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Timosaponin BII temperature/ion-sensitive nasal in-situ gel and application thereof

A timosaponin and ion-sensitive technology, applied in the field of medicine, can solve the problems of prevention and treatment of Alzheimer's disease, etc., and achieve the effect of overcoming short local residence time and significant preventive and therapeutic effects

Inactive Publication Date: 2019-05-24
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its efficacy in the prevention and treatment of Alzheimer's disease has not been paid attention to

Method used

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  • Timosaponin BII temperature/ion-sensitive nasal in-situ gel and application thereof
  • Timosaponin BII temperature/ion-sensitive nasal in-situ gel and application thereof
  • Timosaponin BII temperature/ion-sensitive nasal in-situ gel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Step 1. Weigh 0.3 parts of deacetylated gellan gum in a beaker by weight, add an appropriate amount of deionized water, fully swell in a hot water bath at 70°C, and cool at 4°C;

[0043] Step 2: Take another 20 parts of poloxamer 407 and 0.1 part of sodium alginate in parts by weight, and slowly add them to the swollen deacetylated gellan gum in step 1 while stirring, stir evenly, and stand at 4°C for 5 hours , to get the gel matrix;

[0044] Step 3: Add 0.5 parts of chlorobutanol and 2.5 parts of hydroxypropyl-β-cyclodextrin to the gel matrix obtained in Step 2 while stirring to obtain a composite gel;

[0045] Step 4: Add 25 parts by weight of timosaponin BII to the composite gel obtained in step 3 under stirring to obtain the timosaponin BII temperature / ion-sensitive in-situ nasal gel.

Embodiment 2

[0047] Step 1. Weigh 0.1 part of deacetylated gellan gum in a beaker by weight, add an appropriate amount of deionized water, fully swell in a hot water bath at 80°C, and then cool at 4°C;

[0048] Step 2: Take another 16 parts of poloxamer 407 and 0.3 parts of sodium alginate in parts by weight, and slowly add them to the swollen deacetylated gellan gum in step 1 while stirring, stir evenly, and let stand at 4°C for 10 hours , to get the gel matrix;

[0049] Step 3: Add 0.5 parts of chlorobutanol and 2.5 parts of hydroxypropyl-β-cyclodextrin to the gel matrix obtained in Step 2 while stirring to obtain a composite gel;

[0050] Step 4: Add 5 parts by weight of timosaponin BII to the composite gel obtained in step 3 under stirring to obtain the timosaponin BII temperature / ion-sensitive in-situ nasal gel.

Embodiment 3

[0052] Step 1. Weigh 0.2 parts of deacetylated gellan gum in a beaker by weight, add an appropriate amount of deionized water, fully swell in a hot water bath at 70°C, and then cool at 4°C;

[0053]Step 2: Take another 18 parts of poloxamer 407 and 0.2 parts of sodium alginate in parts by weight, and slowly add them to the swollen deacetylated gellan gum in step 1 while stirring, stir evenly, and stand at 4°C for 5 hours , to get the gel matrix;

[0054] Step 3: Add 0.5 parts of chlorobutanol and 2.5 parts of hydroxypropyl-β-cyclodextrin to the gel matrix obtained in Step 2 while stirring to obtain a composite gel;

[0055] Step 4: Add 50 parts by weight of timosaponin BII to the composite gel obtained in step 3 under stirring to obtain the timosaponin BII temperature / ion-sensitive in-situ nasal gel.

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Abstract

The invention discloses timosaponin BII temperature / ion-sensitive nasal in-situ gel. The timosaponin BII temperature / ion-sensitive nasal in-situ gel comprises, by weight, 25 parts of timosaponin BII,18 parts of poloxamer 407, 0.3 part of deacetylated gellan gum, 0.1 part of sodium alginate, 0.5 part of chlorobutanol and 2.5 parts of hydroxypropyl-beta-cyclodextrin. The timosaponin BII temperature / ion-sensitive nasal in-situ gel has certain preventive and therapeutic effects on Alzheimer's disease.

Description

technical field [0001] The present invention relates to the field of medicine. More specifically, the present invention relates to timosaponin BII temperature / ion-sensitive nasal in-situ gel and its application. Background technique [0002] Alzheimer's disease (AD) refers to a chronic neurodegenerative disease with insidious onset and progressive development mainly in middle-aged and elderly people, mainly manifested in cognitive decline and behavioral disturbance. The pathogenesis of AD is not clear, but mainly includes three prominent pathological features, namely, neuritic plaques formed by β-amyloid deposition, neurofibrillary tangles manifested by hyperphosphorylation of Tau protein, and cholinergic tangles in the basal ganglia of the brain. Neuronal damage accompanied by massive loss of neurons]. Clinical trials have found that neuronal cell inflammatory damage can also accelerate the occurrence and development of AD. AD has a long course of disease and is difficul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7048A61K47/10A61K47/40A61P25/28
Inventor 杜丽娜金义光谌文元张丽花郝文艳
Owner ACADEMY OF MILITARY MEDICAL SCI
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