Multi-channel wireless closed-loop electrical nerve stimulation system for treating epilepsy

Abstract

The invention provides a multi-channel wireless closed-loop electrical nerve stimulation system for treating epilepsy. According to the multi-channel wireless closed-loop electrical nerve stimulationsystem, collecting electrodes and stimulation electrodes are implanted in multiple areas of the cerebral cortex or the deep brain region to collect and monitor electrical nerve physiological signals of the areas in real time, then, multi-dimension characteristics such as the time domain, the frequency domain and the complexity of the electrical nerve signals are extracted, the obtained characteristics are used as input of an individual two-stage classifier to detect epilepsy signals in real time, and electrical stimulation is applied to the corresponding epileptic seizure area according to thedetected result to inhibit epileptic seizure. Compared with a conventional system for treating epilepsy, the multi-channel closed-loop electrical nerve stimulation system has the advantages that detecting and treating are conducted in multiple areas, an epilepsy detection algorithm is high in performance and low in power consumption, and side effects brought by additional electrical stimulation are reduced; a good platform is provided for exploration and implementation of multi-area nerve loop electrical stimulation on treatment of epilepsy, and novel clinical epilepsy treatment equipment isexpected to be developed.

Description

technical field [0001] The invention relates to the fields of neuroscience scientific research and medical treatment, in particular to a multi-channel wireless closed-loop nerve electrical stimulation system for epilepsy treatment. Background technique [0002] Nerve electrical stimulation technology uses surgery to implant electrodes in specific areas of the brain or spinal cord, and regulates the activities of related neurons through electrical stimulation, so as to achieve the purpose of treating neurological diseases. Nerve electrical stimulation technology has the advantages of being relatively safe, reversible, and postoperatively adjustable compared with traditional damage surgery, and has achieved remarkable curative effects in some neurological diseases such as essential tremor and Parkinson's disease. [0003] In recent years, nerve electrical stimulation has become a new technology in the treatment of clinical refractory epilepsy, among which vagus nerve stimulati...

AI Technical Summary

Problems solved by technology

At the same time, the vast majority of epilepsy research directions and commercial stimulators only use a single area or multiple areas for joint detection to stimulate a single area, and most of them choose the epilepsy focus area. The effect of the case remains to be further studied

In addition, there are many types of selection in terms of stimulation parameters for epilepsy suppression. It has been reported in relevant literature that high-frequency and low-frequency single-channel response electrical stimulation has inhibitory effects on epilepsy, and it has a direct relationship with the object model and stimulation area. However, there are currently no specific parameters for electrical stimulation therapy for different types of drug-refractory epilepsy, such as pulse width, stimulation frequency, and stimulation time.

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