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High-strength degradable hydrogel and preparation method thereof

A hydrogel, high-strength technology, applied in medical science, surgery, etc., can solve the problem that degradability and high strength cannot be realized under the same conditions, and achieve the effect of good mechanical properties

Inactive Publication Date: 2019-03-26
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, strictly speaking, PACG hydrogels are not really high-strength degradable hydrogels because their degradability and high strength cannot be achieved under the same conditions.

Method used

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  • High-strength degradable hydrogel and preparation method thereof
  • High-strength degradable hydrogel and preparation method thereof
  • High-strength degradable hydrogel and preparation method thereof

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Embodiment Construction

[0016] The technical solutions of the present invention will be further described below in conjunction with specific embodiments. The medicines and instruments used in the embodiments of the present invention are all commercially available conventional medicines and equipment. N-acryloylglycine (ACG) is prepared from acryloyl chloride and glycine according to the references. It will not be repeated here. For specific reference, Gao , F.; Zhang, Y.; Li, Y.; Xu, B.; Cao, Z.; Liu, W. Sea cucumber-inspired autolytic hydrogels exhibiting tunable high mechanical performances, repairability, and reusability.ACSAppl.Mater.Interfaces, 2016, 8, 8956-8966. Methacrylated gelatin is prepared from methacrylic anhydride and gelatin, according to references (Resmi, R.; Unnikrishnan, S.; Krishnan, L.K.; Krishnan, V.K. Synthesis and characterization of silver nanoparticle incorporated gelatin-hydroxypropyl methacrylate Hydrogels for wound dressing applications.J.Appl.Polym.Sci.2017,134,44529) ...

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Abstract

The invention discloses high-strength degradable hydrogel and a preparation method thereof. According to the preparation method, methylacryloyl gelatin is crosslinked with poly(N-acryloylglycine), andthe degradability of the methylacryloyl gelatin and the high strength of the poly(N-acryloylglycine) hydrogel are combined, so that the gel has high strength and degradability.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and more specifically relates to the preparation of a high-strength degradable hydrogel, specifically a kind of N-acryloylglycine-methacryloyl gelatin (P(ACG / GelMA) ) preparation of hydrogel, which utilizes methacrylylated gelatin to cross-link poly-N-acryloylglycine, which combines the degradability of methacrylylated gelatin and poly-N-acryloylglycine hydrogel High strength, the gel has high strength properties and degradability at the same time. Background technique [0002] In the past decade, thanks to the rapid development of high-strength hydrogel systems such as double network hydrogels, nanocomposite hydrogels, and supramolecular hydrogels, hydrogels are not limited to a "soft and wet" material. At the same time, because the high-strength hydrogel still retains the characteristics of high water content of the hydrogel, that is to say, the high-strength hydrogel can provide a benefici...

Claims

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Application Information

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IPC IPC(8): C08F290/00C08F220/58A61L31/04A61L31/14
CPCA61L31/048A61L31/14A61L31/145A61L31/148C08F290/00C08F220/58C08L51/00
Inventor 刘文广张絮然
Owner TIANJIN UNIV
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