Cimetidine sodium chloride injection production method capable of preventing impurities from exceeding standard
A technology of cimetidine sodium chloride and titin sodium chloride, which is applied in the field of medicine, can solve problems such as immature production process conditions, low product qualification rate, and excessive impurities in liquid medicine, so as to prevent the degradation of impurities from exceeding the standard, The effect of ensuring the quality of medicines and improving the qualified rate
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Embodiment 1
[0018] A kind of cimetidine sodium chloride injection production method that prevents impurity from exceeding the standard may further comprise the steps:
[0019] 1) Strong blend:
[0020] a. Add 500L of water for injection to the concentrated preparation tank, open the cooling water valve of the concentrated preparation tank to lower the temperature of the concentrated preparation tank to 60°C;
[0021] b. Turn on the stirring, and the stirring rate is controlled at 64r / min;
[0022] c, drop into 2 kilograms of cimetidine, 9 kilograms of sodium chloride, stir and dissolve for 10-15 minutes;
[0023] d. After confirming that all the raw materials are dissolved, open the liquid outlet valve of the thick dispensing tank and the liquid inlet valve of the dilute dispensing tank, start the circulation pump, and pour the liquid medicine into the dilute dispensing tank;
[0024] e. After all the liquid medicine in the concentrated preparation tank is injected into the thin prepara...
Embodiment 2
[0048] A kind of cimetidine sodium chloride injection production method that prevents impurity from exceeding the standard may further comprise the steps:
[0049] 1) Strong blend:
[0050] a. Add 800L of water for injection to the concentrated preparation tank, open the cooling water valve of the concentrated preparation tank to reduce the temperature of the concentrated preparation tank to 70°C
[0051] b. Turn on the stirring device, and the stirring rate is controlled at 80r / min;
[0052] c, drop into 2 kilograms of cimetidine, 9 kilograms of sodium chloride, stir and dissolve for 10-15 minutes;
[0053] d. After confirming that all the raw materials are dissolved, open the liquid outlet valve of the thick dispensing tank and the liquid inlet valve of the dilute dispensing tank, start the circulation pump, and pour the liquid medicine into the dilute dispensing tank;
[0054] e. After all the liquid medicine in the concentrated preparation tank is injected into the thin ...
Embodiment 3
[0078] A kind of cimetidine sodium chloride injection production method that prevents impurity from exceeding the standard may further comprise the steps:
[0079] 1) Strong blend:
[0080] a. Add 1000L of water for injection to the concentrated preparation tank, open the cooling water valve of the concentrated preparation tank to lower the temperature of the concentrated preparation tank to 80°C;
[0081] b. Turn on the stirring device, and the stirring rate is controlled at 110r / min;
[0082] c, drop into 2 kilograms of cimetidine, 9 kilograms of sodium chloride, stir and dissolve for 10-15 minutes;
[0083] d. After confirming that all the raw materials are dissolved, open the liquid outlet valve of the thick dispensing tank and the liquid inlet valve of the dilute dispensing tank, start the circulation pump, and pour the liquid medicine into the dilute dispensing tank;
[0084] e. After all the liquid medicine in the concentrated preparation tank is injected into the thi...
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