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Solution preparation containing carbocisteine for atomizing inhalation and preparation method thereof

A carbocisteine ​​and atomized inhalation technology, which is applied in the field of carbocisteine ​​atomized inhalation solution preparation and its preparation, can solve the problems of large oral liquid intake, excessive liver and kidney metabolism, organ damage, etc. Safety, simple production process, quick effect

Inactive Publication Date: 2019-05-14
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The carbocisteine ​​is salted with sodium hydroxide solution, dissolved in water, then added with antioxidant, solution stabilizer combination and flavoring agent, and then prepared after stirring, constant volume, filtration, canning and sterilization, but oral administration If the dosage of the liquid is large, the metabolism of the liver and kidney is more, it is easy to cause organ damage, the amount of medicine reaching the target organ is less, and the onset of effect is slower

Method used

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  • Solution preparation containing carbocisteine for atomizing inhalation and preparation method thereof
  • Solution preparation containing carbocisteine for atomizing inhalation and preparation method thereof
  • Solution preparation containing carbocisteine for atomizing inhalation and preparation method thereof

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Effect test

Embodiment 1

[0031] Embodiment 1: single dose carbocisteine ​​nebulized inhalation solution preparation

[0032] prescription:

[0033] Carbocisteine ​​20mg

[0034] Edetate Disodium 0.1mg

[0035] Appropriate amount of sodium hydroxide, adjust the pH to 5

Embodiment 2

[0036] Embodiment 2: single dose carbocisteine ​​nebulized inhalation solution preparation

[0037] prescription:

[0038] Carbocisteine ​​40mg

[0039] Edetate Disodium 0.5mg

[0040] Appropriate amount of sodium hydroxide, adjust the pH to 6

Embodiment 3

[0041] Embodiment 3: Single dose carbocisteine ​​nebulized inhalation solution preparation

[0042] prescription:

[0043] Carbocisteine ​​50mg

[0044] Edetate Disodium 2mg

[0045] Appropriate amount of sodium hydroxide, adjust the pH to 6

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Abstract

The invention discloses a solution preparation containing carbocisteine for atomizing inhalation and a preparation method thereof. The solution preparation containing one dose of carbocisteine for atomizing inhalation is prepared from 20-120 mg of carbocisteine or salts and / or hydrates thereof (calculated as free carbocisteine), 0.1-5 mg of a metal complexing agent and a proper volume of a pH modifier and water for injection. The prepared solution preparation containing carbocisteine for atomizing inhalation has the advantages of high efficiency, low toxicity, good stability and high safety, and particularly reduces the medicinal toxicity in the liver and kidney of a patient greatly.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a carbocisteine ​​solution preparation for atomized inhalation and a preparation method thereof. Background technique [0002] Due to factors such as dense population, large number of smokers and environmental pollution, the morbidity and mortality of respiratory diseases have remained high in recent years. The cause of death (excluding tumors) rose from 10th in 1970 to 4th (chronic obstructive pulmonary disease) and 8th (pneumonia, influenza and upper respiratory tract infection) in 1991, while respiratory diseases in my country The incidence rate of the disease all accounts for the first of many diseases in any age group. This problem has attracted people's attention day by day, so the development of drugs for treating respiratory diseases (respiratory drugs for short) has also become an important research and development field of drug research. [0003] C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K47/18A61K47/02A61K31/198A61P11/00A61P11/10
CPCA61K9/0073A61K9/08A61K47/183A61K47/02A61K31/198A61P11/00A61P11/10A61K9/0078A61P11/08A61K9/12
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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