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Phase difference analysis Doppler imaging method

An imaging method and phase difference technology, which are used in the analysis of materials, the measurement of phase influence characteristics, and the analysis of materials by optical means. Pule image and other problems, achieve high-speed detection sensitivity, achieve dynamic imaging, and overcome the effect of frequency mixing.

Active Publication Date: 2019-04-09
HUAQIAO UNIVERSITY
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Problems solved by technology

[0009] It can be seen that the OCT technology combined with Doppler forms a new type of biomedical imaging technology, but the current OCT technology is difficult to achieve dynamic image measurement of high-speed vibrating samples such as cardiovascular systems, the system's signal-to-noise ratio and system Modulation frequency is limited, making it difficult to obtain high speed detection sensitivity
In addition, when imaging living organisms, the large-amplitude and high-speed motion in the sample to be tested will cause the time spectrum after Fourier transform to alias (that is, mix), which will make it difficult to obtain the Doppler frequency spectrum of the sample to be tested. le image

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Embodiment Construction

[0037] An imaging method for obtaining a Doppler image by performing phase difference in the spatial domain by using a sinusoidal phase modulation complex frequency domain optical coherence tomography system. The specific steps of the method are as follows:

[0038] 1) Use the sinusoidal phase modulation complex frequency domain optical coherence tomography system to image biological samples that move at high speed and vibrate greatly: while the two-dimensional galvanometer system scans the sample horizontally (B-SCAN), the piezoelectric ceramic Drive the vibration of the reference mirror (M-SCAN) so that it makes a sinusoidal vibration acos(2πf c t+θ), thus introducing a sinusoidal phase 2kacos(2πf c t+θ), that is, sinusoidal phase modulation; the vibration of the sample can be expressed as: z 10 (t)=z 0 +bcos(2πf 0 t+θ 0 );

[0039] Among them, f c is the frequency of sinusoidal vibration of the reference mirror; b is the vibration amplitude of the sample to be tested;...

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Abstract

The invention discloses a phase difference analysis Doppler imaging method. The method comprises the following steps of: 1) imaging a to-be-tested sample which moves at a high speed and vibrates by alarge margin by utilizing a sine phase modulation complex frequency domain optical coherence tomography imaging system; 2) carrying out Fourier transformation on an acquired two-dimensional interference spectrum signal along a wave number domain; 3) extracting phase information of a complex chromatography signal, and carrying out difference processing on phases, at an acquisition time interval, ofthe signal one by one to obtain a two-dimensional chromatography phase difference which changes along time; 4) reconstructing a two-dimensional difference chromatography signal with the phase difference by using amplitudes of the two-dimensional chromatography phase difference which changes along with time and the complex chromatography signal which changes along with time; and 5) carrying out Fourier transformation on the two-dimensional difference chromatography signal with the phase difference, and carrying out sine phase demodulation to obtain a difference frequency domain chromatographysignal, wherein the phase information is a Doppler image, which changes along with time, of the tested biological sample.

Description

technical field [0001] The invention relates to the technical field of Fourier domain optical coherence tomography, in particular to a sinusoidal phase modulation complex frequency domain Doppler optical coherence tomography method. Background technique [0002] Optical coherence tomography OCT (optical coherence tomography, OCT) is an imaging technology with high-resolution, non-destructive, real-time imaging capabilities, and the characteristics of easy docking with existing instruments, so it has a broad application prospect. [0003] The development of OCT has successively formed two categories called time domain OCT and Fourier domain OCT. Time-domain OCT uses a reference mirror to scan axially to match the back-reflected scattered light at different depths of the sample. Time-domain OCT needs to scan axially point by point, and the imaging speed is limited. Fourier domain OCT does not need a moving mechanism for axial scanning. The beams returned by the sample and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/45G01N21/84
CPCG01N21/45G01N21/84
Inventor 蒲继雄陈红芩佐佐木修己陈子阳
Owner HUAQIAO UNIVERSITY
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