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A Hand-washing liquid for inhibiting bacteria of herba Epimedii and a preparation method thereof

A technology of epimedium and hand sanitizer, applied in antibacterial, antifungal, pharmaceutical formulations and other directions, can solve the problems of expensive extraction equipment, strong volatility of extraction solvent, difficult quality control of Epimedium extract, etc. The effect of realizing industrialized large-scale production, weakening adhesion and ensuring the source of raw materials

Pending Publication Date: 2019-01-11
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The used supercritical extraction equipment of this invention is comparatively expensive
On the whole, the existing technologies have their own characteristics, and their characteristics and shortcomings are as follows: (1) most products use various Chinese medicinal materials as plant raw materials, and except Epimedium, other Chinese medicinal materials are also used, but Some Chinese medicinal materials do not belong to the category of medicinal and edible plants, and may have potential toxicity or safety hazards; (2) the prior art does not select the species of Epimedium when selecting Epimedium as a plant raw material
In fact, there are many varieties of Epimedium, many of which do not meet the requirements of the Pharmacopoeia, and its effectiveness and safety are difficult to guarantee
(3) Most of the antibacterial substances in the prior art are epimedium essential oil, icariin or other Chinese medicinal material extracts, which do not involve epimedium alkaloids, nor do they combine epimedium alkaloids with epimedium Combination of water extracts
After the combination of Epimedium alkaloids and water extracts, its antibacterial activity is significantly improved; (4) Some prior art does not require the content of active ingredients in Epimedium extracts, and it is difficult to determine the content of Epimedium extracts. Quality control affects the stability of product quality
(5) The extraction equipment used in some technologies is relatively expensive, or the extraction solvent used is highly volatile and flammable

Method used

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  • A Hand-washing liquid for inhibiting bacteria of herba Epimedii and a preparation method thereof
  • A Hand-washing liquid for inhibiting bacteria of herba Epimedii and a preparation method thereof
  • A Hand-washing liquid for inhibiting bacteria of herba Epimedii and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preferred antibacterial hand sanitizer of Epimedium sinensis in the present invention is made of the following components by weight: 1.25% of Epimedium alkaloids, 1.25% of Epimedium water extract, and sodium fatty alcohol polyoxyethylene ether sulfate 1%, Coconut Fatty Acid Diethanolamide 2.5%, Alkyl Glycosides 0.75%, Coco Dimethyl Betaine 0.45%, Glycerin 1%, Propylene Glycol 1%, Sodium Chloride 1%, Disodium EDTA 0.1%, 0.2% ethyl 4-hydroxybenzoate, and the balance is distilled water.

[0035] The present invention selects Epimedium heartleaf as the plant raw material, the content of total alkaloids in the Epimedium alkaloids used in preparation is ≥85%, and the content of total flavonoids in the commercialized Epimedium water extracts is ≥75% , The content of total alkaloids in Epimedium alkaloids and total flavonoids in Epimedium water extracts were detected by spectrophotometry, and the spectrophotometry was carried out in accordance with the method published in t...

Embodiment 2

[0045] Epimedium heart leaf antibacterial hand sanitizer is made of the following components by weight percentage: Epimedium alkaloids 2%, Epimedium water extract 0.5%, Sodium fatty alcohol polyoxyethylene ether sulfate 0.5%, coconut oil Fatty Acid Diethanolamide 1%, Alkyl Glycoside 0.25%, Coco Dimethyl Betaine 0.3%, Glycerin 1%, Propylene Glycol 1.5%, Sodium Chloride 1%, Disodium EDTA 0.1%, 4- Ethyl hydroxybenzoate 0.2%, the balance is distilled water.

[0046] The preparation method of the Epimedium cordata antibacterial hand lotion in this example is the same as that in Example 1.

Embodiment 3

[0048] Epimedium heart leaf antibacterial hand sanitizer is made from the following components by weight: Epimedium alkaloids 1.5%, Epimedium water extract 1%, Fatty alcohol polyoxyethylene ether sodium sulfate 2%, Coconut oil Fatty Acid Diethanolamide 2%, Alkyl Glycoside 0.5%, Coco Dimethyl Betaine 0.75%, Glycerin 1%, Propylene Glycol 1%, Sodium Chloride 1%, Disodium EDTA 0.2%, 4- Ethyl hydroxybenzoate 0.2%, the balance is distilled water.

[0049] The preparation method of the Epimedium cordata antibacterial hand lotion in this example is the same as that in Example 1.

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Abstract

A Hand-washing liquid for inhibit bacteria of herba Epimedii is prepared from the following components by weight percentage: 0.5 to 5 percent of epimedium alkaloid, 0.5 to 4 percent of epimedium wat extract, 0.5 to 2 percent of fatty alcohol polyoxyethylene ether sodium sulfate, 1-3 percent of coconut oil fatty acid diethanolamide, 0. 25-1 percent of alkyl glycoside, 0. 3-0.75 percent of coconut oil-based dimethyl betaine, 0. 5-2 percent of glycerol, 0. 5-3 percent of propylene glycol, 0. 5-4 percent of sodium chloride, 0. 05-0.3 percent of ethylene diamine tetraacetic acid disodium, and 4. 5-0.3 percent of glycerol. 0.05 to 0.4 percent of ethyl hydroxybenzoate and that balance of distil water; the inventional also discloses a preparation method of the hand washing liquid, wherein an ultrasonic wave is used for preparing the hand washing liquid; Epimedium alkaloids were prepared by microwave synergistic extraction. The hand-washing liquid had no obvious irritation to skin and no allergic reaction. The quality indexes of the hand-washing liquid were in accordance with the national standard, and some performance indexes were better than those of the same kind of products sold in themarket, which had high efficiency and broad-spectrum bacteriostasis. The preparation method is advanced, the extraction rate of the effective ingredient is high, and the automatic and large-scale production can be realized.

Description

technical field [0001] The invention belongs to the technical field of hand soap and preparation thereof, and in particular relates to an antibacterial hand soap of Epimedium cordata and a preparation method thereof. Background technique [0002] Pathogens are one of the most common pathogenic agents. Among the parts of the human body, hands have the most contact with the outside world and are very susceptible to contamination by various pathogenic bacteria. Washing your hands with hand sanitizer, soap, or soap can help reduce pathogen contamination on your hands. Because of its convenience and hygiene, hand sanitizer has partially replaced soap and soap and become an important hand cleaner. At present, there are two main types of hand sanitizers on the market: one is an ordinary hand sanitizer with the ability to "clean and decontaminate" and the "Wei Zhuang Zhunzi"; The word "hand sanitizer." The latter belongs to the category of disinfection products, which can help k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/10A61Q17/00A61P31/04A61P31/02A61P31/10
CPCA61K2800/81A61K2800/82A61Q17/005A61Q19/10A61K8/9789A61P31/02A61P31/04A61P31/10
Inventor 张华峰李璐黄盈盈
Owner SHAANXI NORMAL UNIV
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