10-perylenetetracarboxylic dianhydride, as a raw material for the synthesis of fluorescent carbon dots, and the photodynamic force that can be produced by the perylene dye fluorescent carbon dots synthesized by the common hydrothermal reaction of highly water-soluble PEI can be effective To increase the antibacterial effect, there is still no report

Method used

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  • Perylene dye fluorescent carbon dot as well as preparation method and application thereof
  • Perylene dye fluorescent carbon dot as well as preparation method and application thereof
  • Perylene dye fluorescent carbon dot as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of perylene dye fluorescent carbon dot 1:

[0032] 1) Weigh 1.2g of PEI (Mn=550~650), and weigh 60mg of 3,4,9,10-perylenetetracarboxylic dianhydride, put them into a centrifuge tube together with 30mL of secondary water and ultrasonicate for 30min, then add together Into the hydrothermal reaction kettle, react at 200°C for 10h;

[0033] 2) After the reaction is completed, cool down to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.45 μm pinhole filter, and the obtained filtrate is perylene dye fluorescent carbon dots.

Embodiment 2

[0035] Preparation of perylene dye fluorescent carbon dots 2:

[0036] 1) Weigh 1.2g of PEI (Mn=550~650), and weigh 60mg of 3,4,9,10-perylenetetracarboxylic dianhydride, put them into a centrifuge tube together with 30mL of secondary water and ultrasonicate for 30min, then add together Into the hydrothermal reaction kettle to the hydrothermal reaction kettle, react at 200°C for 8h;

[0037] 2) After the reaction is completed, cool down to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.45 μm pinhole filter, and the obtained filtrate is perylene dye fluorescent carbon dots.

Embodiment 3

[0039] Preparation of perylene dye fluorescent carbon dots 3:

[0040] 1) Weigh 1.2g of PEI (Mn=550~650), and weigh 60mg of 3,4,9,10-perylenetetracarboxylic dianhydride, put them into a centrifuge tube together with 30mL of secondary water and ultrasonicate for 30min, then add together Into the hydrothermal reaction kettle, react at 180°C for 10h;

[0041] 2) After the reaction is completed, cool down to room temperature, and perform dialysis with a 1000D dialysis bag for 3 days, and then filter the dialysis product with a 0.45 μm pinhole filter, and the obtained filtrate is perylene dye fluorescent carbon dots.

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Abstract

The invention discloses a perylene dye fluorescent carbon dot as well as a preparation method and application thereof. The perylene dye fluorescent carbon dot is prepared through hydrothermal reactionof polyethyleneimine and 3,4,9,10-perylenetetracarboxylic dianhydride in deionized water. The prepared perylene dye fluorescent carbon dot has better water solubility and can be used as a photosensitizer, and photodynamic role produced by the photosensitizer can sterilize bacteria effectively, especially staphylococcus aureus and methicillin-resistant staphylococcus aureus. The preparation methodhas the advantages of simple reaction steps, mild reaction conditions, low risk and low toxicity and the like.

Description

technical field [0001] The invention belongs to the field of antibacterial materials, and relates to a perylene dye fluorescent carbon dot and a preparation method and application thereof. Background technique [0002] In recent years, due to the abuse of antibiotics has led to the emergence and spread of "super bacteria". The so-called "super bacteria" means that these bacteria have multi-drug resistance to current antibiotics, which adds great difficulty to the treatment of clinical wound infections. Therefore, the development of new anti-infection strategies is imminent. Photodynamic antimicrobial therapy is one of the most promising new therapies, which has shown good curative effect on infections caused by bacteria, fungi and viruses, especially for drug-resistant bacterial infections. [0003] 3,4,9,10-Perylenetetracarboxylic dianhydride, bright red uniform powder, blue light red shade, also known as perylene red Y, C.I. pigment 224, etc. As an intermediate for the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09B69/10C09K11/06A61K41/00A61P31/04
CPCA61K41/0057A61P31/04C09B69/102C09K11/06C09K2211/1466
Inventor 徐立群王浩哲宁玲贵郝杰程艳芳
Owner SOUTHWEST UNIV
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