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Method for preparing parecoxib freeze-dried powder injection

A technology for freeze-dried powder injection and parecoxib, which is applied in the field of preparation of parecoxib freeze-dried powder for injection, can solve problems such as manual operation and increase drying cost, achieve convenient inflow and outflow, and save drying energy consumption , Improve the cleaning effect

Inactive Publication Date: 2019-05-03
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of manual operation or increased drying cost in the cleaning and drying process in the prior art; provide a method for preparing parecoxib freeze-dried powder injection that solves the above problems

Method used

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  • Method for preparing parecoxib freeze-dried powder injection
  • Method for preparing parecoxib freeze-dried powder injection
  • Method for preparing parecoxib freeze-dried powder injection

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0042] A method for preparing parecoxib freeze-dried powder injection, comprising:

[0043] Step 1. Place the vials on the transmission line, and transport the vials to the cleaning tank through the transmission line for cleaning; the transmission line includes a transmission belt 1, a driving device 2 that drives the transmission belt 1 to rotate, and is arranged on the top of the transmission belt 1 and the transmission The restriction strip 4 of the bottleneck passage 3 of the vial is formed between the belts 1 . The conveyor belt 1 includes an in-plane moving section for transporting the vials according to the transport direction, and a rotating section for rotating the vials by 30 degrees, 45 degrees or 90 degrees perpendicular to the transport direction. Such as Figure 4 As shown in , the opening at the top of the in-plane moving section is arranged along the conveying direction. Such as Figure 5 As shown, the opening at the top of the rotating segment spirally surr...

Embodiment 2

[0055] The difference between this embodiment and Embodiment 1 is that the structure of the present invention is further optimized in this embodiment, and the specific settings are as follows:

[0056] The length of the rotating segment is greater than 5 cm. The vials transported in the in-plane moving section are arranged parallel to the horizontal plane. The flexible connecting strip 14 is a chain or a nylon rope. The driving device 2 includes a drive gear that drives the flexible connecting strip 14 to move by driving the push rod 12, and a drive motor that drives the drive gear to move; the drive gear includes an endless belt, and the meshing teeth arranged on the inner wall of the endless belt, The driving teeth arranged on the outer wall of the endless belt, and the rotating wheel arranged in the endless belt and meshed with the meshing teeth, the driving motor drives the rotating wheel to rotate and then drives the endless belt to rotate, and the rotation of the endles...

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Abstract

The invention discloses a method for preparing parecoxib freeze-dried powder injection. The problem in the prior art that in the cleaning and drying process, manual operation or increase of the dryingcost is needed is solved. The method for preparing parecoxib freeze-dried powder injection comprises the steps that firstly, phials are placed in a cleaning pool and cleaned; secondly, the phials cleaned are conveyed to a drying chamber through a conveying belt so that drying can be conducted and conveyed to a filling line after drying and cooling are conducted, the phials are filled with parecoxib freeze-dried powder through the filling line and covered with rubber plugs, and then the rubber plugs are sealed with aluminum foil covers; and thirdly, detection is conducted, wherein the phials are conveyed to a powder injection bottle labelling machine after being detected qualified and labelled, and the cleaning process in the first step is optimized. According to the method for preparing parecoxib freeze-dried powder injection, through optimization of the cleaning process, changes of different conveying directions can be achieved; in addition, steering of the phials can also be effectively achieved in the conveying process; and energy consumption of drying is saved.

Description

technical field [0001] The invention relates to a system for preparing powder injection, in particular to a method for preparing parecoxib freeze-dried powder injection. Background technique [0002] The conventional process for the preparation of powder injections is: bottle cleaning, bottle sterilization and drying, filling powder injections in the bottle, capping rubber stoppers, rolling and sealing aluminum caps, testing semi-finished products, and labeling. Existing systems suitable for the above process generally include: bottle washing machine, bottle drying equipment, powder injection filling machine (stoppering), powder injection bottle capping machine, light inspection machine, powder injection bottle labeling machine, etc. [0003] Bottle cleaning and sterilization drying in the prior art are carried out in different equipment, and after cleaning, it is necessary to manually place the cleaned vials in a vibrating water draining tank to drain the water, and then tr...

Claims

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Application Information

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IPC IPC(8): B65B55/24B65B43/52B65B1/04B65B57/04B65C3/08B65C9/26B67B1/00B67B5/00
Inventor 包莹杨明王静
Owner SICHUAN PHARMA
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