Long-acting coagulation factor vii and methods of producing same

A technology of active factors and molecules, applied in coagulation/fibrinolytic factors, chemical instruments and methods, prolonging plasma life fusion, etc.
CN109563145APending Publication Date: 2019-04-02OPKO BIOLOGICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OPKO BIOLOGICS
Publication Date
2019-04-02

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Abstract

Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotidesencoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing sameare also disclosed.
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Description

technical field

[0001] Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin linked to the carboxy-terminus of a coagulation factor and polynucleotides encoding the polypeptides are disclosed. Also disclosed are pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing them. Background technique

[0002] The development of clotting factor replacement therapy has changed the lives of many individuals with hemophilia. Hemophilia is a group of inherited genetic disorders that impair the body's ability to control blood clotting, or clotting. People with hemophilia do not produce sufficient amounts of the Factor VIII or Factor IX proteins, which are necessary for effective blood clotting. In people with severe hemophilia, even minor injuries can cause blood loss for days or weeks, and complete healing may not occur, leading to possible p...

Claims

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