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Evaluation method for blood vessel stimulation of mesenchymal stem cell preparation and application

A technology of mesenchymal stem cells and evaluation methods, which is applied in the field of evaluation of vascular irritation of mesenchymal stem cell preparations, and can solve the problems of lack of evaluation indicators and technical means.

Inactive Publication Date: 2019-03-19
TIANJIN CHANGHE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a special drug, stem cells lack evaluation indicators and corresponding technical means in the preclinical safety evaluation, especially in the evaluation of vascular stimulation.

Method used

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  • Evaluation method for blood vessel stimulation of mesenchymal stem cell preparation and application
  • Evaluation method for blood vessel stimulation of mesenchymal stem cell preparation and application
  • Evaluation method for blood vessel stimulation of mesenchymal stem cell preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 1. Experimental design

[0081] 1.1. Group settings:

[0082] The mesenchymal stem cell preparation used in this example includes human umbilical cord mesenchymal stem cells isolated from umbilical cord blood and human umbilical cord mesenchymal stem cells without human source protein; this experiment sets up 3 groups, and the umbilical cord mesenchymal stem cells are respectively set at low doses and high-dose groups (abbreviated as low-dose group and high-dose group), and set up a blank control group with 0.9% sodium chloride injection simultaneously. There are 4 rabbits in each group, half male and half male, and one group of animals is used in the low-dose group and the blank control group, and the left and right ears of the rabbits are administered respectively.

[0083] 1.2. Dose setting and basis

[0084] Umbilical cord mesenchymal stem cells (MSCs) have multi-lineage differentiation function and can differentiate into various cells. This research intends to us...

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Abstract

The invention provides an evaluation method for blood vessel stimulation of a mesenchymal stem cell preparation and an application and relates to the biotechnical field. The evaluation method for blood vessel stimulation of the mesenchymal stem cell preparation comprises the following steps: making animals immune with the mesenchymal stem cell preparation, wherein the immune animals are divided into a low dosage group and a high dosage group; and then dividing blood vessel stimulation of the mesenchymal stem cell preparation into preset grades according to symptoms of the immune animals. The method also provides a reasonable drug dosage at the low and high dosages, which solves the problem that the evaluation result is inaccurate as the delivery amount is unreasonable, and alleviates the condition that an evaluation method for blood vessel stimulation of the mesenchymal stem cell preparation is in short in the prior art.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method and application for evaluating the vascular stimulation of mesenchymal stem cell preparations. Background technique [0002] Mesenchymal stem cells originate from the mesoderm and ectoderm in the early stages of development and belong to pluripotent stem cells. They have attracted increasing attention because of their characteristics of multi-lineage differentiation potential, hematopoietic support and promotion of stem cell implantation, immune regulation and self-replication. Mesenchymal stem cells can differentiate into fat, bone, cartilage, nerve, endothelial and other tissue cells under specific induction conditions in vivo or in vitro, and they still have multi-directional differentiation potential after continuous subculture and cryopreservation. Seed cells are used for the repair of tissue and organ damage caused by aging and disease. [0003] According to the data ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N33/48A61K35/28A61P19/08A61P25/28A61P3/10A61P9/10A61P21/04A61P1/16
CPCA61K35/28A61P1/16A61P3/10A61P9/10A61P19/08A61P21/04A61P25/28G01N1/28G01N33/48
Inventor 李伟李政楠王秀娟徐永胜
Owner TIANJIN CHANGHE BIOLOGICAL TECH
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