The invention discloses health care capsule for relieving physical fatigue and a preparation method thereof. The health care capsule is prepared from the following raw materials in parts by weight: 70-80 parts of dogwood, 55-65 parts of herba epimedii, 40-50 parts of ginseng, 35-45 parts of radix acanthopanacis semticosi, 20-30 parts of cushaw flower, 30-40 parts of wolfberry fruit, 40-50 parts of rhizoma polygonati, 25-35 parts of centella, 50-60 parts of poria cocos, 20-30 parts of lucid ganoderma, 15-25 parts of lilium brownie, 20-30 parts of notoginseng flower, 35-45 parts of morinda officinalis, 40-50 parts of broadleaf holly leaf, 30-40 parts of polygonum multiflorum, 60-70 parts of astragalus membranaceus, 10-20 parts of folium cortex eucommiae, 20-30 parts of gynostemma pentaphylla, 15-25 parts of pollen pini and 10-20 parts of spiral seaweed powder. Through combination of all the raw medicines, the health care capsule disclosed by the invention has the effects of benefiting the vital energy, nourishing the kidneys, calming the heart, relieving uneasiness, nourishing yin, enriching blood, invigorating the spleen, nourishing the lungs, benefiting essence, replenishing marrow, reinforcing primordial spirit, consolidating the health and the like, so that the effects of relieving the fatigue, tiredness and powerlessness, improving the physical strength and corporeity and enhancing the body immunity are achieved; moreover, the health care capsule is accurate in curative effect, safe and reliable, becomes effective rapidly, can be used for remarkably improving the living quality and work efficiency of a person who easily feels tired, causes no side effects and adverse reaction, and has a wide market prospect.