A differential equation model-based gene regulation and control network construction method

A gene regulatory network and differential equation model technology, applied in the fields of biotechnology and complex network science, can solve problems such as poor practicability, poor anti-noise ability, and high complexity, and achieve the effect of reducing the high complexity

Pending Publication Date: 2019-05-07
QINGDAO UNIV
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Defects in the existing differential equations to construct gene regulatory networks:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1

[0020] A method for constructing a gene regulatory network based on a differential equation model includes the following steps:

[0021] (1) Measure the cell cycle and gene expression under specific conditions at different time points, observe the changes in gene expression at each time point or during the cell cycle, and look for regulatory genes and target genes;

[0022] (2) Obtain the time series data of gene expression. The time series data is discretized into several expression levels;

[0023] (3) Set the time delay of gene regulation network;

[0024] (4) Use the algorithm of the differential equation model to determine the function according to the relationship between the function and its rate of change; make simple assumptions according to the modeling purpose and problem analysis, establish the differential equation according to the internal law or use the analogy method to derive the gene Regulatory network

[0025] (5) Graphical display of regulatory net...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a differential equation model-based gene regulation and control network construction method, and relates to the field of biotechnology and complex network science, and comprisesthe following steps: measuring gene expression in a cell cycle and under a specific state condition at different time points, observing change conditions of the gene expression at each time point orin the cell cycle, and finding a regulatory gene and a target gene; Acquiring time sequence data of gene expression, and discretizing the time sequence data into a plurality of expression levels by adopting a discretization method; utilizing An iterative algorithm of an ordinary differential equation, making corresponding assumptions according to the modeling purpose and problem analysis, mining the interaction relation between genes from large-scale gene expression data, and giving a topological structure model of the gene regulation and control network; Setting time delay of a gene regulation and control network; Graphically displaying the gene regulation and control network and carrying out structure analysis; And carrying out experimental verification on the gene regulation and controlnetwork of the target gene regulation and control relationship. Through data initialization processing, the defects of high complexity and large calculation amount are weakened.

Description

technical field [0001] The invention relates to the fields of biotechnology and complex network science, in particular to a method for constructing a gene regulation network based on a differential equation model. Background technique [0002] Genes support the basic structure and performance of life. It stores all the information about race, blood type, conception, growth, apoptosis and other processes of life. The interdependence of environment and heredity plays an important role in the reproduction of life, cell division and protein synthesis and other important physiological processes. [0003] Exploring and discovering the regulatory relationship and interaction mechanism between genes is a research hotspot and frontier topic in life sciences, and inferring gene regulatory networks from gene expression data is one of its research directions. [0004] Organisms express different parts of the genome through the regulation of gene level and transcription level at differ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G06F17/13G16B5/00
Inventor 王镇岭
Owner QINGDAO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap