A pharmaceutical composition containing levocarnitine and its preparation method and application
A composition and drug technology, applied in the field of pharmaceutical preparations, can solve the problems of short ocular residence time, low bioavailability, and poor patient tolerance, and achieve the goal of avoiding blurred vision, high bioavailability, and high drug concentration Effect
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[0076] Secondly, the present invention provides a preparation method of the above-mentioned pharmaceutical composition containing levocarnitine. The preparation method comprises the following steps:
[0077] 1) Prepare an aqueous tackifier solution: add the tackifier to a part of pharmaceutical water, disperse, swell and dissolve it at room temperature to obtain an aqueous tackifier solution;
[0078] 2) Prepare a blank thermosensitive in-situ gel: add the gel matrix to the thickener aqueous solution obtained in step 1), stir evenly, and place it at 4°C for more than 24 hours to obtain a blank thermosensitive in-situ gel;
[0079] 3) Preparation of the drug-loaded thermosensitive in situ gel: add levocarnitine to the blank thermosensitive in situ gel obtained in step 2), place it at room temperature, add another part of pharmaceutical water to the full amount, and stir evenly to obtain the drug-loaded thermosensitive in situ gel The bit gel is a pharmaceutical composition con...
Embodiment 1
[0086] Example 1: Preparation of a pharmaceutical composition (LC thermosensitive in situ gel formulation) containing levocarnitine.
[0087] Weigh 0.1g HA-Na and 0.3g CMC-Na, add them into 600mL purified water, disperse, swell and dissolve HA-Na and CMC-Na at room temperature to obtain an aqueous solution of tackifier. Add 0.1g of P407 and 0.2g of P188 to the above-mentioned thickener aqueous solution, stir evenly, put it in a refrigerator at 4°C for more than 24 hours, and obtain a clear and uniformly dispersed blank temperature-sensitive in-situ gel. Add 10g of levocarnitine (LC) to the above blank thermosensitive in situ gel, place it at room temperature, add 400mL of purified water to the full amount (1L), stir evenly, and dissolve levocarnitine to obtain LC thermosensitive in situ gel. Gum (ie pharmaceutical composition comprising levocarnitine).
Embodiment 2
[0088] Example 2: Preparation of a pharmaceutical composition (LC thermosensitive in situ gel formulation) containing levocarnitine.
[0089] Weigh 2.6g of HA-Na and 10.4g of CMC-Na, add them into 800mL of purified water, disperse, swell and dissolve HA-Na and CMC-Na at room temperature to obtain an aqueous thickener solution. Add 300g of P407 and 150g of P188 to the above-mentioned thickener aqueous solution, stir evenly, put it in a refrigerator at 4°C for more than 24 hours, and obtain a clear and uniformly dispersed blank temperature-sensitive in-situ gel. Add 10g of levocarnitine (LC) to the above blank thermosensitive in situ gel, place it at room temperature, add 200mL of purified water to the full amount (1L), stir evenly, and dissolve levocarnitine to obtain LC thermosensitive in situ gel. Gum (ie pharmaceutical composition comprising levocarnitine).
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