Method for fetal urinary system malformation comprehensive evaluation

A comprehensive evaluation and technology of the urinary system, applied in urinary function evaluation, ultrasound/sonic/infrasonic Permian technology, ultrasound/sonic/infrasonic image/data processing, etc., can solve the problem of not being able to provide information about the cause of disease, kidney function, etc. question

Pending Publication Date: 2019-05-10
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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Problems solved by technology

[0003] The purpose of the present invention is to provide a new system for prenatal evaluation of fetal u...

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  • Method for fetal urinary system malformation comprehensive evaluation

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experiment example 1

[0030] Pregnant woman A inspection time: 23 weeks pregnant on May 24, 2018

[0031] 1. Ultrasound image acquisition and evaluation system: Use a color Doppler ultrasound instrument with a probe frequency of 3.5MHz to obtain the position of the kidneys, the size of the kidneys, the renal artery, the circumference of the kidneys / abdominal circumference, and the kidneys of the fetus in the pregnant woman's abdomen. Morphological characteristics such as cortical echo, cortical thickness, bilateral renal pelvis separation, bilateral ureter expansion, bladder size, shape, and amniotic fluid index. According to different contents, different image pictures are collected and stored in the ultrasound workstation. Ultrasound images show that the amniotic fluid index is 1.0 cm, and it is assessed as oligohydramnios, and the fetal urinary system may be deformed, so follow-up evaluation is performed.

[0032]2. After the step (1) outputs fetal urinary system abnormalities, interventional s...

experiment example 2

[0047] Pregnant woman B examination time: 23 weeks pregnant on July 19, 2018

[0048] 1. The method is the same as that of Experiment 1. Ultrasound image acquisition and evaluation system: Use a color Doppler ultrasound instrument with a probe frequency of 3.5MHz to obtain the position of the kidneys, the size of the kidneys, the renal artery, the circumference / abdominal circumference of the kidneys, and the cortex and medulla of the kidneys of the fetus in the pregnant woman's abdomen Morphological characteristics such as echo, cortical thickness, separation of bilateral renal pelvis, dilatation of bilateral ureter, bladder size, shape, and amniotic fluid index. According to different contents, different image pictures are collected and stored in the ultrasound workstation. Ultrasound images showed that the fetal left kidney was 1.4x1.0cm in size, the right kidney was 1.2x0.9cm in size, and the amniotic fluid index was 4.3cm. Ultrasound images show that if the kidneys are u...

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Abstract

The invention discloses a method for fetal urinary system malformation comprehensive evaluation. The method specifically comprises the following steps of (1) ultrasound image acquisition and evaluation; (2) interventional sampling; (3) whole genome sequencing and evaluation; (4) umbilical cord blood Cys C, beta 2-MG level determination; (5) comprehensive evaluation. The method for the fetal urinary system malformation comprehensive evaluation has the advantages that an ultrasonic imaging technology is utilized in combination with cord blood puncture DNA high-throughput sequencing, cord blood biochemical criterion CystC and beta 2-MG level determination, the three technologies are combined to comprehensively evaluating the severity degree of abnormal fetal kidney development of the structure, gene and function of the fetal kidney, people are prompted with adverse pregnancy outcome probability or postnatal surgical risk, thereby being conductive to providing complete clinical genetic counseling.

Description

technical field [0001] The present invention relates to a method for the assessment of urinary system abnormalities for detecting information on the medical condition of the fetus. Background technique [0002] Congenital anomalies of the urinary system CAKUT (congenital anomalies of the kidney andurinary tract,) include renal hypoplasia, horseshoe kidney, polycystic kidney, urinary tract obstruction, bladder exstrophy, vesicoureteral reflux, urinary duplication and other malformations. The incidence rate is about 3‰-6‰. Ultrasound examination during pregnancy found that CAKUT occurred in 1:500 fetuses, accounting for 20% to 30% of fetal malformations during pregnancy. Among them, 50% of children with CAKUT eventually developed chronic renal insufficiency. The prenatal assessment of fetal CAKUT has always been the focus and difficulty of fetal medicine. However, at present, domestic and foreign studies on CAKUT are mostly based on the evaluation of a single method of ultra...

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Application Information

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IPC IPC(8): A61B5/20A61B8/08A61B17/34
Inventor 黎冬梅朱宝生章锦曼镡颖陈红颖张阳佳
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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