Composition with losartan potassium and gliclazide and preparation method thereof
A kind of technology of losartan potassium and composition, applied in the field of losartan potassium and gliclazide composition and preparation thereof
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Embodiment 1
[0028] A composition of losartan potassium and gliclazide and its preparation method:
[0029] The composition includes: 40g of losartan potassium, 60g of gliclazide, 40g of microcrystalline cellulose, 20g of anhydrous calcium hydrogen phosphate, 60g of precrossified starch, 4g of silicon dioxide, and 2g of magnesium stearate;
[0030] Preparation method: Take 4.8g of precrossed starch and add 55.2g of water to make 60g of precrossed starch slurry with a concentration of 8% as a binder, add 40g of losartan potassium, 40g of microcrystalline cellulose, 55.2g of precrossed starch In the mixture composed of starch, make soft material and then granulate with 20-mesh sieve, dry at 40°C until the water content is 1%, and then granulate with 30-mesh sieve, then mix with 40g gliclazide, 20g anhydrous calcium hydrogen phosphate, 4g Silicon dioxide and 2 g of magnesium stearate were uniformly mixed together and then pressed into tablets to obtain losartan potassium and gliclazide compos...
Embodiment 2
[0032] A composition of losartan potassium and gliclazide and its preparation method:
[0033] The composition includes: 60g of losartan potassium, 80g of gliclazide, 60g of microcrystalline cellulose, 40g of anhydrous calcium hydrogen phosphate, 80g of precrossified starch, 8g of silicon dioxide, and 3g of magnesium stearate;
[0034] Preparation method: Take 10g of precrossed starch and add 90g of water to prepare 100g of precrossed starch slurry with a concentration of 10% as a binder, and add it to a mixture consisting of 60g of losartan potassium, 60g of microcrystalline cellulose and 70g of precrossed starch. In the mixture, the soft material is granulated with a 30-mesh sieve, dried at 70°C until the water content is 2%, and then granulated with a 30-mesh sieve, and then mixed with 80g gliclazide, 40g anhydrous calcium hydrogen phosphate, and 8g silicon dioxide , 3g of magnesium stearate were uniformly mixed together and then pressed into tablets to obtain losartan pota...
Embodiment 3
[0036] A composition of losartan potassium and gliclazide and its preparation method:
[0037] The composition includes: 50g of losartan potassium, 40g of gliclazide, 50g of microcrystalline cellulose, 25g of anhydrous calcium hydrogen phosphate, 65g of precrossified starch, 6g of silicon dioxide, and 2g of magnesium stearate;
[0038] Preparation method: Take 9.6g of precrossed starch and add 70.4g of water to prepare 80g of precrossed starch slurry with a concentration of 12% as a binder, add 45g of losartan potassium, 50g of microcrystalline cellulose, 55.4g of precrossed starch In the mixture composed of starch, make soft material and then granulate with 24 mesh sieve, dry at 50°C until the water content is 3%, and then granulate with 30 mesh sieve, then mix with 40g gliclazide, 25g anhydrous calcium hydrogen phosphate, 6g Silicon dioxide and 2 g of magnesium stearate were uniformly mixed together, and then directly compressed into tablets to obtain tablets of the composit...
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