Biosensor based on Au-ZIF-8/OMC mesoporous carbon and preparation method thereof

A biosensor, ZIF-8 technology, applied in the field of biosensors, can solve problems such as poor conductivity and limit the application of MOFs, and achieve the effects of overcoming poor conductivity, improving detection performance, and reducing interference

Active Publication Date: 2019-03-19
SHANGHAI PUDONG HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor conductivity of most MOFs materials, the application of MOFs in the field of electrochemistry is limited.

Method used

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  • Biosensor based on Au-ZIF-8/OMC mesoporous carbon and preparation method thereof
  • Biosensor based on Au-ZIF-8/OMC mesoporous carbon and preparation method thereof
  • Biosensor based on Au-ZIF-8/OMC mesoporous carbon and preparation method thereof

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Experimental program
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Embodiment Construction

[0033] The technical solution of the present invention will be described in detail below in conjunction with Embodiment 1.

[0034] A method for preparing a biosensor based on Au-ZIF-8 / OMC mesoporous carbon, comprising the steps of:

[0035] Synthesis of ZIF-8

[0036] Dissolve 1.487g of Zn(NO3)2·6H2O in 30ml of methanol solution; dissolve 1.642g of 2-methylimidazole in 30ml of methanol solution. Slowly pour the Zn(NO3)2·6H2O solution into the dimethylimidazole solution while stirring with a glass rod until the solution changes from colorless and transparent to milky white. The resulting milky white liquid was transferred to a 110°C autoclave, and then heated and dried in a vacuum oven at 110°C for 18 hours (temperature increase 5°C / h, temperature drop 4°C / h). The obtained white powder was repeatedly washed with methanol solution and centrifuged to obtain a precipitate, which was added to a reaction kettle at 110° C. for reaction and then dried in vacuum at 80° C. for 12 hou...

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Abstract

The invention provides a biosensor based on Au-ZIF-8 / OMC mesoporous carbon and a preparation method thereof. The biosensor comprises a working electrode which comprises a glass carbon electrode (GCE),the surface of the detection end of the GCE is sequentially connected with nitrogen-hybridized mesoporous carbon (OMC) and a gold (Au) nanoparticle film which is formed by a metal organic frame ZIF-8loaded with gold (Au), in other words, the biosensor is Au-ZIF-8 / OMC / GCE. The biosensor has good adsorption and storage functions, detection performance of an electrode is improved greatly by combining with a mesoporous carbon material high in conductivity, and xanthine (Xa) can be detected efficiently.

Description

technical field [0001] The invention relates to a biosensor, in particular to a biosensor based on Au-ZIF-8 / OMC mesoporous carbon and a preparation method thereof. Background technique [0002] Xanthine (Xa) is the main intermediate product in the metabolism of adenine and guanine in nucleotides. It is produced from hypoxanthine catalyzed by xanthine oxidase, and then oxidized into the final product uric acid by xanthine oxidase and excreted. The level of Xa in human body fluid can be used as a diagnostic monitoring indicator for many clinical diseases, such as infant perinatal asphyxia, respiratory distress syndrome, cerebral hemorrhage, tumor hyperthermia, preeclampsia xanthine urine, renal failure, gout, hyperuricemia disease etc. Timely and accurate detection of Xa is of great significance to the diagnosis and treatment monitoring of clinically relevant diseases. [0003] At present, the main detection methods of Xa include high performance liquid chromatography, elect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/327
Inventor 常东张泽于洪伟
Owner SHANGHAI PUDONG HOSPITAL
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