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Preparation method for aerogel-hydrogel compound drug carrier and prepared carrier

An aerogel and hydrogel technology, applied in the field of preparation methods and prepared carriers, can solve the problems of limited load capacity of hydrogels and low mechanical properties of aerogels, and achieve improved diffusion uniformity and easy intelligence. and controlled release, the effect of increasing the application range

Pending Publication Date: 2019-04-26
安徽科昂纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problem to be solved by the present invention is to provide a composite drug carrier composed of airgel and hydrogel materials to solve the problems of low mechanical properties of airgel and limited loading capacity of hydrogel

Method used

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  • Preparation method for aerogel-hydrogel compound drug carrier and prepared carrier
  • Preparation method for aerogel-hydrogel compound drug carrier and prepared carrier
  • Preparation method for aerogel-hydrogel compound drug carrier and prepared carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of an airgel-hydrogel composite drug carrier, comprising the following steps:

[0042] (1) 5g of sodium alginate and 95g of water were magnetically stirred and mixed for 3 hours at a temperature of 80° C. to form a transparent solution;

[0043] (2) 1g of airgel powder is mixed with 3g of borage oil, and mixed with the transparent solution obtained in step (1) to obtain an airgel-borage oil mixture; the airgel powder used in this example is SiO 2 Aerogel;

[0044] (3) The airgel-borage oil mixture was mixed for 3 hours by ball milling;

[0045] (4) Mix 5g CaCl with magnetic stirring 2 Mix with 200g of water to form a transparent solution;

[0046] (5) Add dropwise the mixture after ball milling in step (3) to CaCl through a dropper 2 In the solution, the airgel-hydrogel composite drug carrier is formed by curing and cross-linking.

[0047] Experimental results: figure 2 It is the principle diagram of the airgel-hydrogel composite drug carrier...

Embodiment 2

[0050] A preparation method of an airgel-hydrogel composite drug carrier, comprising the following steps:

[0051] (1) 10 g of polyvinyl alcohol and 95 g of water were magnetically stirred and mixed for 3 hours at a temperature of 95° C. to form a transparent solution;

[0052] (2) 1g of airgel powder is mixed with 3g of alfalfa extract oil, mixed with the transparent solution obtained in step (1) to obtain an airgel-borage oil mixture; the airgel powder used in this embodiment is TiO 2 Aerogel;

[0053] (3) airgel-alfalfa extract oil was mixed for 3 hours by ball milling;

[0054](4) 0.1 g of sodium borate and 10 g of water are mixed by magnetic stirring to form a transparent solution;

[0055] (5) The solutions obtained in step (3) and step (4) were mixed for 3 minutes, and left to stand for 2 hours to form an airgel-hydrogel composite drug carrier.

Embodiment 3

[0057] A preparation method of an airgel-hydrogel composite drug carrier, comprising the following steps:

[0058] (1) 10 g of polyvinyl alcohol and 90 g of water were magnetically stirred and mixed for 3 hours at a temperature of 95° C. to form a transparent solution;

[0059] (2) 1g airgel powder is mixed with 3g isopropyl palmitate, and mixed with the transparent solution obtained in step (1) to obtain airgel-borage oil mixture; the airgel powder used in this embodiment is Al 2 o 3 Aerogel;

[0060] (3) Airgel-isopropyl palmitate was mixed for 3 hours by ball milling;

[0061] (4) freezing the solution obtained in step (3) at minus 60° C. for 12 hours;

[0062] (5) melting the material obtained in step (4) at 25° C. for 12 hours;

[0063] (6) freezing the solution obtained in step (5) at minus 60° C. for 12 hours;

[0064] (7) The material obtained in step (6) was melted at 25° C. for 12 hours to obtain an airgel-hydrogel composite drug carrier.

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Abstract

The invention discloses a preparation method for an aerogel-hydrogel compound drug carrier and relates to the field of drug carriers. The invention provides the preparation method, in order to solve the problems of low mechanical property of aerogel and limited load capacity of hydrogel. The preparation method comprises the following steps: loading active drugs in ducts of an aerogel material; forming an aerogel skeleton by using hydrophilic macromolecules and water; uniformly dispersing the aerogel material with loaded active materials in hydrogel. The invention has the beneficial effects that the maximization of drug load capacity can be guaranteed, the optimal strength of the carrier during transmission process can be guaranteed, and the intelligent and controllable drug release can berealized.

Description

technical field [0001] The invention relates to the field of drug carriers, in particular to a method for preparing an airgel-hydrogel composite drug carrier and the prepared carrier. Background technique [0002] Airgel is a material with high porosity, high surface area, low density and nanoporous structure properties. By chemically modifying the surface of airgel pores, aerogels can have very rich surface functions. Airgel materials can be used in construction, industry, cosmetics, biochemistry and many other fields. Airgel has very high porosity and nano-sized pores, which can load a large amount of active drugs in the pores, and can achieve uniform and slow release through chemical groups on the surface. The U.S. patent with the patent number US20020094318A1 reported the use of airgel as the carrier of two drugs, Methadone and Methadone Hydrochloride. The airgel carrier can effectively control the drug from being absorbed excessively. The Chinese patent with the paten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K47/36A61K47/32
CPCA61K47/32A61K47/36A61K9/0087A61K9/06
Inventor 张尚权
Owner 安徽科昂纳米科技有限公司
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