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Nanometer material as well as preparation method and application thereof

A nano-material and reaction technology, applied in the field of nano-biomedical materials, can solve problems affecting the distribution and metabolism of diagnostic and therapeutic materials, poor dispersion and aggregation of products, and complicated preparation process, so as to improve imaging and treatment effects, reduce synthesis steps and synthesis time , the effect of simple reaction conditions

Active Publication Date: 2019-04-26
INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Lanthanide metals have inherent superparamagnetism and X-ray absorption ability, and are usually used as raw materials for MRI and CT imaging probes, but these nanomaterials usually require harsh synthesis conditions (high temperature, time-consuming), complicated preparation process, and Multi-step modification is required, and the obtained product has poor dispersion and is easy to aggregate, which affects the distribution and metabolism of medical materials in the body, further limiting its clinical application

Method used

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  • Nanometer material as well as preparation method and application thereof
  • Nanometer material as well as preparation method and application thereof
  • Nanometer material as well as preparation method and application thereof

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preparation example Construction

[0088] In a second aspect, in at least one embodiment, a method for preparing the aforementioned nanomaterial is provided, comprising the following steps:

[0089] (a) BSA:RE 1 , RE 2 The synthesis of: the BSA solution, RE 1 Saline solution and RE 2 After the salt solution is mixed evenly, the pH of the mixed solution is adjusted to alkaline, and BSA:RE is obtained after the reaction 1 , RE 2 ;

[0090] (b)BSA:RE 1 , RE 2 Synthesis of @PDA: dopamine salt solution and BSA:RE 1 , RE 2 After the solution is mixed evenly, the pH of the mixed solution is adjusted to alkaline, and BSA:RE is obtained after the reaction 1 , RE 2 @PDA;

[0091] (c)BSA:RE 1 , RE 2 Synthesis of @PDA-FA: Combine activated FA with BSA:RE 1 , RE 2 @PDA solution is mixed and reacted in the dark, and BSA:RE is obtained after the reaction 1 , RE 2 @PDA-FA nanomaterials.

[0092] In the above preparation method, BSA can be combined with rare earth ion RE through biomineralization method 1 and...

Embodiment 1

[0140] A kind of nanometer material BSA:Gd, Dy@PDA-FA, its preparation method comprises the following steps:

[0141] (a) Synthesis of BSA: Gd, Dy: In a 37°C water bath, take 300 mg of BSA in a 50 ml flask, add 10 ml of deionized water to dissolve it; take another 30 mg of GdCl 3 ·6H 2 O and 30 mg DyCl 3 ·6H 2 O was dissolved in 10 ml of water, slowly added to the above BSA solution under vigorous stirring, and the reaction solution became cloudy gradually. After two minutes, sodium hydroxide solution (1M, 1 ml) was quickly added to the reaction solution to adjust the pH value to 12. Become transparent, continue to react under vigorous stirring for 6 hours, and finally perform dialysis through deionized water, changing the water every 4 hours to remove excess Gd 3+ and Dy 3+ , to obtain BSA:Gd,Dy nanoparticles.

[0142] (b) Synthesis of BSA:Gd,Dy@PDA: adjust the pH value to 8.5 by Tris, add 45 mg of dopamine hydrochloride aqueous solution dissolved in 10 ml of deionized w...

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Abstract

The invention relates to the field of nanoscale biomedical materials, in particular to a nanometer material as well as a preparation method and application thereof. The nanometer material comprises BSA: RE1, an RE2 inner core, a PDA shell layer covering the surfaces of the BSA: RE1 and the RE2 inner core, and FA on the surface of PDA, where RE1 and RE2 are different. The nanometer material has good dispersibility, is easy to prepare, has excellent biocompatibility and safety, can accurately perform multimodal MRI / CT imaging on tumors, and has a good photothermal treatment effect on the tumors.

Description

technical field [0001] The invention relates to the field of nano biomedical materials, in particular to a nano material and its preparation method and application. Background technique [0002] Malignant tumor, also known as cancer, has been seriously endangering human health and life safety. It has the characteristics of unlimited proliferation, invasion and metastasis, and has surpassed cardiovascular disease to become the most serious disease causing human death. Tumor diagnosis plays an important role in tumor treatment. With the continuous development and updating of medical imaging methods and equipment, a variety of imaging diagnostic methods, including magnetic resonance imaging (MRI), X-ray computed tomography (CT) Imaging methods such as ultrasound imaging (UI), optical imaging (OI) and positron diffraction imaging (PET) are gradually emerging and improving, providing new ideas for tumor detection and location analysis. The multi-modal imaging methods (MRI / CT, ​​...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/04A61K49/14A61K49/12A61K49/10A61K49/18A61K41/00A61K9/51A61K47/22A61K47/34A61K47/42A61P35/00
CPCA61K9/5123A61K9/5146A61K9/5169A61K41/0052A61K49/0002A61K49/04A61K49/10A61K49/126A61K49/143A61K49/1833A61K49/1857A61K49/1869A61P35/00
Inventor 彭英华杨敏杨春刘莹孙胜楠张琦郭佳
Owner INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
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