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Metal complex, preparation method and application of metal complex to heavy metal hazard control

A technology for metal complexes and heavy metals, which can be used in applications, pharmaceutical formulations, fertilizer mixtures, etc., and can solve problems such as low heavy metal removal effect and low toxicity

Inactive Publication Date: 2019-05-14
GUANGDONG ZHONGERJIAN BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of this, the present invention provides a metal complex, a preparation method and its application in the prevention and control of heavy metal hazards, which are used to solve the problems in the prior art that heavy metal scavengers cannot simultaneously take into account good heavy metal removal effects and low toxicity. technical flaw

Method used

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  • Metal complex, preparation method and application of metal complex to heavy metal hazard control
  • Metal complex, preparation method and application of metal complex to heavy metal hazard control
  • Metal complex, preparation method and application of metal complex to heavy metal hazard control

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The present embodiment is the specific embodiment of preparing D4, and the structural formula of D4 is:

[0041]

[0042] Its preparation method is specifically:

[0043] S1:

[0044] In a 500mL three-necked flask, add 100mL of purified water, continue to add 24 g of NaOH into the three-necked flask, stir to dissolve, and then cool to room temperature.

[0045] N 2 Under protection, after adding 89.5g of L-methionine, stirred for 20 minutes, continued to add 90g of D-glucose, and stirred evenly. continue at N 2 Under protection, react at 50-60°C for 4 hours.

[0046] After the reaction is completed, cool to below 20°C, and add 46.2g of NaBH in batches during stirring 4 ; After addition, the temperature was raised to 25°C and stirred overnight.

[0047] Cool the reaction solution below 20°C, slowly add concentrated HCl dropwise to pH = 2, and remove B(OH) by suction filtration 3 , the filtrate was concentrated under reduced pressure. Continue to add 500ml of...

Embodiment 2

[0056] This example is a specific example of determining the stability of D4 prepared in Example 1.

[0057] Test samples: D4 and D3.

[0058] Inspection conditions: high temperature (25°C±2°C, 40°C±2°C), light (4500lux±500lux), high humidity (25°C±2°C, 75%RH±5%RH), in 5 days, 10 days, 30 days sampling test.

[0059] Test items

[0060]

[0061] Test Results

[0062] 1. Stored at a high temperature of 40°C±2°C for 10 days, the properties of D4 and D3, the clarity and color of the solution, and the acidity have almost no change compared with the 0 day; however, the water content has increased significantly compared with the 0 day. The total impurity of D3 increased from 2.89% to 15.67%, and the impurity increased significantly, so it can be seen that D3 is unstable under high temperature conditions and needs to be preserved at low temperature. The total impurity of D4 increased from 2.43% to 4.28%, and the impurity increased significantly, but the increase was much lower...

Embodiment 3

[0067] This example is a specific example of measuring the cadmium-dispelling effect of D4 prepared in Example 1.

[0068] Modeling: Animals in the model group were given a mixed solution of Cd and ME (Cd: 3.0 μmol / kg body weight, ME: 12 μmol / kg body weight) at a dose of 5 mL / kg body weight through the ear vein, injected once a day for 5 consecutive days modeling. 35 days after the last injection, collect and detect rabbit blood, 6h metabolic urine, detect blood cadmium and urine cadmium levels, and screen 48 model animals, half male and half male. Modeling standard: Compared with the blank control group, the urine Cd content of the model animals increased, and there was a statistically significant difference (P<0.01). It suggested that the rabbit model of chronic cadmium poisoning was established successfully. 48 model animals were screened.

[0069] Drug treatment: Animals in each group were infused with corresponding drugs through ear veins, and the infusion rate was con...

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Abstract

The invention belongs to the field of heavy metal hazard control, particularly relates to a metal complex, a preparation method and an application of the metal complex to heavy metal hazard control, and provides a metal complex, a preparation method thereof and an application of the metal complex or a product prepared by the preparation method to the field of cadmium removal agent preparation, thefield of removal of food, agricultural product and vegetable heavy metal substance residues, soil and water heavy metal substance pollution control and removal of heavy metal substance residues in aquaculture industries. The product is easily dissolved in water, and heavy metal ions can replace metal ions in the metal complex, so that active-state heavy metal is inactive and cannot be absorbed. Besides, according to animal experiment determination, cadmium removing effects are good, toxicity is low, and the metal complex solves the technical problem that heavy metal removal agents cannot simultaneously achieve good heavy metal removing effects and low toxicity in the prior art.

Description

technical field [0001] The invention belongs to the field of heavy metal hazard prevention and control, and in particular relates to a metal complex, a preparation method and an application in heavy metal hazard prevention and control. Background technique [0002] Since there is no specific antidote for cadmium poisoning, the international community is helpless against cadmium poisoning and excessive levels. However, cadmium poisoning and exceeding standards often involve large-scale occupational poisoning groups and environmental pollution groups, and the human body lacks an effective mechanism to remove cadmium. [0003] According to the mechanism of chronic cadmium poisoning, the cadmium entering the human body will gradually combine with metallothionein (MT), and after being filtered out by the glomerulus, it will be reabsorbed in the renal tubules and accumulate in the renal tubular cells. When the accumulated cadmium ions exceed After the cells are overloaded, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C333/16C11D3/34C02F1/62C09K17/14A61K31/555A61P39/02
CPCA61K31/555A61P39/02C02F1/62C07C333/16C09K17/14C11D3/34
Inventor 唐小江卢肖宇胡伟钟志勇任雪峰
Owner GUANGDONG ZHONGERJIAN BIOTECH CO LTD
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