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Development and application of fully human or humanized bombesin receptor GRPR monoclonal antibody drug or diagnostic reagents

A technology for monoclonal antibodies and diagnostic reagents, which is applied in the fields of medicine and clinical testing, and can solve the problems that the development of fully human or humanized monoclonal antibodies has not yet been reported.

Inactive Publication Date: 2019-03-05
SHENZHEN TYERCAN BIO-PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the development of fully human or humanized monoclonal antibodies against GRPR receptors has not been reported yet.

Method used

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  • Development and application of fully human or humanized bombesin receptor GRPR monoclonal antibody drug or diagnostic reagents
  • Development and application of fully human or humanized bombesin receptor GRPR monoclonal antibody drug or diagnostic reagents
  • Development and application of fully human or humanized bombesin receptor GRPR monoclonal antibody drug or diagnostic reagents

Examples

Experimental program
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Effect test

specific example

[0066] Camptothecin-carbonyl-Pro-DSer-Nle-DTyr-DSer-mAb

[0067] Camptothecin-carbonyl-Hydroxyproline-mAb

[0068] Camptothecin-thioether-Lys-DSer-DSer-DSer-DSer-DSer-Pro-DSer-Nle-DTyr-DSer-mAb

[0069] Methotrexate-CH2CO-DLys-DTyr-Lys-mAb

[0070] Methotrexate-thioether-mAb

[0071] Thiocolchicine-Thioether-DSer-Nle-DTyr-DSer-mAb

[0072] Thiocolchicine-Carbonyl-Sar-DSer-Nle-DTyr-DSer-mAb

[0073] Oligo(DNA)-S-S-mAb

[0074] More GRPR monoclonal antibodies (mAb) are connected to various bioactive molecules (A) through linkers (linkers) (B) to form more antibody complexes, for example (see below):

[0075] The biologically active molecule A (A-B-mAb) linked to the fully human or humanized GRPR monoclonal antibody can be, but not limited to, any known therapeutic agents or cytotoxic agents. For example, antineoplastic agents such as: Acivicin; Aclarubicin; AcodazoleHydrochloride; Acronine; Adozelesin; Adriamycin; Aldesleukin; Anthramycin; Asparaginase; Asperlin; Azacitidi...

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Abstract

The invention discloses development of fully human or humanized GRPR (gastrin-releasing peptide receptor) monoclonal antibody, and an application of related drugs or diagnostic reagents thereof. The GRMPR is abnormally expressed in some specific tissues or pathological tissues, so that the GRMPR receptor can be used as a drug target. When the GRPR monoclonal antibody is used for developing antibody drugs or clinical diagnosis reagents of corresponding drugs, important clinical application and market development values are achieved. However, development of humanized or fully human monoclonal antibodies targeting the GRPR does not exist at present. The invention discloses the development of the fully human or humanized GRPR monoclonal antibody for the first time, and the antibody is used asa carrier to be coupled with various bioactive molecules (such as chemotherapeutic drugs, radioactive drugs and diagnosis markers), various antibody targeted drugs or antibody diagnostic markers are constructed, and the antibody is used for treatment and diagnosis of related diseases. The antibody has a very important clinical application value for prevention and treatment of the related diseases.

Description

technical field [0001] The invention relates to medicines and diagnostic reagents, and belongs to the fields of medicine and clinical testing. Background technique [0002] With the emergence of new technologies and technologies, monoclonal antibody (monoclonal antibody, mAb) has become a new hot spot in modern drug development (1-4). Monoclonal antibodies are macromolecular proteins with strong specificity, high affinity and good stability. These antibodies can be used for disease treatment, disease diagnosis or health check (5-7). At present, dozens of mAb drugs such as adalimumab have been clinically used in the world, and these drugs are used for anti-tumor therapy, immune rejection of organ transplantation, autoimmune diseases, infectious diseases and other human diseases (1,4,5). In the global biopharmaceutical market, the monoclonal antibody drug market is growing rapidly (1,2), and antibody drugs have great potential in the future global drug market (2,4). The pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28G01N33/577A61K39/395A61P35/00A61P31/00A61P1/16A61P33/06A61P37/06A61P37/02A61P29/00A61P3/00A61P3/10A61P3/04A61P19/06A61P9/12
CPCA61K2039/505C07K16/2869C07K2317/21G01N33/577Y02A50/30
Inventor 孙立春蔡车国朱波
Owner SHENZHEN TYERCAN BIO-PHARM CO LTD
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