Total flavonoid extract of Epimedium brevicornum, preparation method and active application to sleep improvement

A technology of epimedium and total flavonoids is applied in the field of epimedium total flavonoids extract and its preparation, anti-insomnia and anti-insomnia auxiliary new drugs, which can solve the problems of application obstacles, toxic side effects and dependence affecting patients, etc. Competitiveness, sleep improvement, and the effect of expanding the range of applications

Inactive Publication Date: 2019-03-29
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insomnia has become a major public health problem, and there is no good solution at present. Clinically, the demand for drugs for the treatment of insomnia is gradually increasing. is a medical problem that affects patient adoption and hinders physician choice

Method used

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  • Total flavonoid extract of Epimedium brevicornum, preparation method and active application to sleep improvement
  • Total flavonoid extract of Epimedium brevicornum, preparation method and active application to sleep improvement
  • Total flavonoid extract of Epimedium brevicornum, preparation method and active application to sleep improvement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Take 3 kg of Epimedium medicinal material (dried leaves of Epimedium brevicomu Maxim. of the Berberidaceae plant), chop it into pieces as appropriate, add 24 kg of water to decoct and extract twice, each time for 2 hours.

[0022] (2) Combine the filtrates, filter while hot, concentrate to a volume of 1L, add to the treated D 101 A macroporous resin column with a column bed volume of 1 L was first eluted with 8 L of water and then 8 L of 95% ethanol. The eluate was concentrated and dried after recovering ethanol to obtain 117 g of crude extract of total flavonoids of Epimedium.

[0023] (3) Take the crude extract, stir with 936ml of 40% ethanol for 30 minutes, filter, concentrate the filtrate in a water bath to a thick paste, dry under reduced pressure, and make 73g of Epimedium total flavonoids extract. The total flavonoid content of the prepared Epimedium is 86%.

Embodiment 2

[0025] (1) Take 3kg of Epimedium medicinal material (dried leaves of Epimedium), crush it as appropriate, add 18kg of water to decoct and extract 3 times, 1 hour each time.

[0026] (2) Combine the filtrates, filter while hot, concentrate to a volume of 1L, add to the treated AB-8 macroporous resin column, the volume of the column bed is 1L, first wash with 6L of water, and then wash with 6L of 30% ethanol After the eluate was recovered from ethanol, it was concentrated and dried to obtain 127 g of crude extract of Epimedium total flavonoids.

[0027] (3) Take the crude extract, stir with 762ml of 75% ethanol for 20 minutes, filter, concentrate the filtrate in a water bath to a thick paste, dry under reduced pressure, and make 76g of Epimedium total flavonoids extract. The total flavonoid content of the prepared Epimedium is 52%.

Embodiment 3

[0029] (1) Take 3 kg of Epimedium medicinal material (dried leaves of Epimedium brevicomu Maxim. of the Berberidaceae plant), crush it as appropriate, add 27 kg of water to decoct and extract twice, 1.5 hours each time.

[0030] (2) Combine the filtrates, filter while hot, concentrate to a volume of 1L, add to the treated D 21 A macroporous resin column with a column bed volume of 1 L was first eluted with 10 L of water and then 10 L of 70% ethanol. The eluate was concentrated and dried after recovering ethanol to obtain 144 g of crude extract of total flavonoids of Epimedium.

[0031] (3) Take the crude extract, stir with 1440ml of 50% ethanol for 10 minutes, filter, concentrate the filtrate in a water bath to a thick paste, dry under reduced pressure, and make 52g of Epimedium total flavonoids extract. The total flavonoid content of the prepared Epimedium is 67%.

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Abstract

The invention relates to total flavonoid extract of Epimedium brevicornum, a preparation method and an active application to sleep improvement, and belongs to the technical field of pharmaceutical. Dry leaves of the Epimedium brevicornum are taken, chopped and decocted with water, water adding amount, extraction time and extraction times are controlled, extract liquids are mixed and filtered whilethe liquids are still hot, a filtrate is concentrated, a concentrate is added to pre-treated macroporous adsorption resin column, an eluate is collected, ethanol with concentration of 30%-95% is taken as a solvent, coarse extract is added to 4-12 times by weight of the solvent and stirred for 10-40 min, the mixed solution is filtered, a filtrate is concentrated into thick paste in a water bath and subjected to reduced-pressure drying, and the total flavonoid extract of the Epimedium brevicornum is prepared. The method is applicable to industrial production and preparation of the total flavonoid extract of the Epimedium brevicornum, the application range of the total flavonoid extract in the field of sleep improvement drugs and healthcare food is expanded, and broader idea is provided forcomprehensive development and utilization of the Epimedium brevicornum medicinal materials.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to an extract of total flavonoids of Epimedium herba and a preparation method thereof. The application of an anti-insomnia and anti-insomnia auxiliary new drug prepared from the extract can effectively improve sleep and achieve the purpose of treating insomnia. Background technique [0002] Chronic insomnia, as a common clinical chronic disease, is usually caused by factors such as staying up late for a long time. Its characteristics are that patients cannot fall asleep smoothly even in a sufficient sleep environment, and it is difficult to maintain sleep, which will make patients physically and mentally exhausted. , drowsiness, emotional and rhythm of life disorders, etc., and in severe cases, it can also cause dizziness, headache, palpitations, and strokes. Although insomnia itself is not fatal, it seriously affects the quality of life of human beings, and even causes cardiovascula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P25/20A61K127/00
CPCA61K36/296A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61P25/20
Inventor 王隶书程东岩高军于江波曲波陈昕
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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