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A microvalve device for microfluidic chip and its preparation method and application

A microfluidic chip, microvalve technology, applied in valve devices, laboratory containers, chemical instruments and methods, etc., can solve problems such as lax pressing, achieve not easy to close incomplete, precise control of fluid movement, easy to use. The effect of assembly

Active Publication Date: 2020-07-31
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing deformation-based microvalve realizes the compression and recovery of the flow channel by controlling the application and removal of external force on the outer wall of the flow channel. The flow channel is a single flow channel, so the external force required for its deformation is large, and Lax pressing often occurs

Method used

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  • A microvalve device for microfluidic chip and its preparation method and application
  • A microvalve device for microfluidic chip and its preparation method and application
  • A microvalve device for microfluidic chip and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A microvalve device for a microfluidic chip, such as figure 1 , 2 , 3 and 4, including a cover sheet 1, an elastic material layer 2 and a deformable device layer 5, the elastic material layer 2 is located between the cover sheet 1 and the deformable device layer 5, and the elastic material layer 2 is in the middle of the cover sheet 1 An independent liquid flow channel 3 and a cavity 4 are provided, and the cavity 4 is located on both sides of the liquid flow channel 3, and the elastic material layer 2 can be elastically deformed under the extrusion or pulling of the deformable device layer 5, thereby Control the closing and opening of the liquid passage 3.

[0026] In addition, it also includes two round holes 6 arranged on the surface of the cover sheet 1 , which are respectively connected to the openings at both ends of the liquid passage 3 .

[0027] The deformable device layer 5 is a piezoelectric film 7 connected to an electrical signal generating device 8 .

Embodiment 2

[0029] Such as image 3 As shown, using PDMS material, mix the prepolymer and curing agent at a ratio of 10:1, and pour it into the prepared mold. The heights of the above-mentioned protrusions can be the same or different. The PDMS was degassed and then heated to 85°C to solidify, forming a structure consisting of a longer groove and shorter grooves on both sides. A laser engraving machine is used to engrave two circular holes 6 on a piece of glass, and the relative positions of the centers of the two circular holes 6 correspond to the two endpoints of the linear pattern on the surface of the PDMS.

[0030] Align the round hole on the glass sheet with the two ends of the straight line on the PDMS, and the patterned side of the above PDMS is bonded to the glass sheet to form a straight channel (liquid flow channel 3) and two flow channels that can be used for liquid flow operations. Side airtight cavity 4. Cover the surface of the PDMS chip with a piece of deformable device...

Embodiment 3

[0033] According to the method of Example 1, glue the deformable device 5 (piezoelectric film 7 ) to the PDMS surface, and adjust the piezoelectric film 7 to bend in the direction of the liquid passage 3 in advance to make a normally closed valve structure. When no voltage is applied to the piezoelectric film 7, the piezoelectric film 7 squeezes the flow channel, and the upper and lower surfaces of the liquid-passing flow channel 3 fit together, and the fluid cannot pass through. When the electrical signal generating device 8 is used to apply a potential difference opposite to that of Example 1 to the piezoelectric film 7, the center of the piezoelectric film 7 deforms away from the flow channel, so that the upper and lower surfaces of the flow channel 3 are separated, and the fluid can flow normally at this time.

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Abstract

The invention discloses a micro-valve device for a micro-fluidic chip and a preparation method and an application thereof. The micro-valve device comprises a cover sheet, an elastic material layer anda deformable device layer; the elastic material layer is located between the cover sheet and the deformable device layer, and an independent through-liquid flow channel and cavities are formed between the elastic material layer and the cover sheet; and the cavities are located on the two sides of the through-liquid flow channel, the elastic material layer can be elastically deformed under the extrusion or traction of the deformable device layer, so that the through-liquid flow channel is controlled to be closed and opened. According to the micro-valve device, the micro-valve structure is easyto manufacture, and the manufacturing difficulty of the valve structure in the micro-fluidic chip is greatly reduced; and meanwhile, the opening and closing state of the valve can be accurately changed in real time by adjusting an input signal, so that the fluid movement in the micro-fluidic chip is accurately controlled.

Description

technical field [0001] The invention relates to a microvalve device for a microfluidic chip, a preparation method and application thereof, and belongs to the technical field of microfluidic chips. Background technique [0002] The concept of microfluidic chips emerged at the end of the 20th century, through the design and manufacture of miniaturized chip devices to achieve the purpose of automatic and integrated experimental operations. Microfluidic chip technology uses micromachining technology to process a certain pattern on the surface of the material, and after encapsulation and other steps, it becomes a certain flow channel structure to control the flow of fluid in the chip, thereby completing certain reactions, and finally replaces the conventional The purpose of the experimental platform. Microfluidic chips have been widely used in drug screening, cell culture, immune analysis and other fields. [0003] The control of the flow path and whether the fluid flows in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): F16K99/00B01L3/00
CPCB01L3/502738F16K99/0015F16K99/0048F16K2099/0073
Inventor 涂景乔祎陆祖宏梁福鹏傅继业
Owner SOUTHEAST UNIV
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