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Application of ilexin B in preparation of medicine for treating IBD (inflammatory bowel disease)

A technology for inflammatory bowel disease and glucoside, which is applied in the field of application of glucoside B in the preparation of drugs for treating inflammatory bowel disease, and can solve problems such as elevated lipase levels, high fever, and elevated transaminases

Inactive Publication Date: 2019-04-09
天津华泰至成医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of large doses of non-steroidal anti-inflammatory drugs can cause adverse reactions such as high fever, indigestion, diarrhea, elevated transaminases, and elevated lipase levels. Long-term use of corticosteroids and immunosuppressants can also cause dose-dependent

Method used

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  • Application of ilexin B in preparation of medicine for treating IBD (inflammatory bowel disease)
  • Application of ilexin B in preparation of medicine for treating IBD (inflammatory bowel disease)
  • Application of ilexin B in preparation of medicine for treating IBD (inflammatory bowel disease)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method of glucoside B

[0023] (1) Extraction: Obtained by relying on the preparation method of the root extract of G. gongguo (see patent: ZL201110314778.6 for the specific method).

[0024] (2) Separation by silica gel column: take the root extract of G. quinquefolius, dissolve it in an equal amount of methanol, add 60-100 mesh silica gel in a ratio of 1.5--2.5 times the amount, mix the sample under reduced pressure until dry, load the sample by dry method, and use 10- 20 times the amount of silica gel column chromatography, with dichloromethane-methanol volume ratio of 95:5, 93:7, 90:10 gradient elution, half the column bed volume as a receiving volume, by thin layer chromatography and Combined with analytical HPLC detection, collect the components rich in glucoside B, combine them, and concentrate them to dryness under reduced pressure at a temperature ≤ 60°C and a vacuum degree of 0.06-0.08 MPa to obtain a glucoside B enrichment with a content of 1...

Embodiment 2

[0034] Effect of glucoside B on experimental colopathy induced by dextran sulfate sodium in mice.

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Abstract

The invention discloses an application of ilexin B in preparation of a medicine for treating IBD (inflammatory bowel disease). Experiments prove that the ilexin B has the function of treating the IBDand exact curative effects. The new application of the natural product ilexin B is developed.

Description

technical field [0001] The invention relates to a new application of a natural product, in particular to the application of a glucoside B in the preparation of a medicine for treating inflammatory bowel disease. Background technique [0002] [0003] Triterpene saponins are an important class of natural products, which are distributed in many medicinal plants, such as ginseng, Panax notoginseng, Bupleuri, Polygala, etc. In recent years, studies have shown that many triterpenoid saponins have anti-inflammatory activity, such as prunella vulgaris saponin and asiaticoside, which can exert anti-inflammatory effects by inhibiting the release of inflammatory factors [1-2] . [0004] Gugongguogen, a medicinal material of the Yi nationality, has anti-inflammatory, antidiarrheal, and even therapeutic effects on inflammatory bowel disease. In the early stage, the unit has also obtained two national invention patents (ZL 201110314778.6, ZL 201310050653.6), from Gugongguogen There ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P1/00A61P29/00A61P1/04
CPCA61K31/704A61P1/00A61P1/04A61P29/00
Inventor 刘成航刘岱琳王春雷李新宇
Owner 天津华泰至成医药科技发展有限公司