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A Dichroic Curved Mirror Structure for Improving the Signal-to-Noise Ratio of a Fluorescence Detector

A fluorescence detector and mirror technology, applied in fluorescence/phosphorescence, instruments, measuring devices, etc., can solve the problem of rarely reflecting excitation light, and achieve the effect of improving the detection signal-to-noise ratio

Active Publication Date: 2021-06-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The reflective mirror only reflects fluorescence (reflectivity greater than 85%), and rarely reflects excitation light (reflectivity less than 5%), while the unreflected excitation light passes through the dichroic spherical mirror to the light absorption box, in the box Fully scatter and absorb, thus solving the problem that fluorescence and stray light of excitation light are reflected together, and improving the signal-to-noise ratio of the detector

Method used

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  • A Dichroic Curved Mirror Structure for Improving the Signal-to-Noise Ratio of a Fluorescence Detector
  • A Dichroic Curved Mirror Structure for Improving the Signal-to-Noise Ratio of a Fluorescence Detector
  • A Dichroic Curved Mirror Structure for Improving the Signal-to-Noise Ratio of a Fluorescence Detector

Examples

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Effect test

Embodiment 1

[0028] The optical system is self-built, and the dichromatic curved mirror structure is set in the laser-induced fluorescence orthogonal detection system. System structure such as figure 2 As shown, it includes a dichroic curved mirror 1 (curved concave lens 3, dichroic film 4), light absorption box 2, laser 5, convex lens 6, capillary 7, optical fiber 8, optical filter 9, and detector 10. The curved surface of the dichroic curved mirror 1 is a spherical surface, the center of which is coincident with the axis of the capillary 7 and the excitation point of the laser, and its concave surface faces the direction of the detector 10 . During operation, the excitation light is emitted from the laser 5 and focused on the capillary 7 through the convex lens 6 . The excitation point on the capillary radiates mixed light to the surroundings simultaneously, including sample fluorescence and laser stray light, wherein the mixed light that deviates from the detection direction shoots to...

Embodiment 2

[0032] The optical system is self-built, and the dichromatic curved mirror structure is set in the laser-induced fluorescence orthogonal detection system. System structure such as image 3As shown, it includes a dichroic curved mirror 1 (curved concave lens 3, dichroic film 4), light absorption box 2, laser 5, convex lens 6, capillary 7, optical fiber 8, filter 9, detector 10, through hole 12 . The curved surface of the dichroic curved mirror 1 is an ellipsoid, and its near mirror focus coincides with the axis of the capillary 7 and the laser excitation point, its concave surface faces the direction of the detector 10, and its far mirror focus coincides with the optical fiber 8 port. During operation, after the laser light is emitted from the laser 5 , it is focused by the convex lens 6 and irradiated on the capillary 7 through the through hole 12 . The excitation point on the capillary radiates mixed light to the surroundings simultaneously, including sample fluorescence an...

Embodiment 3

[0036] Self-built optical system, the dichroic curved mirror structure is set in the laser-induced fluorescence orthogonal detection system, the structure is as follows Figure 4 As shown, it includes a dichroic curved mirror 1 (curved concave lens 3, dichroic film 4), light absorption box 2, laser 5, convex lens 6, capillary 7, filter 9, detector 10, through hole 12, lens 14 . Among them, the curved surface of the dichroic curved mirror 1 is a paraboloid, its focal point coincides with the axis of the capillary 7 and the laser excitation point, and its concave surface faces the direction of the detector 10 . When the system is working, the laser is emitted from the laser 5, focused by the convex lens 6, and irradiated on the capillary 7 through the through hole 12. The excitation point on the capillary radiates mixed light to the surroundings simultaneously, including sample fluorescence and laser stray light, wherein the mixed light that deviates from the detection directio...

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Abstract

The invention provides a dichromatic curved mirror structure for improving the signal-to-noise ratio of a fluorescence detector. The reflector is composed of a concave ball lens coated with a layer of dichromatic film on the concave surface and a light absorption box closely attached behind the lens. The reflective mirror only reflects fluorescence (reflectance greater than 85%), and rarely reflects excitation light (reflectance less than 5%), while the unreflected excitation light passes through the dichroic spherical mirror to the light absorption box, and in the box Sufficient scattering and absorption is carried out, thereby solving the problem that the fluorescence and the stray light of the excitation light are reflected together, and further improving the signal-to-noise ratio of the detector.

Description

technical field [0001] The patent of the present invention relates to a reflection mirror structure for a fluorescence detector, more specifically, to a dichromatic curved surface reflection mirror structure for improving the signal-to-noise ratio of a fluorescence detector. Background technique [0002] Fluorescence detector is a kind of ultra-high sensitive detector, which plays an important role in the detection of ultra-trace molecular level. The sensitivity of the detector is one of the important parameters to measure its performance, the greater the fluorescence collection efficiency of the detector, the greater the sensitivity. In principle, the fluorescence generated by the excitation region irradiated by the excitation light is spatially divergent, and the detector can only collect the fluorescence at a small part of the angle, so the collection efficiency of the fluorescence is very low. In order to improve the collection efficiency of fluorescence, people arrange...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 耿旭辉邹郡关亚风宁海静
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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