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Antiviral traditional Chinese medicine composition and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as large side effects of western medicine, drug dependence, and drug-induced diseases

Active Publication Date: 2021-07-06
史明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many antiviral drugs for the treatment of viruses, but the curative effect is not significant, and it is necessary to take drugs for a long period of time. In many cases, patients have already recovered to a large extent. The side effects are relatively large, and it is easy to cause drug-induced diseases. Over time, the body will become dependent on the drug.

Method used

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  • Antiviral traditional Chinese medicine composition and preparation method thereof
  • Antiviral traditional Chinese medicine composition and preparation method thereof
  • Antiviral traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 50 parts of rhodiola, 10 parts of senna leaf, 50 parts of fangbo leaf, 50 parts of astragalus, 20 parts of Magnolia officinalis and 30 parts of Zexie.

[0023] The preparation method of Chinese medicine composition comprises the following steps:

[0024] Step 1. Stir-fry the above-mentioned senna leaves and arborvitae leaves with 2 times the weight of gravel over fire for 1 hour, separate and remove the gravel, add 5 times the weight of water to distill, collect the distillate, add activated carbon, and boil 5min, remove activated carbon, obtain the first mixture;

[0025] Step 2: Rinse the above-mentioned Zexie in boiling water for 10 seconds, drain, repeat 3 times, soak in an equal weight of 15wt.% citric acid solution for 1 hour, add 5 times the amount of water to decoct, and cool to room temperature, refrigerated at 0-4°C for 24 hours, and filtered to remove the f...

example 2

[0046] Table 2 example 2 in vitro antiviral test

[0047]

[0048] The impact of table 3 example 2 dilution 64 times on virus cytopathic effect (P<0.05)

[0049]

[0050]

[0051] Table 2, 3 result shows: example 2 has obvious inhibitory action to the cytopathic effect of parainfluenza, RSV, influenza type A, type B, HSV-1, HSV-2 virus in vitro, and its IC 50 Respectively 0.38, 0.37, 0.44, 0.29, 0.37, 0.51mg crude drug / mL, TI were 5.8, 5.9, 5.0, 7.6, 5.9, 4.3, for CoxB 4 , CoxB 5 、A 3 、A 7 The virus has a certain inhibitory effect, and the TIs are 2.9, 3.7, 3.3, and 2.9, respectively.

[0052]

[0053]Inhibitory effect on influenza virus pneumonia in rats: get SD rats, SPF grade, 40, half male and half male, randomly divided into 4 groups according to body weight, normal control group, virus infection group, ribavirin group, Example 2 administration group. The ribavirin group and the example 2 administration group were administered by intragastric administrati...

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Abstract

The invention discloses a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 50 parts of Rhodiola rosea, 10 parts of senna leaf, 50 parts of arborvitae leaf, 50 parts of astragalus, 20 parts of magnolia bark and 30 parts of Zexie. The invention also discloses a preparation method and application of the traditional Chinese medicine composition. The invention does not add stabilizers and preservatives, and the prepared product has good anti-virus effects in vitro and anti-virus in vivo, and has great popularization value.

Description

technical field [0001] The present invention relates to the field of medicine. More specifically, the present invention relates to an antiviral traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Viral upper respiratory tract infection (acuteupper Respiratoinginfection) is a common and frequently-occurring disease in children, which can occur throughout the year, and can occur several times per person per year. Pathogens mainly invade the nose, pharynx, tonsils and larynx and cause inflammation. At present, there are many antiviral drugs for the treatment of viruses, but the curative effect is not significant, and it is necessary to take drugs for a long period of time. In many cases, patients have already recovered to a large extent. The side effects of drugs are relatively large, and it is easy to cause drug-induced diseases. Over time, the body will become dependent on the drugs. Contents of the invention [0003] ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61P31/12A61P11/00
CPCA61K36/14A61K36/41A61K36/481A61K36/482A61K36/575A61K36/884A61K2236/13A61K2236/17A61K2236/331A61P11/00A61P31/12A61K2300/00
Inventor 吴伟
Owner 史明
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