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Intestinal mucosa repair agent for weaned piglets

A technology for weaning piglets and repairing agent, applied in animal feed, additional food elements, animal husbandry, etc., can solve problems such as insufficient repair of intestinal damage, cell energy metabolism disorder, excessive mitochondrial degradation, etc., to improve intestinal mucosal absorption and absorption. Barrier function, protect mitochondrial function, improve intestinal morphology

Active Publication Date: 2019-04-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the compensatory mitophagy caused by weaning stress is not enough to repair the intestinal damage caused by weaning stress. So far, there has been no report on promoting intestinal mucosal repair and alleviating weaning stress by regulating mitochondrial function and mitophagy.
However, mitophagy is also a double-edged sword. Excessive or disordered mitophagy can lead to excessive degradation of mitochondria in cells, causing cellular energy metabolism disorders, and even cell death.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0020] Preparation: According to the method of "ZnO / montmorillonite for photocatalytic and photochemical degradation of methylene blue" (see: Fatimah, I, Wang, SB, Wulandari, D. Appl. Clay Sci. 2011, 53, 553-560.) Prepare montmorillonite loading Zinc oxide. In terms of weight percentage, the zinc oxide content in the montmorillonite supported zinc oxide is 3%.

[0021] Take 0.5 kg of tannic acid, 1 kg of carvacrol, 0.5 kg of L-carnitine, and 6 kg of montmorillonite-loaded zinc oxide and mix well to obtain an intestinal mucosa repair agent for weaned piglets (Intestinal mucosa repair agent for weaned piglets, IRA). The addition amount in piglet feed is 0.02wt.%.

[0022] A total of 108 21-day-old “Du×Long×Da” weaned piglets with an average body weight of 6 kg were selected and randomly divided into 6 groups: control group, tannic acid group, carvacrol group, L-carnitine group, and montmorillonite group. Lime-loaded ZnO group and IRA group. The control group was fed with con...

Embodiment 2

[0028] Preparation: According to the method of "ZnO / montmorillonite for photocatalytic and photochemical degradation of methylene blue" (see: Fatimah, I, Wang, SB, Wulandari, D. Appl. Clay Sci. 2011, 53, 553-560.) Prepare montmorillonite loading Zinc oxide. In terms of weight percentage, the zinc oxide content in the montmorillonite supported zinc oxide is 5%.

[0029]Take 0.9 kg of tannic acid, 0.5 kg of carvacrol, 1.5 kg of L-carnitine, and 15 kg of montmorillonite-loaded zinc oxide and mix well to obtain an intestinal mucosa repair agent for weaned piglets (Intestinal mucosa repair agent for weaned piglets, IRA). The addition amount in piglet feed is 0.08wt.%.

[0030] In the experiment, 108 28-day-old “Du×Long×Da” weaned piglets with an average body weight of 7kg were randomly divided into 6 groups, namely: control group, tannic acid group, carvacrol group, L-carnitine group, and montmorillonite group. Lime-loaded ZnO group and IRA group. The control group was fed with...

Embodiment 3

[0036] Preparation: According to the method of "ZnO / montmorillonite for photocatalytic and photochemical degradation of methylene blue" (see: Fatimah, I, Wang, SB, Wulandari, D. Appl. Clay Sci. 2011, 53, 553-560.) Prepare montmorillonite loading Zinc oxide. In terms of weight percentage, the zinc oxide content in the montmorillonite supported zinc oxide is 7%.

[0037] Take 2.5 kg of tannic acid, 1.5 kg of carvacrol, 1 kg of L-carnitine hydrochloride, and 20 kg of montmorillonite-loaded zinc oxide and mix well to obtain an intestinal mucosa repair agent for weaned piglets. forweaned piglets, IRA). The addition amount in piglet feed is 0.04wt.%.

[0038] In the experiment, 108 25-day-old "Du Changjia" weaned piglets with an average body weight of 6.5kg were randomly divided into 6 groups, namely: control group, tannic acid group, carvacrol group, L-carnitine hydrochloride group, Montmorillonite supported ZnO group and IRA group. The control group was fed with conventional p...

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Abstract

The invention discloses an intestinal mucosa repair agent for weaned piglets. The repair agent is prepared from 0.5-2.5 parts by weight of tannic acid, 0.5-1.5 parts by weight of carvacrol, 0.5-1.5 parts by weight of L-carnitine compounds and 6-20 parts by weight of montmorillonite-loaded zinc oxide. Compared with feed which is singly added with the tannic acid, the carvacrol, the L-carnitine compounds or the montmorillonite-loaded zinc oxide, the intestinal mucosa repair agent provided by the invention can reduce the diarrhea rate of the piglets by 75% or above, increase the height of intestinal villi and significantly improve the intestinal absorption and barrier functions of the piglets. The four components have significant interactions in the aspects of promoting intestinal mucosal repair, improving mitochondrial function and promoting mitochondrial autophagy, and have a positive synergistic combination effect. Furthermore, montmorillonite has a controlled release effect on the tannic acid, the carvacrol and the L-carnitine compounds, thus enabling the tannic acid, the carvacrol and the L-carnitine compounds to be easily mixed with the feed and further forming a uniform dispersion system; the repair agent is convenient to use. The intestinal mucosa repair agent for the weaned piglets can significantly protect the mitochondrial function of the weaned piglets and promote theintestinal mucosa repair by means of the synergistic effect of all the components, thereby greatly improving the absorption and barrier functions of the intestinal mucosa.

Description

technical field [0001] The invention relates to an agent for repairing intestinal mucosa of weaned piglets. Background technique [0002] In order to increase the number of litters per year, avoid cross-infection of diseases between sows and piglets, and increase economic benefits, piglets are usually weaned early in production. However, because weaning stress affects the morphological structure of piglet intestinal tissue, the balance of microecological flora in the digestive tract, the development and soundness of the immune system and enzyme system, and the renewal of intestinal mucosal cells, weaned piglets are prone to suffer from "early weaning of piglets". Syndrome", specifically manifested as decreased feed intake, digestive system disorders, diarrhea, reduced feed utilization, and growth retardation. [0003] Early weaning causes morphological and functional lesions in the gut of piglets, such as deepened crypts, shortened villi, and decreased activity of brush dig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K33/30A61P1/00A23K50/30A23K50/60A23K20/10A23K10/30A23K20/28A23K20/142A61K31/7024A61K31/05A61K31/205
CPCA61K31/05A61K31/205A61K31/7024A61K33/06A61K33/30A23K10/30A23K20/10A23K20/142A23K20/28A23K50/30A23K50/60A61P1/00A61K2300/00
Inventor 胡彩虹曹舒婷冯杰王春春肖勘宋泽和
Owner ZHEJIANG UNIV
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