A Key Protein Identification Method Based on Tensor Random Walk

A technology of random walk and identification method, applied in the field of systems biology, can solve the problem of poor prediction performance of key proteins, and achieve the effect of good prediction performance
CN109637579BActive Publication Date: 2022-04-15CHANGSHA UNIVERSITY
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGSHA UNIVERSITY
Publication Date
2022-04-15

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for identifying key proteins based on tensor random walk, which includes the following steps: obtaining protein interaction network topology, protein structural domain information, gene expression information based on time series, and protein homology information; according to the above Information, establish the association relationship between different protein nodes in the protein node interaction; initialize the hub score of the protein node according to the protein homology information; establish a tensor model based on the association relationship between different protein nodes in the protein interaction; The tensor model is iteratively calculated to obtain the hub score of each protein node and sorted, and the top n protein nodes in the sequence are regarded as key proteins. The invention is simple and effective. Compared with other methods and tested on multiple data sets, it shows that the invention has better predictive performance in identifying key proteins.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of systems biology, in particular to a key protein identification method based on tensor random walk. Background technique

[0002] Protein is an essential component of all cell and tissue structures, and the most important material basis for life activities. However, the importance of different proteins to life activities is not the same. Usually those proteins that cause the loss of function of the protein complex after being deleted and cause the organism to fail to survive or develop are called key proteins. Key proteins are not only necessary for the survival and reproduction of organisms, but also play an important role in life activities. Therefore, the identification of key proteins helps to understand the internal organization and process of life activities at the system level. At the same time, a large number of studies have shown that key proteins (genes) are often disease-causing genes. It can be seen ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More