A method for simultaneous determination of three fat-soluble vitamins in multivitamin injection
A technology for fat-soluble vitamins and vitamins, applied in the field of analytical chemistry, can solve the problems of cumbersome and time-consuming sample processing, gradient elution, and complex mobile phases
Active Publication Date: 2021-08-20
河北远征药业有限公司
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Problems solved by technology
[0004] The technical problem to be solved by the present invention is to provide a method for simultaneously measuring the contents of three fat-soluble vitamins in multivitamin injections. The problem of tedious and time-consuming sample processing
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[0024] The technical solutions in the embodiments of the present invention are clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0025] In the following description, a lot of specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described here, and those skilled in the art can do it without departing from the meaning of the present invention. By analogy, the present invention is therefore not limited to the specific examples disclosed below.
[0026] This embodiment ...
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Abstract
The invention discloses a method for simultaneously determining the contents of three fat-soluble vitamins in multivitamin injections, and relates to the field of analytical chemistry. The invention comprises the following steps: filling octadecylsilane bonded silica gel into a chromatographic column of a liquid chromatograph as a stationary phase; preparing methanol-acetonitrile-ethyl acetate as a mobile phase; accurately weighing vitamin A and vitamin D 3 Take an appropriate amount of vitamin E reference substance, add isopropanol to dilute to make a contrast solution; accurately measure the multivitamin injection to be tested, dilute it with isopropanol, and prepare a test solution; take the reference substance solution and the test solution respectively Sample solution, inject liquid chromatograph and carry out isocratic elution, record chromatogram; Calculate the concentration of need testing solution by peak area by external standard method. The invention solves the problems in the prior art that three different detection wavelengths are used, gradient elution, complicated mobile phase, and tedious and time-consuming sample processing process.
Description
technical field [0001] The invention relates to the field of analytical chemistry, in particular to a method for simultaneously determining the contents of three fat-soluble vitamins in multivitamin injections. Background technique [0002] Vitamins are a class of organic compounds necessary to maintain human health, promote growth and development, and regulate physiological functions. With the development of society, more and more multivitamin products have appeared on the market. Then, the determination method of vitamin in the product is particularly important. [0003] vitamin A, vitamin D 3 Vitamin E and vitamin E are fat-soluble vitamins, which are easy to accumulate in the body. Excessive intake will lead to poisoning. This requires a rapid detection method for fat-soluble vitamins. Now, high-performance liquid chromatography is more commonly used. The detection of vitamins A, D, and E in food, dairy products, serum, and injections has been reported, but there are ...
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IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 宋婷婷刘毅刘静瞿红颖郭建立魏永辉郭鸿志李红园魏丽娟
Owner 河北远征药业有限公司