Application of hsa-mir-145-5p in the treatment of breast cancer

A breast cancer and sensitivity technology, applied in the biological field, can solve problems such as ambiguity, and achieve the effects of weakening activity, reducing mortality, and reducing drug resistance
CN109512834BActive Publication Date: 2021-04-20TSINGHUA BERKELEY SHENZHEN INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TSINGHUA BERKELEY SHENZHEN INST
Publication Date
2021-04-20

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Abstract

The invention discloses the application of hsa-miR-145-5p in the treatment of breast cancer. The invention finds that increasing the content of hsa-miR-145-5p in tumor cells significantly reduces the drug resistance of cancer cells and weakens the tumor cells activity for the treatment of breast cancer. Combining hsa-miR-145-5p with calcineurin inhibitors may be a means to improve chemotherapy drugs and reduce breast cancer mortality, and greatly improve the effect of anti-tumor drugs on tumor cells.
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Description

technical field

[0001] The invention belongs to the field of biotechnology and relates to tumor molecular markers, in particular to the application of hsa-miR-145-5p in treating breast cancer and improving the sensitivity of breast cancer to therapeutic drugs. Background technique

[0002] The latest global statistical analysis of tumors in 2018 covers 185 countries and regions and 36 types of cancer. It mainly analyzes the incidence and mortality of each cancer in 2018, as well as the incidence of tumors in various regions. Statistics show that so far, there are about 18.19 million new cancer cases and 9.6 million cancer deaths worldwide. Asia accounts for about 50% of new cancer cases and 70% of cancer deaths. The final analysis results show that breast cancer is the number one "killer" of women (globally, there will be about 2.1 million newly diagnosed female breast cancer cases in 2018), and among the diagnosed female cancer cases worldwide, breast cancer Accounting for...

Claims

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