Preparation method of herba violae formula granules

A technology of Radix Radix and formula granules, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems such as formula granules of Radix Radix et Rhizoma that have not yet been seen, and achieves improved physical dissolution and transfer rate, and improved extraction. Transfer rate, effect of increasing transfer rate

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of Violadidin formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Preparation method of herba violae formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of Viola didin formula granules, comprising the steps of:

[0041] a. Select Viola dichotoma medicinal material, vibrate and sieve to remove impurities, and crush it into 0.5cm particles to obtain Viola dichotoma decoction pieces;

[0042] b. Wet the crushed Viola dichotoma decoction pieces with 2 times the amount of water, and continuously input them into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the front-end feeding port. Through a set of spiral structure, the material is continuously pushed forward to the slag outlet of the extraction tube for slag discharge, and 20 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material are reversed Flow to the front end of the leaching tubes at all levels to discharge the liquid, collect the extract, sque...

Embodiment 2

[0047] A preparation method of Viola didin formula granules, comprising the steps of:

[0048] a. Select Viola dichotoma medicinal material, vibrate and sieve to remove impurities, and crush it into 0.5cm particles to obtain Viola dichotoma decoction pieces;

[0049] b. Wet the crushed Viola dichotoma decoction pieces with 2 times the amount of water, and continuously input them into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the front-end feeding port. Through a set of spiral structure, the material is continuously pushed forward to the slag outlet of the extraction tube for slag discharge, and 20 times the amount of 95°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material are reversed Flow to the front end of the leaching tubes at all levels to discharge the liquid, collect the extract, sque...

Embodiment 3

[0054] A preparation method of Viola didin formula granules, comprising the steps of:

[0055] a. Select Viola dichotoma medicinal material, vibrate and sieve to remove impurities, and crush it into 0.5cm particles to obtain Viola dichotoma decoction pieces;

[0056] b. Wet the crushed Viola dichotoma decoction pieces with 2 times the amount of water, and continuously input them into the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the front-end feeding port. Through a set of spiral structure, the material is continuously pushed forward to the slag outlet of the extraction tube for slag discharge, and 18 times the amount of 85°C hot water is continuously added to the end of each level of extraction tube for continuous countercurrent extraction for 1 hour. The hot water and the material are reversed. Flow to the front end of the leaching tubes at all levels to discharge the liquid, collect the extract, squ...

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Abstract

The invention discloses a preparation method of herba violae formula granules. The preparation method comprises the steps: a, herba violae is broken or chopped, and thus herba violae decoction piecesare obtained; b, the herba violae decoction pieces are continuously input into extracting pipes of a continuous countercurrent extracting machine, hot water is added continuously and reversely into the tail ends of all the stages of extracting pipes for continuous dynamic countercurrent extracting, and an extracting solution is collected; c, the extracting solution is filtered, superhigh-temperature instantaneous sterilization is conducted, and filtrate is subjected to decompression concentration to form clear paste; d, auxiliary materials are added into the clear paste for dissolving, and spray drying is conducted to obtain dry extract powder; and e, preparation auxiliary materials are added into the dry extract powder, and dry granulation is conducted to obtain the herba violae formula granules. According to the preparation method of the herba violae formula granules, production processes of continuous countercurrent extracting, superhigh-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation are adopted, thus the content of effective components in the herba violae formula granules can reach the high level continuously and stably, it is guaranteed that the active component transfer rate and that of herba violae standard decoction are consistent, and the product quality of the herba violae formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Viola didin formula granules. Background technique [0002] Viola Viola is a Viola family plant Viola yedoensis The dried whole herb of Makino, recorded in the 2015 edition of "Chinese Pharmacopoeia", has the effects of clearing away heat and detoxification, cooling blood and reducing swelling. According to the relevant literature reports, the high content of acetaminophen was isolated from the effective part of Viola didin, which has obvious anti-inflammatory, antibacterial, analgesic, anti-oxidative, anti-tumor and immune regulation effects. This ingredient is included in " Hong Kong Chinese Materia Medica Standards (Volume 5), as an index compound for the quality control of Viola didin. Therefore, acetaminophen can be selected as an index for the determination of violadin content. Escin B, also known...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K9/16
CPCA61K9/1652A61K9/1682A61K36/86A61K2236/15A61K2236/331A61K2236/51
Inventor 林伟雄干丽刘远俊张雪兰陈伟媚胡瑶蔡盛康
Owner GUANGDONG YIFANG PHARMA
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