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Application of long-chain non-coding RNA and composition thereof for diagnosing and treating biliary duct cancer

A long-chain non-coding, cholangiocarcinoma technology, applied in the field of genetic engineering, can solve the problems of poor prognosis of patients with cholangiocarcinoma, malignant progression of cholangiocarcinoma, etc.

Inactive Publication Date: 2019-03-19
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are currently clinical treatments such as surgery, radiotherapy, and chemotherapy, the prognosis of patients with cholangiocarcinoma is still poor
Studies have shown that the abnormal expression of lncRNAs mediates the malignant progression of cholangiocarcinoma

Method used

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  • Application of long-chain non-coding RNA and composition thereof for diagnosing and treating biliary duct cancer
  • Application of long-chain non-coding RNA and composition thereof for diagnosing and treating biliary duct cancer
  • Application of long-chain non-coding RNA and composition thereof for diagnosing and treating biliary duct cancer

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Embodiment

[0086] Embodiment: The present invention is further described below with embodiment, but the present invention is not limited thereto. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed.

[0087] 1. Bioinformatics screening and identification of high expression LINC00152 in cholangiocarcinoma

[0088] (1) Inclusion criteria Enter the GEO database and TCGA database, query "cholangiocarcinoma" and "cancer of biliary duct", limit the filter conditions "Entry type: Series", "Organism: Homo sapiens", "Study type: Expression profiling by array" and "Attribute name: tissue", obtain the query results of microarray research on cholangiocarcinoma, and select research projects that meet the following requirements: cholangiocarcinoma, including case-control (or cancer-adjacent), mainstream microarray platforms (Affy, Agilent, and Illumina ), single-c...

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Abstract

The invention belongs to the field of the gene engineering, and particularly relates to an application of a long-chain non-coding RNA LINC00152 and a composition thereof in biliary duct cancer diagnosis and target drug treatment. In addition, the invention further relates to an application of a primer thereof for preparing a reagent of diagnosing colorectal cancer. Through researching expression of the long-chain non-coding RNA in a cellular level, a relation between the long-chain non-coding RNA and biliary duct cancer pathogenesis is disclosed. Molecular mechanisms of lncRNAs for controllingoccurrence and development of the biliary duct cancer are enriched through successful implementation of the research. It is disclosed that the LINC00152 can be used as a marker of biliary duct cancerdiagnosis and prognosis, and an experimental and theoretical basis is provided for early-stage biliary duct cancer clinical diagnosis and treatment.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, LINC00152 and its composition, and its application in the preparation and diagnosis of cholangiocarcinoma and target drug treatment. At the same time, the present invention also relates to the application of the primers in the preparation of reagents for diagnosing colorectal cancer. By studying the expression of the long non-coding RNA at the cellular level, the relationship between it and the pathogenesis of cholangiocarcinoma was revealed. Background technique [0002] Tumor is a major culprit that seriously threatens human health, and the research on the molecular mechanism of tumor malignant progression has always been the focus and difficulty of the academic circle. It has been reported that tumor cells have cell phenotype characteristics such as promoting proliferation, invasion and metastasis, continuous angiogenesis, immune tole...

Claims

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Application Information

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IPC IPC(8): C12N15/113C12Q1/6886C12N15/11A61K31/713A61P35/00
CPCA61K31/713A61P35/00C12N15/113C12N2310/10C12Q1/6886C12Q2600/158C12Q2600/178
Inventor 缪林王妮季国忠于洋李全朋葛贤秀王飞
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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