Preloaded biological heart valve capable of rapidly rehydrating and preparation method thereof
A heart valve, pre-installed technology, applied in the field of medical materials and medical devices, can solve the problems of inconvenient use, inability to achieve rehydration, and inability to spread folds, and achieve the effect of convenient use
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0042] The specific implementation steps are as follows: 1) After cleaning the porcine pericardial valve with deionized water, soak it for 2 days at 4°C in an aqueous solution of 50% polyglutamic acid and 1% condensing agent; 2. ) at 4°C for 7 days in a 5% glutaraldehyde solution; 3) at 4°C for 2 days in a 50% α-amino polyethylene glycol aqueous solution; 4) with After washing with deionized water, dry at 37°C for 1 day to obtain the target prefabricated biological heart valve material.
[0043] It was found through testing that the dry artificial biological heart valve prepared in this embodiment can achieve rapid rehydration, and the creases can be quickly flattened after rehydration. At the same time, it can still maintain good flexibility in a dry state and has excellent mechanical properties and biocompatibility.
Embodiment 2
[0045] The specific implementation steps are as follows: 1) After the bovine pericardial valve is cleaned with deionized water, soak it for 2 days at 4°C in an aqueous solution of 50% polyglutamic acid and 5% condensing agent; 2. ) at 4°C for 7 days in a 5% glutaraldehyde solution; 3) at 4°C for 2 days in a 50% α-amino polyethylene glycol aqueous solution; 4) with After washing with deionized water, dry at 37°C for 3 days to obtain the target preinstallable biological heart valve material.
[0046] It was found through testing that the dry artificial biological heart valve prepared in this embodiment can achieve rapid rehydration, and the creases can be quickly flattened after rehydration. At the same time, it can still maintain good flexibility in a dry state and has excellent mechanical properties and biocompatibility.
Embodiment 3
[0048] The specific implementation steps are as follows: 1) After cleaning the porcine pericardial valve with deionized water, soak it in a glutaraldehyde solution with a concentration of 5% at 4°C for 7 days; % polyglutamic acid and a concentration of 5% condensing agent in an aqueous solution soaked for 5 days; 3) at 4 ° C, soaked in a concentration of 50% α-amino polyethylene glycol aqueous solution for 5 days; 4) with After being washed with deionized water, it was dried at 37°C for 5 days to obtain the target prefabricated biological heart valve material.
[0049] It was found through testing that the dry artificial biological heart valve prepared in this embodiment can achieve rapid rehydration, and the creases can be quickly flattened after rehydration. At the same time, it can still maintain good flexibility in a dry state and has excellent mechanical properties and biocompatibility.
PUM
Login to view more Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap