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Composition for predicting and curing treating type 2 diabetes mellitus, evaluation method and preparation of composition for predicting and treating type 2 diabetes mellitus

A type 2 diabetes, evaluation method technology, applied in the direction of drug combination, compound screening/testing, preparations for in vivo testing, etc.

Pending Publication Date: 2019-02-22
SHENZHEN YUNHE PHARM TECH PARTNERSHIP LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, what ingredients in pig gall can lower blood sugar and the mechanism through which it lowers blood sugar is still unclear.

Method used

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  • Composition for predicting and curing treating type 2 diabetes mellitus, evaluation method and preparation of composition for predicting and treating type 2 diabetes mellitus
  • Composition for predicting and curing treating type 2 diabetes mellitus, evaluation method and preparation of composition for predicting and treating type 2 diabetes mellitus
  • Composition for predicting and curing treating type 2 diabetes mellitus, evaluation method and preparation of composition for predicting and treating type 2 diabetes mellitus

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Embodiment Construction

[0043] In order to make the object, technical solution and effect of the present invention more clear and definite, the present invention will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0044] A composition for predicting and treating type 2 diabetes provided by the present invention is a compound of porcine bile acids, including hyocholic acid, hyodeoxycholic acid, glycine hyodeoxycholic acid, glycine hyodeoxycholic acid, and taurine hyodeoxycholic acid acid, taurohyodeoxycholic acid.

[0045] Specifically, the present composition may be at least one of hyodeoxycholic acid, hyodeoxycholic acid, glycinehyodeoxycholic acid, glycinehyodeoxycholic acid, taurohyodeoxycholic acid, and taurohyodeoxycholic acid.

[0046] The pig bile acid compound can also be extracted from pig b...

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Abstract

The invention provides a composition for predicting and curing treating type 2 diabetes mellitus, and an evaluation method and a preparation of the composition for predicting and treating type 2 diabetes mellitus. The composition is prepared from hyocholic acid, hyodeoxycholic acid, glycohyocholic acid, glycohyodeoxycholic acid, taurohyocholic acid, taurohyodeoxycholic acid, and a steroidal amidehyocholic acid derivative prepared fromformed byprepared from the hyocholic acid or the hyodeoxycholic acid and amino acids except for glycine and taurine. One of targets for a drug prepared from thecomposition is intestinal epithelial endocrine cells, through drug stimulation, a bile acid membrane receptor TGR5 can be excited, meanwhile, a bile acid nucleus receptor FXR is antagonized, the effects of stimulating the intestinal endocrine cells to secrete GLP1 is achieved jointly, and thus blood sugar is reduced; meanwhile, the content of the composition of a human body is detected, the futurediabetes mellitus risk can be predicted, diabetes mellitus can be screened or early detected, and the curing time is savedprolonged for patients; and the curing effect can also be evaluated by testing the content of the composition after curing.

Description

technical field [0001] The invention belongs to the fields of medicine and biotechnology, and particularly relates to a composition for predicting and treating type 2 diabetes, an evaluation method and a preparation thereof. Background technique [0002] Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia, accompanied by a variety of complications, such as the heart, blood vessels, eyes, kidneys and nerves, etc., will produce a variety of symptoms, such as frequent urination , thirst, hunger, diabetic ketoacidosis and hyperosmolar coma. With the aging of the population and the improvement of the quality of life, the incidence of diabetes is gradually increasing at an alarming rate. In 2000, the total number of people with diabetes in the world was 150 million, and in 2017 it grew to 422 million, and the annual death rate reached 1.6 million. It is estimated that by 2040, the number of people with diabetes worldwide will reach 642 million. ...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K31/575A61P3/10
CPCA61K31/575A61K49/0004A61P3/10
Inventor 贾伟赵爱华郑晓皎陈天璐谢国祥
Owner SHENZHEN YUNHE PHARM TECH PARTNERSHIP LTD
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