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Fine and uniform methyl vinyl ether-maleic acid inorganic salt copolymers and their use in oral care and pharmaceutical applications

A technology of maleic acid copolymer and methyl vinyl ether, which is used in pharmaceutical science, pharmaceutical formulations, dental preparations, etc., can solve the problems of not providing particle size and its uniformity, and achieve enhanced stability and aesthetics. , Enhanced strength and durability, Slippery consistency effect

Inactive Publication Date: 2019-01-11
BOAI NKY MEDICAL HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. Patent Application No. 2002 / 0111394 is silent on particle uniformity and its effect on final formulation properties and does not provide the teachings disclosed herein to achieve a specific particle size and its uniformity

Method used

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  • Fine and uniform methyl vinyl ether-maleic acid inorganic salt copolymers and their use in oral care and pharmaceutical applications
  • Fine and uniform methyl vinyl ether-maleic acid inorganic salt copolymers and their use in oral care and pharmaceutical applications
  • Fine and uniform methyl vinyl ether-maleic acid inorganic salt copolymers and their use in oral care and pharmaceutical applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 : Effect of Particle Size on Hydration Rate and Adhesion Value

[0052] A batch of methyl vinyl ether-maleic acid partial calcium / sodium mixed salt (PVM / MA-Ca / Na) was prepared using polymerization techniques well known in the art. The resulting viscous solution was dried and the powder was ground in a conventional impact mill. The resulting fine powder is then classified into five particle size states by screening techniques. Table 1 below gives an overview of the particle size fractions obtained.

[0053] Table 1

[0054] Particle Size PVM / MA-Ca / Na Part 1

<15microns

Particle Size PVM / MA-Ca / Na Part 2

15–25microns

Particle Size PVM / MA-Ca / Na Part 3

25–55microns

Particle Size PVM / MA-Ca / Na Part 4

55–105 microns

Particle Size PVM / MA-Ca / Na Part 5

105–300microns

[0055] 1 gram of each of the above PVM / MA-Ca / Na fractions was quickly dispersed in 4 g of distilled water and placed between two polymethyl...

Embodiment 2

[0062] Example 2 : comparative study of the present invention and existing commercial products

[0063] Large batches of PVM / MA-Ca / Na copolymers were produced, dried, and jet-milled to give the fine particle sizes listed for this invention. Combining this material with commercial PVM / MA-Ca / Na copolymer MS-955 (manufactured by Ashland Inc. and used as a base ingredient in many press-adhesive formulations).

[0064] Particle size measurements were taken on both powders using a Malvern Mastersizer 3000 particle size analyzer. figure 2 and 3 The obtained PVM / MA-Ca / Na of the present invention and Particle size curve of MS-955. Table 3 below is a summary of the particle size values ​​for the two polymeric materials.

[0065] table 3

[0066]

[0067] 1) The largest particle size below which it is present in 10% of the sample volume

[0068] 2) The largest particle size below which it is present in 50% of the sample volume, also known as the median particle size by vol...

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Abstract

The invention relates to fine and uniform copolymer powders of partial mixed metal salts of lower alkyl vinyl ether-maleic acid copolymers having a defined particle size distribution. In particular; it relates to powders that are suitably used in the areas of oral care and pharmaceuticals and to methods for preparing the powders. Provided is a composition of powders of partial mixed metal salts oflower alkyl vinyl ether-maleic acid copolymers having : (i) a Dv50 of less than or equal to 25 microns; a Dv90 of less than or equal to 50 microns; and (ii) a particle uniformity reflected by a Dv90 / Dv10 ratio of less than or equal to 10.

Description

technical field [0001] The present invention relates to fine and uniform copolymer powders of partially mixed metal salts of lower alkyl vinyl ether-maleic acid copolymers having a defined particle size distribution. In particular, it relates to powders suitable for use in the field of oral care and pharmaceuticals and methods for the preparation of such powders. Background technique [0002] Inorganic salt derivatives of methyl vinyl ether / maleic acid copolymers have important uses in the field of bioadhesives and mucoadhesives in various oral care and pharmaceutical applications. The use of such polymers as denture adhesives is particularly well documented. [0003] U.S. Patent No. 4,980,391 issued to Kumar et al. and issued to Warner-Lambert Company discloses denture formulations consisting of partially mixed calcium and Sodium salt and sodium carboxymethylcellulose. [0004] U.S. Patent No. 5,298,534 issued to Prosise et al. and issued to ISP Investments Inc. disclose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F30/04C08F22/06C08F8/44C08F8/12A61K6/083A61K6/097A61L15/12C08L29/10C08L31/06C08L39/06C08L33/02C08L5/04A61K6/898
CPCC08F30/04C08L5/04C08L39/06C08F222/02C08L1/286A61L15/24C08F8/44A61K6/17A61K6/898A61K6/887C08F216/18C08L35/08A61K6/35C08L33/08A61K6/889C08F8/12C08F216/125C08J3/12C08J2335/08C08L33/10
Inventor 赫伯特·威廉·乌尔默王坚强王龙袁国栋孙健新孙旭东
Owner BOAI NKY MEDICAL HLDG LTD
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